Autonomous University of the State of Hidalgo
Abasolo, Mexico
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Ortiz M.I.,Autonomous University of the State of Hidalgo
Canadian journal of physiology and pharmacology | Year: 2017

Experiments using nonsteroidal anti-inflammatory drugs (NSAIDs) alone have produced limited antinociceptive effects in animal models. For this reason, the number of studies involving the administration of NSAIDs along with an adjuvant drug harboring different mechanisms of action has increased enormously. Here, combinations of diclofenac and pyrilamine were used to determine their influence on nociception (formalin test), inflammation (paw inflammation produced by carrageenan), and gastric damage in rodents. Diclofenac, pyrilamine, or combinations of diclofenac and pyrilamine produced antinociceptive and anti-inflammatory effects in the rat. The systemic administration of diclofenac alone and in combination with pyrilamine produced significant gastric damage. Effective dose (ED) values were determined for each individual drug, and isobolograms were prepared. The theoretical ED values for the antinociceptive (systemic, 35.4 mg/kg; local, 343.4 μg/paw) and the anti-inflammatory (37.9 mg/kg) effects differed significantly from the experimental ED values (systemic antinociception, 18.1 mg/kg; local antinociception, 183.3 μg/paw; anti-inflammation, 10.6 mg/kg). Therefore, it was concluded that the interactions between diclofenac and pyrilamine are synergistic. The data suggest that the diclofenac-pyrilamine combinations can interact at the systemic and local peripheral levels, thereby offering a therapeutic alternative for the clinical management of inflammatory pain.

The present invention relates to a base powder for preparing functional beverages, soft drinks or an additive for food products, which is made with red raspberry from Rubus idaeus and with clinoptilolite zeolite contained in the ZAM (activated micronized zeolite). The powder is prepared with dehydrated fruit juice. The raspberry juice extract is obtained by slowly heating (without exceeding 70C) a pot containing the ground fruit or a receptacle with fruit, using the bain-marie method, without exceeding 70C. The juice is stabilized, dehydrated optionally mixed with sugar substitutes, sweeteners or fiber, and, lastly, homogenized. The object of the present invention is to provide a food-grade base powder of natural origin that is totally different from current presentations of red raspberry on the market. Likewise, the present invention seeks to utilize the therapeutic properties of said fruit as a coadjuvant in controlling active and passive tobacco consumption, nicotine detoxification and nicotine addiction, and also detoxification in the case of other toxic substances in tobacco smoke, as an antioxidant, antimutagenic, anticancer agent and immunostimulant. It is 100% rehydratable in water, easy to transport and has a shelf life in excess of one year.

Ortiz M.I.,Autonomous University of the State of Hidalgo
Life Sciences | Year: 2012

Aims: Recent evidence has shown that systemic administration of sulfonylureas and biguanides block the diclofenac-induced antinociception, but not the effect produced by indomethacin. However, there are no reports about the peripheral interaction between analgesics and the biguanides metformin and phenformin. Therefore, this work was undertaken to determine whether glibenclamide and glipizide and the biguanides metformin and phenformin have any effect on the peripheral antinociception induced by diclofenac and indomethacin. Main methods: Diclofenac and indomethacin were administered locally in the formalin-injured rat paw, and the antinociceptive effect was evaluated using the 1% formalin test. To determine whether peripheral antinociception induced by diclofenac or indomethacin was mediated by either the ATP-sensitive K + channels or biguanides-induced mechanisms, the effect of pretreatment with the appropriates vehicles or glibenclamide, glipizide, metformin and phenformin on the antinociceptive effect induced by local peripheral diclofenac and indomethacin was assessed. Key findings: Local peripheral injections of diclofenac (50-200 μg/paw) and indomethacin (200-800 μg/paw) produced a dose-dependent antinociception during the second phase of the test. Local pretreatment with glibenclamide, glipizide, metformin and phenformin blocked the diclofenac-induced antinociception. On the other hand, the pretreatment with glibenclamide and glipizide did not prevent the local antinociception produced by indomethacin. Nonetheless, metformin and phenformin reversed the local antinociception induced by indomethacin. Significance: Data suggest that diclofenac could activate the K + channels and biguanides-dependent mechanisms to produce its peripheral antinociceptive effects in the formalin test. Likewise, a biguanides-dependent mechanism could be activated by indomethacin consecutively to generate its peripheral antinociceptive effect. © 2011 Elsevier Inc.

Ortiz M.I.,Autonomous University of the State of Hidalgo
Pharmacology Biochemistry and Behavior | Year: 2011

There is evidence that administration of sulfonylureas, such as glibenclamide and tolbutamide, blocks diclofenac-induced antinociception, suggesting that diclofenac activates ATP-sensitive K + channels. However, there is no evidence for the interaction between diclofenac and other hypoglycemic drugs, such as the biguanides metformin or phenformin. Therefore, this work was undertaken to determine whether two sulfonylureas, glibenclamide and glipizide, as well as two biguanides, metformin and phenformin, have any effect on the systemic antinociception that is induced by diclofenac and indomethacin using the rat formalin test as an animal model. Systemic injections of diclofenac (10 to 30 mg/kg) and indomethacin (10 to 30 mg/kg) produced dose-dependent antinociception during the second phase of the test. Systemic pretreatment with glibenclamide (3 and 10 mg/kg), glipizide (3 and 10 mg/kg), metformin (100 and 180 mg/kg) or phenformin (100 and 180 mg/kg) blocked diclofenac-induced systemic antinociception in the second phase of the test (P < 0.05). In contrast, pretreatment with glibenclamide, glipizide, metformin or phenformin did not block indomethacin-induced systemic antinociception (P > 0.05). These data suggest that diclofenac, but not indomethacin, activated K + channels and metformin and phenformin-dependent mechanisms, which resulted in systemic antinociceptive effects in the rat formalin test. © 2011 Elsevier Inc. All rights reserved.

Moreno C.E.,Autonomous University of the State of Hidalgo | Rodriguez P.,Comision Nacional para el Conocimiento y Uso de la Biodiversidad
Oecologia | Year: 2011

After decades of misusing the term diversity in community ecology, over the last 5 years some papers have offered important advances toward developing a more rigorous mathematical background, which allows us to achieve more clarity in the terminology for the vast range of biological phenomena that have been placed under the umbrella of this term. Some points have been clearly stated in previous papers of this Views and Comments section, and new terms have even been proposed for specific cases, but other issues, such as the need for the prefix true have not been discussed. Our aim is to clarify some of the terms and concepts, the proper use of which appears still to remain unclear, and to provide biologists with a simplified version of the general framework resulting from recent contributions, with an emphasis on identifying points of consensus in the field. We also comment on the possibility of extending the basics of this general framework to other facets of the broad term biodiversity, such as functional or phylogenetic diversity. © 2011 Springer-Verlag.

Ortiz M.I.,Autonomous University of the State of Hidalgo
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2010

Objective: To evaluate the prevalence, impact and treatment of primary dysmenorrhea among Mexican university students. Study design: A multiple-choice questionnaire was administered to 1539 students in six university programs: medicine, nursing, nutrition, dentistry, pharmacy and psychology. Data on the presence, severity, symptoms, treatment and limitations caused by dysmenorrhea were obtained and analyzed. Results: The mean ± SD age of the women was 20.4 ± 2.0 years; the mean age of menarche was 12.3 ± 1.5 years. A total of 64% of the women experienced dysmenorrhea. Dysmenorrhea was more prevalent among nutrition and psychology students than among medicine, pharmacy and dentistry students (p < 0.05). Dysmenorrhea was mild in 36.1% of women, moderate in 43.8% and severe in 20.1%. Nursing students showed an intensity of pain that was significantly higher than that of medicine and dentistry students (p < 0.05). Sixty-five percent of the women with dysmenorrhea reported that it limited their daily activities, and 42.1% reported school absenteeism (SA) as a result. Of those who experienced dysmenorrhea, 25.9% consulted a physician, and 61.7% practiced self-medication (SM). The most common medications used were an over-the-counter (OTC) medication with paracetamol (an analgesic), pamabrom (a diuretic), and pyrilamine (a histamine antagonist), another OTC with metamizol (a non-steroidal anti-inflammatory drug [NSAID]) plus butylhioscine (an antispasmodic drug) and naproxen (a NSAID). Of those women using prescribed medications, 18.4% reported complete remission of their symptoms, while 78.1% reported little to moderate alleviation, and 3.6% reported no effect on their menstrual distress. Similarly, of the women who practiced SM, 23.4% reported complete relief, 75.5% reported little to moderate effectiveness, and 1.0% reported no efficacy. Conclusion: The prevalence of dysmenorrhea among Mexican university students is high, and the pain that these women suffer can be severe, disabling and result in short-term SA. The pain is often not completely relieved despite the use of medication. It is necessary to improve the therapeutic options for relief of pain caused by dysmenorrhea and to minimize the impact of dysmenorrhea on social, economic and school activities. © 2010 Elsevier Ireland Ltd.

Lopez-Ortega O.,Autonomous University of the State of Hidalgo
Expert Systems with Applications | Year: 2013

For creativity to be computed, it is paramount to understand the cognitive processes involved, which have been elucidated by either surveying creative people or discovering regions of the human brain that activate during creative endeavors. From this scattering, the author proposes a holistic framework to describe them and their interaction. Hence, creativity can be regarded as a meta process which coordinates autonomous cognitive processes such as planning or divergent thinking. To represent the interplay of cognitive processes around creativity, models are developed in the Agent Unified Modeling Language (AUML). Then, the execution of each process is delegated to autonomous agents and a global coordination protocol is devised. The implementation of the MAS is done on the JADE platform. Two modules of the resultant system are exemplified: opus planning and divergent exploration. The coordination protocol is also presented. The domain in which the software system is tested is the creation of musical pieces. © 2012 Elsevier Ltd. All rights reserved.

Silva M.L.S.,Autonomous University of the State of Hidalgo
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2015

Due to the increase in life expectancy in the last decades, as well as changes in lifestyle, cancer has become one of the most common diseases both in developed and developing countries. Early detection remains the most promising approach to improve long-term survival of cancer patients and this may be achieved by efficient screening of biomarkers in biological fluids. Great efforts have been made to identify specific alterations during oncogenesis. Changes at the cellular glycosylation profiles are among such alterations. The "glycosylation machinery" of cells is affected by malignant transformation due to the altered expression of glycogens, leading to changes in glycan biosynthesis and diversity. Alterations in the post-translational modifications of proteins that occur in cancer result in the expression of antigenically distinct glycoproteins. Therefore, these aberrant and cancer-specific glycoproteins and the autoantibodies that are produced in response to their presence constitute targets for cancer biomarkers' search. Different strategies have been implemented for the discovery of cancer glycobiomarkers and are herein reviewed, along with their potentialities and limitations. Practical issues related with serum analysis are also addressed, as well as the challenges that this area faces in the near future. © 2015 Elsevier B.V.

Moreno C.E.,Autonomous University of the State of Hidalgo | Rodriguez P.,CONABIO
Oecologia | Year: 2010

There is a genuine need for consensus on a clear terminology in the study of species diversity given that the nature of the components of diversity is the subject of an ongoing debate and may be the key to understanding changes in ecosystem processes. A recent and thought-provoking paper (Jurasinski et al. Oecologia 159:15-26, 2009) draws attention to the lack of precision with which the terms alpha, beta, and gamma diversity are used and proposes three new terms in their place. While this valuable effort may improve our understanding of the different facets of species diversity, it still leaves us far from achieving a consistent terminology. As such, the conceptual contribution of these authors is limited and does little to elucidate the facets of species diversity. It is, however, a good starting point for an in-depth review of the available concepts and methods. © 2010 Springer-Verlag.

Carbo-Ramirez P.,Autonomous University of the State of Hidalgo | Zuria I.,Autonomous University of the State of Hidalgo
Landscape and Urban Planning | Year: 2011

We explore bird communities in different types of small urban greenspaces (<2. ha) in order to understand which birds occupy these structures, and the habitat and landscape features that affect them. In particular we analyzed how greenspace characteristics (size and vegetation structure), those of the adjacent landscape (area covered by urban structures and vegetation), and human disturbance variables (traffic of pedestrians, vehicles and noise levels) affected bird species richness, abundance and community composition (during summer and winter) in the city of Pachuca, Mexico. We selected 19 small greenspaces (ranging from 0.1 to 2. ha), including public parks, gardens and road strip corridors. We registered 39 species of birds of which 15 were migratory. In general bird species richness was higher in parks and gardens, and lower in road strip corridors, where more noise and traffic was registered. Greenspace area was the most important variable that positively influenced bird species richness, for both the summer and the winter communities. Summer bird species richness was lower in places that had a greater percentage of area covered by buildings in the adjacent landscape. Generalist and opportunistic species were favored by urbanization. Insectivorous species in winter were more abundant in larger greenspaces that had taller trees and more tree and shrub species, and in sites with more vegetative cover in the adjacent landscape. We suggest some management and urban planning actions that would benefit birds within many Latin American cities, where small greenspaces are often the only available refuges for birds. © 2011 Elsevier B.V.

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