Konstantynowicz J.,Medical University of Bialystok |
Porowski T.,Medical University of Bialystok |
Zoch-Zwierz W.,Medical University of Bialystok |
Wasilewska J.,Medical University of Bialystok |
And 5 more authors.
European Journal of Paediatric Neurology | Year: 2012
Background: Although autistic spectrum disorders (ASD) are a strongly genetic condition certain metabolic disturbances may contribute to clinical features. Metabolism of oxalate in children with ASD has not yet been studied. Aim: The objective was to determine oxalate levels in plasma and urine in autistic children in relation to other urinary parameters. Method: In this cross-sectional study, plasma oxalate (using enzymatic method with oxalate oxidase) and spontaneous urinary calcium oxalate (CaOx) crystallization (based on the Bonn-Risk-Index, BRI) were determined in 36 children and adolescents with ASD (26 boys, 10 girls) aged 2-18 years and compared with 60 healthy non-autistic children matched by age, gender and anthropometric traits. Results: Children with ASD demonstrated 3-fold greater plasma oxalate levels [5.60 (5th-95th percentile: 3.47-7.51)] compared with reference [(1.84 (5th-95th percentile: 0.50-4.70) μmol/L (p < 0.05)] and 2.5-fold greater urinary oxalate concentrations (p < 0.05). No differences between the two groups were found in urinary pH, citraturia, calciuria or adjusted CaOx crystallization rates based on BRI. Despite significant hyperoxaluria no evidence of kidney stone disease or lithogenic risk was observed in these individuals. Conclusions: Hyperoxalemia and hyperoxaluria may be involved in the pathogenesis of ASD in children. Whether this is a result of impaired renal excretion or an extensive intestinal absorption, or both, or whether Ox may cross the blood brain barrier and disturb CNS function in the autistic children remains unclear. This appears to be the first report of plasma and urinary oxalate in childhood autism. © 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Kern J.K.,Genetic Consultants of Dallas |
Kern J.K.,Autism Treatment Center |
Kern J.K.,University of Texas Southwestern Medical Center |
Geier D.A.,Commonwealth Edison |
And 4 more authors.
Toxicological and Environmental Chemistry | Year: 2011
The purpose of this blinded study was to evaluate potential environmental toxicity in a cohort of neurotypical children (n = 28) living in a suburban area of north-central Texas in the United States (US) with a comparable age- and gender-matched cohort of neurotypical children (n = 8) living in a suburban area of southeastern France using urinary porphyrin testing: uroporphyrin (uP), heptacarboxyporphyrin (7cxP), hexacarboxyporphyrin (6cxP), pentacarboxypor-phyrin (5cxP), precoproporphyrin (prcP), and coproporphyrin (cP). Results showed significantly elevated 6cxP, prcP (an atypical, mercury-specific porphy-rin), and cP levels, and increasing trends in 5cxP levels, among neurotypical children in the USA compared to children in France. Data suggest that in US neurotypical children, there is a significantly increased body-burden of mercury (Hg) compared to the body-burden of Hg in the matched neurotypical children in France. The presence of lead contributing to the higher levels of cP also needs to be considered. Further, other factors including genetics can not be completely ruled out. © 2011 Taylor & Francis.
Autism Research Institute | Date: 2013-11-26
Printed publications in the nature of manuals on the topics of education, services, employment, and resources for adults with autism; printed curriculum for training others in the fields of general services provision, education, employment and resources for adults with autism. Educational and training services, namely, conducting live presentations, conferences, webinars, and classes for professionals, educators, families and individuals on the topics of education and employment of adults with autism, and issues facing entities that provide services to adults with autism, and distributing print and electronic course materials in connection therewith; Online electronic publishing of course curriculum, manuals, newsletters, and periodicals featuring information on the topics of education, employment, services, service provision, and resources for adults with autism.
Autism Research Institute | Entity website
Autism Research Institute | Entity website
ARI Earns 4-Stars - Charity Navigator Financial Information - 990s, Audits ARI Scientific Advisory Board Social Story: Today I Am Having a Blood Draw Continuing Medical Education Sleep Disorders in ASD Friends and Family: What to say ASD affects 1 in 68 children in U.S ...