Authority Hospital of Chengdu Military Region

Chengdu, China

Authority Hospital of Chengdu Military Region

Chengdu, China
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Li P.,PLA Fourth Military Medical University | Li P.,Authority Hospital of Chengdu Military Region | Xue Y.,PLA Fourth Military Medical University | Zhang W.,PLA Fourth Military Medical University | And 8 more authors.
Toxicology | Year: 2013

Sodium fluoride (NaF) is widely used for the treatment of dental caries and dentin hypersensitivity. However, its pro-apoptotic effect on odontoblasts may lead to harmful side-effects. The purpose of this study was to evaluate the pro-apoptotic effects of NaF in odontoblasts and elucidate the possible underlying molecular mechanisms. NaF generated cytotoxic effects in odontoblast-lineage cell (OLC) in a dose- and time-dependent manner. Exposure of cells to 4. mM NaF for 24. h induced caspase-3 activation, ultrastructural alterations, and resulted in the translocation of Bax to the mitochondria and the release of cytochrome c from the mitochondrial inter-membrane space into the cytosol, indicating that fluoride-mediated apoptosis is mitochondria-dependent. Fluoride treatment also increased phosphorylation of JNK and ERK, but not p38, and apoptosis induced by fluoride was notably or partly suppressed by treatment with JNK or ERK inhibitors, respectively.Taken together, these findings suggest that NaF induces apoptosis in OLC odontoblasts through a JNK-dependent mitochondrial pathway. © 2013 Elsevier Ireland Ltd.


Sun S.,Luzhou Medical College | Zhao F.,Authority Hospital of Chengdu Military Region | Sun Y.,Authority Hospital of Chengdu Military Region
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Primary stability of implants is the key factor to the success of implantation, and improving primary stability can raise the rate of successful implantation when bone quality is poor in implant region. OBJECTIVE: Through the establishment of the cancellous bone model to simulate the clinical dental implant surgery, to measure the primary stability of the implant so as to assess the bone extrusion operation effect as compared with the traditional hole prepared surgery. METHODS: Bone segments from the crest of scapular spine of fresh pigs were made into cuboid bone blocks (n=12) of 10 mm×10 mm×10 mm. After fixation, bone extrusion operation and traditional hole prepared surgery were performed to implant BEGO implants with the same specifications and the same type. Primary stability of implants was recorded, and t test was performed. RESULTS AND CONCLUSION: Compared with the traditional hole prepared surgery, a better primary stability for the implant was obtained following bone extrusion operation (P < 0.05), indicating that bone extrusion operation is better for primary stability of implants.

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