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Kavoussi P.K.,Austin Fertility & Reproductive Medicine Westlake IVF | Summers-Colquitt R.B.,Austin Fertility & Reproductive Medicine Westlake IVF | Odenwald K.C.,Austin Fertility & Reproductive Medicine Westlake IVF | Kressin M.,St Davids South Austin Medical Center | And 3 more authors.
Journal of Assisted Reproduction and Genetics | Year: 2016

Purpose: The objective of this study was to offer a new treatment approach for sperm retrieval simultaneously with tumor resection in azoospermic men with congenital adrenal hyperplasia (CAH), orchialgia, and bilateral testicular adrenal rest tumors (TARTs) who fail to respond to medical treatment. Methods: This is a retrospective chart review from a couple’s fertility center. Results: Between May 2013 and May 2015, two azoospermic men with CAH and bilateral TARTs, with orchialgia, and desire to conceive underwent bilateral TART resection in the same surgical setting as sperm retrieval after remaining azoospermic with normalization of gonadotropins with treatment with human chorionic gonadotropin (hCG). Both men had adequate sperm retrieved for in vitro fertilization/intracytoplasmic sperm retrieval (IVF/ICSI) at the time of bilateral TART resections. They had complete TART resections with resolution of orchialgia. The wife of one patient had a successful pregnancy with use of retrieved sperm resulting in a live birth, and the sperm from the other man is cryopreserved for future use. Conclusions: It is feasible to perform successful sperm retrieval simultaneously with TART resection in azoospermic men with CAH after medical treatments with persistent azoospermia, rather than subjecting these men to multiple invasive procedures. © 2016 The Author(s) Source


Kavoussi S.K.,Austin Fertility & Reproductive Medicine Westlake IVF | Odenwald K.C.,Austin Fertility & Reproductive Medicine Westlake IVF | Summers-Colquitt R.B.,Austin Fertility & Reproductive Medicine Westlake IVF | Kavoussi P.K.,Austin Fertility & Reproductive Medicine Westlake IVF | And 3 more authors.
Journal of Assisted Reproduction and Genetics | Year: 2015

Purpose: The purpose of the study was to report a case of live birth following donor oocyte in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in which the oocyte donor herself was conceived via IVF. To our knowledge, such a case has not been previously reported. Methods: Retrospective chart review; this case is reported after chart review of a successful outcome. Results: A 42 year-old woman, with diminished ovarian reserve, and her husband desired to conceive. She underwent a fresh IVF/ICSI cycle with her own oocytes, which unfortunately was not fruitful in terms of pregnancy or cryopreserved embryos. The couple was counseled regarding the option of donor oocytes, and they elected to proceed with a fresh cycle of donor oocyte IVF/ICSI. The couple selected an anonymous oocyte donor from a donor agency who was a first-time oocyte donor and, interestingly, was conceived via IVF herself. The fresh donor oocyte/IVF/ICSI cycle did not result in pregnancy; however, two supernumerary blastocysts were cryopreserved for future cycles. The recipient’s subsequent frozen-thawed embryo transfer (FET) resulted in a singleton gestation and live birth. Conclusions: An oocyte donor who was conceived via IVF had good ovarian response to stimulation, a good number of oocytes retrieved, and the formation and cryopreservation of blastocysts which, in a subsequent FET cycle, resulted in pregnancy and live birth for a recipient couple. To our knowledge, this is the first case reported of live birth with the use of donor oocytes from an oocyte donor who herself was conceived via IVF. © 2015, The Author(s). Source

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