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Rao V.J.,Aurobindo Pharma Ltd Research Center | Shankar R.,Jawaharlal Nehru Technological University | Mukkanti K.,Jawaharlal Nehru Technological University | Vekariya N.A.,Jawaharlal Nehru Technological University
Der Pharma Chemica | Year: 2013

Novel and improved synthesis of Famciclovir drug substance through N-(2-amino-4-chloro-6-[[4-hydroxy-3-(hydroxymethyl)butyl]amino]pyrimidin-5-yl)formamide from 4-amino-2-hydroxymethyl-1-butanol and N-(2-Amino-4, 6-dichloro-5-pyrimidinyl)formamide. Further this synthetic method involves the 2-acetoxymethyl-4-azido-1-butyl acetate and 4-azido-2-hydroxymethyl-1-butanol as novel intermediates in the preparation of 4-amino-2-hydroxymethyl-1-butanol. Source

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