Arad, Romania

Aurel Vlaicu University

www.uav.ro
Arad, Romania

Aurel Vlaicu University of Arad is a state university founded in 1972/1990 in Arad, Romania. Wikipedia.


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Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-4.0-1 | Award Amount: 6.64M | Year: 2009

NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: Design , development and production of nanobiodevices (FBN) targeting directly effector cells Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages Design of models that will enable to minimize animal experimentation. Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.


Duma V.-F.,Aurel Vlaicu University
Latin American Journal of Solids and Structures | Year: 2013

Optical choppers with rotating wheels are some of the most used macroscopic optomechatronic devices for the controlled modulation, attenuation or obscuration of light in a wide area of applications. We discuss and compare the modulation functions produced by two types of chopper wheels: the classical device, with windows with linear edges, and the eclipse chopper (with windows with circular edges) that, to the best of our knowledge, we have introduced. This discussion is based on the analysis and the design we have previously developed for these various devices, for top-hat (constant over the entire section) light beam distributions. While the comparison of the different shapes of transmitted signals allows for the proper choice of the most appropriate device and parameters to obtain the modulation function that is fit for a certain application, the present work also presents the mechanical setup we have designed and manufactured for testing choppers with rotating wheels. A series of prototype wheels with different, optimized profiles were obtained for the purpose. The simulation and the electro-erosion programs for the wire electro-erosion of aluminum plates to manufacture the wheels are presented. An advantageous double wheel solution has been developed to obtain wheels with windows of different shapes and sizes, and the testing of this final assembly concludes the study.


Duma V.-F.,Aurel Vlaicu University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2013

The paper presents some of our advances in the study and development of optical choppers. The modulation functions we have studied for classical choppers are pointed out - for top-hat (constant intensity) light beam distributions. The eclipse choppers that, to the best of our knowledge we have introduced are also presented. We thus point out the differences between the profiles of light (laser) impulses produced by the classical devices (with rotating wheels with windows with linear edges) and the novel eclipse choppers - under patent (with windows with circular edges that produce for the circular-shaped section of the laser beam in the plane of the wheel a planetary eclipse-like effect - from which the name we have proposed for this type of device). The most convenient (from the technological and from the cost point of view) solution, with wheels with circular holes is also obtained. The advantages and the drawbacks of the various devices are discussed. Both a theoretical and an experimental approach are considered. The latter is done on a chopper module we have constructed, with prototype chopper wheels we have designed and manufactured. Throughout the study, top-hat laser beams are considered, as they are most used in laser manufacturing applications. The perspective of conducting the study on other light beams distributions (e.g., Gaussian) is also pointed out. © 2013 Copyright SPIE.


Duma V.-F.,Aurel Vlaicu University
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2014

We review some of the most important scanning systems that are competitive in high-end biomedical imaging applications such as Optical Coherence Tomography (OCT), but also Confocal Microscopy (CM) or multiphoton microscopy. Both 1-D (uni-dimensional) and 2-D (bi-dimensional) scanning systems are considered. The paper discusses different scanners, including polygon mirror, galvanometer-based and Risley prisms. Their configurations and characteristics, as well some of our contributions in the domain are presented. The tendency of applying them into special designs such as handheld scanning probes and endoscopes - the latter with MEMS (Micro-Electro-Mechanical Systems) and micro-systems is pointed out. A discussion on further advancements of scanning technology in biomedical applications in general and in OCT in particular concludes the study. © 2014 Copyright SPIE.


Ndban S.,Aurel Vlaicu University
Fuzzy Sets and Systems | Year: 2016

In the present paper we firstly introduce the notion of fuzzy pseudo-norm, then we extend, improve and complete the results obtained by T. Bag and S.K. Samanta for fuzzy norms, in the fuzzy pseudo-norms context. Lastly, we introduce and discuss the notions of fuzzy F-norm and fuzzy F-space. By means of several auxiliary results, we obtain a characterization of metrizable topological linear spaces in terms of fuzzy F-norm. © 2014 Elsevier B.V.


Nadaban S.,Aurel Vlaicu University
International Journal of Computers, Communications and Control | Year: 2015

In this paper we continue the study of fuzzy continuous mappings in fuzzy normed linear spaces initiated by T. Bag and S.K. Samanta, as well as by I. Sadeqi and F.S. Kia, in a more general settings. Firstly, we introduce the notion of uniformly fuzzy continuous mapping and we establish the uniform continuity theorem in fuzzy settings. Furthermore, the concept of fuzzy Lipschitzian mapping is introduced and a fuzzy version for Banach's contraction principle is obtained. Finally, a special attention is given to various characterizations of fuzzy continuous linear operators. Based on our results, classical principles of functional analysis (such as the uniform boundedness principle, the open mapping theorem and the closed graph theorem) can be extended in a more general fuzzy context. © 2006-2015 by CCC Publications.


Duma V.-F.,Aurel Vlaicu University | Podoleanu A.G.,University of Kent
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2013

We review briefly the different applications of polygonal mirror (PM) scanning heads in biomedical imaging, with a focus on Optical Coherence Tomography (OCT). This overview of biomedical optical systems that employ PMs include: (i) TD (Time Domain) OCT setups, where PM may be utilized for generating the modulation function of the system without separate translation stages; (ii) FD (Fourier Domain) OCT delay line systems, with PM arrays; (iii) broadband laser sources scanned in frequency, for SS (Swept Source) OCT, with the PM placed in various optical configurations; (iv) OCM (Optical Coherence Microscopy) system with double PMs; (v) 2D PM plus galvanometer-based scanner (GS) for fast lateral scanning (not only in OCT, but also in confocal microscopy). We discuss SSs, for which the various PMbased setups used are compared, in their evolution - from on-axis to off-axis polygons - and in the race to obtain higher scan speeds to achieve real-time in vivomedical imaging. The parameters, advantages and drawbacks of these different configurations are pointed out. A necessary comparison is also made with the much faster Fabry-Perot (FP) based SSs. Our approach on PM-based broadband laser sources scanned in frequency, based on a simple off-axis polygon configuration, is also presented. Some of its characteristic mathematical functions are inferred and evaluated. © 2013 Copyright SPIE.


Palcu A.,Aurel Vlaicu University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We prove in this paper that the electroweak SU(4) L - U(1) X gauge models with spontaneous symmetry breaking can offer a natural framework for generating neutrino masses by simply exploiting the tree level realization of dimension-five effective operators. The novelty of our approach resides in the fact that the scalar sector needs not to be enlarged, since these operators are constructed as direct products among scalar multiplets already existing in the model. There is a unique generic matrix for Yukawa couplings in the neutrino sector. The charged leptons are already in their diagonal basis. This framework can lead to a suitable fit of the established phenomenology for the left-handed neutrinos, while the right-handed neutrino masses come out in the sub-keV region, independently of the cutoff Λ. The latter introduces in the theory an intermediate scale (however, more close to GUT than to SM) at about 1012GeV which is a crucial ingredient for the left-handed neutrino phenomenology. © 2012 American Physical Society.


Duma V.-F.,Aurel Vlaicu University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2013

We present a brief overview of our contributions in the field of laser scanning technologies, applied for a variety of applications, from industrial, dimensional measurements to high-end biomedical imaging, such as Optical Coherence Tomography (OCT). Polygon Mirror (PM) scanners are presented, as applied from optical micrometers to laser sources scanned in frequency for Swept Sources (SSs) OCT. Galvanometer-based scanners (GSs) are approached to determine the optimal scanning function in order to obtain the highest possible duty cycle. We demonstrated that this optimal scanning function is linear plus parabolic, and not linear plus sinusoidal, as it has been previously considered in the literature. Risley prisms (rotational double wedges) scanners are pointed out, with our exact approach to determine and simulate their scan patterns in order to optimize their use in several types of applications, including OCT. A discussion on the perspectives of scanning in biomedical imaging, with a focus on OCT concludes the study. © 2013 SPIE.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2010-IRSES | Award Amount: 319.20K | Year: 2011

Recent advances of biopolymer mass spectrometry - first highlighted by the Nobel Prize-awarded soft ionization methods - have opened new applications in life sciences, such as the identification of proteins from complex biological material (proteomics). A number of high performance mass spectrometry technologies and hyphenated separation methods have become amenable; however, their efficient exploration and integration in interdisciplinary biochemical and biomedical applications is still in the initial phase. In this project an effective exchange scheme of staff will be established between European laboratories of different application areas, and leading American Centers of high performance biopolymer mass spectrometry. Joint research projects through exchange of coworkers will focus on the determination of protein structures and pathophysiological structure modifications; the identification of the assembly and topology of large protein complexes; development and application of disease-related quantitative proteome analysis; characterization of protein conformations and misfolding/aggregating proteins; applications to elucidate protein-biopolymer interactions and molecular recognition structures using new tools of bioaffinity-mass spectrometry. The principal goals of this project are (i), to establish new technologies of mass spectrometry in important life science applications such as the identification of biomarkers for disease diagnostics; and (ii), to provide a basis, through exchange of coworkers, for the integration of mass spectrometry tools with biochemical and biomedical technologies. This project will contribute to (i), integrate interdisciplinary applications of biopolymer mass spectrometry in life sciences; (ii), enhance exchange and collaboration between European and North-American academic laboratories; (ii) the graduate and postgraduate education of young researchers in mass spectrometry in life sciences.

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