Entity

Time filter

Source Type

Östermalm, Sweden

Mahon E.,French National Center for Scientific Research | Aastrup T.,Attana AB | Barboiu M.,French National Center for Scientific Research
Topics in Current Chemistry | Year: 2012

Molecular recognition in biological systems occurs mainly at interfacial environments such as membrane surfaces, enzyme active sites, or the interior of the DNA double helix. At the cell membrane surface, carbohydrate-protein recognition principles apply to a range of specific non-covalent interactions including immune response, cell proliferation, adhesion and death, cell-cell interaction and communication. Protein-protein recognition meanwhile accounts for signalling processes and ion channel structure. In this chapter we aim to describe such constitutional dynamic interfaces for biosensing and membrane transport applications. Constitutionally adaptive interfaces may mimic the recognition capabilities intrinsic to natural recognition processes. We present some recent examples of 2D and 3D constructed sensors and membranes of this type and describe their sensing and transport capabilities. © 2011 Springer-Verlag Berlin Heidelberg. Source


Xu H.,Northwest University, China | Lu Y.,Northwest University, China | Zhou Y.,Huazhong University of Science and Technology | Ren B.,Huazhong University of Science and Technology | And 4 more authors.
Advanced Synthesis and Catalysis | Year: 2014

An efficient one-pot method for the selective benzylation of diols and polyols using 0.1 equiv. of organotin reagents and tetrabutylammonium bromide as catalyst has been developed. The diols and polyols containing a cis-vicinal diol were regioselectively benzylated in 70-94% isolated yields. A catalytic reaction mechanism was also proposed. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Mahon E.,French National Center for Scientific Research | Aastrup T.,Attana AB | Barboiu M.,French National Center for Scientific Research
Chemical Communications | Year: 2010

Multivalent recognition of lectin layers by glyconanoparticle sugar-clusters has been used to study the carbohydrate-protein interactions in a QCM sensing setup. © The Royal Society of Chemistry 2010. Source


Mahon E.,French National Center for Scientific Research | Aastrup T.,Attana AB | Barboiu M.,French National Center for Scientific Research
Chemical Communications | Year: 2010

We describe multivalent biorecognition of adsorbed lectin layers by biomimetic sensing nanoplatforms based on dynamic glycovesicles in a continuous flow QCM setup. © The Royal Society of Chemistry. Source


Suriyanarayanan S.,Linnaeus University | Lee H.-H.,Linkoping University | Liedberg B.,Linkoping University | Aastrup T.,Attana AB | And 2 more authors.
Journal of Colloid and Interface Science | Year: 2013

A novel hyperbranched polyethyleneimine (PEI) modified gold surface has been designed, fabricated, and investigated with respect to its ability to resist non-specific adsorption of proteins. The facile synthesis strategy, based on self-assembly, involves immobilization of polyethyleneimine to gold surfaces modified with 11-mercaptoundecanoic acid (MuDA) monolayers using traditional carbodiimide chemistry. The hyperbranched polymer brushes were characterized by X-ray photoelectron spectroscopy (XPS). Reflection absorption infrared spectroscopy (RAIRS) and ellipsometry measurements showed the thickness of the PEI brushes increases with adsorption solution ionic strength. Polymer brush surface concentrations can be improved from 2560 to 3880chains/μm2 by changing the ionic strength of the adsorption solution (PBS) by varying NaCl concentration from 0 to 650mM. Protein adsorption (pH 7.4) was evaluated under flow injection analysis (FIA) conditions using a quartz crystal microbalance (QCM). The PEI brushes suppress protein adsorption, for example, cytochrome C, bovine serum albumin (BSA), and ribonuclease A, to less than 0.08μg/cm2 and the protein resistance increases with increasing ionic strength of the carrier solution, performance comparable to that achieved with comparable PEG-coated surfaces. The PEI brushes were exceptionally stable, with adsorption characteristics maintained after 6months storage in aqueous conditions (pH 7.4, 25°C, PBS). The potential of hyperbranched PEI structures as protein-resistant surfaces is discussed. © 2013 Elsevier Inc. Source

Discover hidden collaborations