Pittsburgh, PA, United States
Pittsburgh, PA, United States

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Patent
ATRP Solutions | Date: 2016-06-06

Oil soluble rheology modifying star macromolecules having a core and five or more polymeric arms, and compositions comprising the same. The polymeric arms on a star are covalently attached to the core of the star; each polymeric arm comprises one or more (co)polymer segments; and at least one polymeric arm and/or at least one polymeric segment exhibits a different solubility from at least one other polymeric arm or one other polymeric segment, respectively, in a reference liquid of interest. The oil soluble rheology modifying star macromolecules and compositions comprising the same for use in oil based systems.


Patent
ATRP Solutions | Date: 2016-06-22

Oil soluble rheology modifying star macromolecules having a core and five or more polymeric arms, and compositions comprising the same. The polymeric arms on a star are covalently attached to the core of the star; each polymeric arm comprises one or more (co)polymer segments; and each polymeric arm comprises a monomeric unit of a methyl methacrylate. The oil soluble rheology modifying star macromolecules and compositions comprising the same for use in oil based systems.


Patent
ATRP Solutions | Date: 2014-02-07

A procedure for improved temperature control in controlled radical polymerization processes is disclosed. The procedure is directed at controlling the concentration of the persistent radical in ATRP and NMP polymerizations procedures and the concentration of radicals in a RAFT polymerization process by feeding a reducing agent or radical precursor continuously or intermittently to the reaction medium through one of more ports.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 150.00K | Year: 2013

This Small Business Innovation Research Phase I project is directed towards the development of a non-ionic thickening agent for personal care products, which does not contain poly(ethylene glycol) (PEG). Reports have stated that commercially available PEG contains small levels of undesirable side products. Therefore, there is a strong need to create an efficient, PEG-free thickening agent. The proposed structure of the thickening agent is an amphiphilic copolymer, synthesized using a powerful polymerization technique known as atom transfer radical polymerization (ATRP). A systematic library of copolymers will be synthesized during this project, with variations in the architecture of the molecule, the type of hydrophilic and hydrophobic groups used, and the molecular weight. The thickening properties of each molecule will be determined in an aqueous solution, such as a shampoo base. It is expected that the best performing copolymers will efficiently thicken cosmetic formulations at concentrations of less than 1% by weight. The information obtained from the synthesized polymeric library will determine which copolymer should be optimized for scale-up and commercialization.

The broader impact/commercial potential of this project is the need to replace PEG-based personal care additives, driven by reports that these materials contain toxic side products left after the manufacturing process, such as 1,4-dioxane, among others. The United States Food and Drug Administration recognizes PEG as a source of potential contaminants, and has monitored levels of 1,4-dioxane in personal care products since the late 1970s. Although current products on the market have minimal amounts of 1,4-dioxane, heightened consumer awareness is causing several companies to consider PEG-free alternatives, especially in more sensitive applications. Besides personal care and cosmetic products, PEG is also used in all polymeric drug delivery systems that are on the market. For this type of application, even small amounts of toxic compounds are unacceptable. The technology used in this proposed research to develop a PEG replacement has great potential to also be used in the development of novel drug delivery systems. Therefore, the product generated from this research project is expected to attract considerable attention from several areas of industry.


Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 750.00K | Year: 2014

The broader impact/commercial potential of this Small Business Innovation Research Phase II project is significant. The purpose of this project is to create new ingredients which reduce the toxicity profile of personal care and cosmetics products. This project will achieve this by inventing and commercializing a new class of poly(ethylene glycol) PEG-free and 1,4 dioxane-free ingredients. The current, PEG- containing ingredients are highly sophisticated in their structure and function, however, PEG-base ingredients have been found to contain 1,4 dioxane residuals which are known to have a poor toxicity profile. In order to achieve a next generation PEG-free ingredient with improved performance, we will employ a new technique called atom transfer radical polymerization (ATRP). ATRP has proven to be a powerful method to produce polymers with improved structure, purity and function for a broad range of applications including cosmetics, biomaterials, home care, paints and adhesives. This technique, however, has also proven to be difficult to scale to commercial volumes. The result of this project will not only be improved thickeners for personal care and cosmetics products, but, it will also be a commercial process so that ATRP can be used to produce polymers with improved performance for broad market segments. This Small Business Innovation Research Phase II project includes work relevant to both the advancement of atom transfer radical polymerization (ATRP) technology (especially as it related to chemical engineering and scaling) and an advancement of the understanding of polymer structure and function for the field of rheology modifiers. Today, ATRP technology is commonly implemented using methods acceptable in the laboratory setting. In this project, we will be adapting ATRP to a scalable, efficient, cost effective industrial process. Multiple-step synthesis will be simplified to a one-pot process. The post-synthesis procedures will be optimized to save costs, eliminate toxic residuals and reduce the amount of waste generated. The result of this work will be carry with them significant intellectual merits applicable to scaling any polymer produced by ATRP technology. This project will also deepen understanding of structure to function relationships for this new class of rheology modifiers. This knowledge will not only enable commercialization of new and improved ingredients for personal care and cosmetics, but, it will also enable new high performance polymers for many new products.


A procedure for improved temperature control in controlled radical polymerization processes is disclosed. The procedure is directed at controlling the concentration of the persistent radical in ATRP and NMP polymerizations procedures and the concentration of radicals in a RAFT polymerization process by feeding a reducing agent or radical precursor continuously or intermittently to the reaction medium through one of more ports.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: SMALL BUSINESS PHASE II | Award Amount: 760.00K | Year: 2014

The broader impact/commercial potential of this Small Business Innovation Research Phase II project is significant. The purpose of this project is to create new ingredients which reduce the toxicity profile of personal care and cosmetics products. This project will achieve this by inventing and commercializing a new class of poly(ethylene glycol) PEG-free and 1,4 dioxane-free ingredients. The current, PEG- containing ingredients are highly sophisticated in their structure and function, however, PEG-base ingredients have been found to contain 1,4 dioxane residuals which are known to have a poor toxicity profile. In order to achieve a next generation PEG-free ingredient with improved performance, we will employ a new technique called atom transfer radical polymerization (ATRP). ATRP has proven to be a powerful method to produce polymers with improved structure, purity and function for a broad range of applications including cosmetics, biomaterials, home care, paints and adhesives. This technique, however, has also proven to be difficult to scale to commercial volumes. The result of this project will not only be improved thickeners for personal care and cosmetics products, but, it will also be a commercial process so that ATRP can be used to produce polymers with improved performance for broad market segments.

This Small Business Innovation Research Phase II project includes work relevant to both the advancement of atom transfer radical polymerization (ATRP) technology (especially as it related to chemical engineering and scaling) and an advancement of the understanding of polymer structure and function for the field of rheology modifiers. Today, ATRP technology is commonly implemented using methods acceptable in the laboratory setting. In this project, we will be adapting ATRP to a scalable, efficient, cost effective industrial process. Multiple-step synthesis will be simplified to a one-pot process. The post-synthesis procedures will be optimized to save costs, eliminate toxic residuals and reduce the amount of waste generated. The result of this work will be carry with them significant intellectual merits applicable to scaling any polymer produced by ATRP technology. This project will also deepen understanding of structure to function relationships for this new class of rheology modifiers. This knowledge will not only enable commercialization of new and improved ingredients for personal care and cosmetics, but, it will also enable new high performance polymers for many new products.


Patent
ATRP Solutions | Date: 2014-08-14

A procedure for improved temperature control in controlled radical polymerization processes is disclosed. The procedure is directed at controlling the concentration of the persistent radical in ATRP and NMP polymerizations procedures and the concentration of radicals in a RAFT polymerization process by feeding a reducing agent or radical precursor continuously or intermittently to the reaction medium through one of more ports.


Patent
ATRP Solutions | Date: 2014-02-03

The present invention relates to multi-arm salt-tolerant star macromolecules, and methods of preparing and using the same. In one aspect of the invention, a salt-tolerant star macromolecule is capable of providing salt-tolerance to an aqueous composition.


A procedure for improved temperature control in controlled radical polymerization processes is disclosed. The procedure is directed at controlling the concentration of the persistent radical in ATRP and NMP polymerizations procedures and the concentration of radicals in a RAFT polymerization process by feeding a reducing agent or radical precursor continuously or intermittently to the reaction medium through one of more ports.

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