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Elliott M.H.,Atrium Research and Consulting
Scientific Computing | Year: 2011

Modern mobile devices have converged most of the smartphone functionality into a thin, mobile, yet simple to use computing platform. Users want a simplified experience that eliminates multiple interfaces and also consolidates platforms to reduce costs. These consumer desires are pushing vendor solutions like laboratory information management systems (LIMS) and electronic laboratory notebooks (ELN) outside of their traditional boundaries. Convergence is changing the market landscape for vendors. The rush to offer a single ELN platform spanning multiple application needs is driving an unprecedented level of mergers and acquisitions (M&A). In the era of the iPad-savvy populous, a challenge for developers is to support the desires of convergence in a user experience that is inviting and pleasurable. The need for new capabilities should be supported in a modular, service-based architecture to avoid the mistakes of the unwieldy monolithic system. The future of ELN will require innovative and disruptive thinking to provide users with an engaging user experience far above traditional approaches.


Elliott M.H.,Atrium Research and Consulting
Scientific Computing | Year: 2012

Michael H. Elliott shares his views on how externalization workflow is impacting traditional data management architectures in the pharmaceutical industry. Pharmaceutical companies have adopted a more aggressive approach toward externalizing drug discovery. Some of them report a target of between 30 to 50 percent of discovery work to be through partner alliances. A full range of arrangements are being pursued, ranging from university collaborations for target identification, to medicinal chemistry with partners in China, to in vitro screening shops in India. A survey conducted by Atrium Research has revealed that only a few companies have a comprehensive externalization data management strategy, despite many of them being engaged in partnerships and collaborations. Eighty percent of these companies are exchanging biology data with partners via e-mail and Excel spreadsheets, despite having robust internal bioassay data management systems, electronic laboratory notebooks (ELN), and laboratory information management systems (LIMS).


Elliott M.H.,Atrium Research and Consulting
Scientific Computing | Year: 2013

An area of accelerating market growth for electronic laboratory notebook (ELN) technology is in analytical sciences, specifically late state biopharmaceutical development and quality. The large number of ELN users in the un-regulated world of research has inspired organizations to gain similar improvements in efficiency downstream on the R&D continuum. Quality by design (QbD) initiatives combined with efforts to accelerate time-to-market, are motivating clients to evaluate solutions to expedite technology and method transfer. Progressing companies are turning to ELN as one of the tools to help build a bridge over the traditional development and quality gap. The work for developing a new method is freeflowing and lends itself well to many of the research ELN products on the market. A basic template in the ELN is used for documentation of objectives, materials, buffers, standards, instrument run conditions, and entry of a selective set of results like a representative chromatogram.


Elliott M.H.,Atrium Research and Consulting
Scientific Computing | Year: 2013

Data management and workflow support through a modern ELN (electronic laboratory notebook) can help to alleviate the stress of biologics research and development (R&D). The capabilities an ELN must have are unlike those needed for chemistry or in vivo biology. Merck and Company was one of the companies that evolved the use of their ELN beyond their original paperless lab objective. Working with Merck, PE incorporated their BioAssay screening and RDLIMS sample tracktioning modules into their E-Notebook ELN and adapted them for structured biologics data capture, management and analysis. Any potential users to never underestimate the ELN's impact on culture and to make sure that management are fully behind the project. The functionality and the advantages is having a single database for housing all BTxPS non-GMP and GMP data to facilitate reporting of data across the development life cycle. Lonza is deploying IDBS' E-Workbook/BioBook ELN to over 300 users from bioprocess to analytical, supporting both non-GMP and GMP workflows on the same instance.


Elliott M.H.,Atrium Research and Consulting
Scientific Computing | Year: 2010

Cloud computing and software-as-a-service (SaaS) are gaining popularity and find increasing use in several applications. A software supplier provides access to their software over the Internet for a monthly fee with data management services and support included in a cloud environment. Applications such as customer relationship management (CRM) and pharmaceutical clinical trials electronic data capture (EDC) have been successfully hosted by these external third parties for over a long period of time motivated by lower administration costs, absence of capital outlay, lack of available IT resources, and geographically dispersed user bases. Several electronic laboratory notebook (ELN) suppliers have introduced hosted solutions as an option to the traditional perpetual licenses installed at customer locations. A hosted private cloud is essentially a buzz term for a traditional hosting solution where a party maintains the application for an end-user client.

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