Entity

Time filter

Source Type

Beijing, China

Deng X.-S.,Atom Hi Technology Co. | Zhao G.-Z.,Atom Hi Technology Co. | Zhang B.-Q.,Atom Hi Technology Co. | Liu Y.-P.,Atom Hi Technology Co. | And 10 more authors.
Yuanzineng Kexue Jishu/Atomic Energy Science and Technology | Year: 2016

Using the CIAE-30 cyclotron, a 124Xe gas target system for the production of high purity 123I was established. This system includes 124Xe gas target station and the transmission line of the 30 MeV proton beam, the He cooling system for the sealed windows of target and beam-line, the water cooling system, the vacuum system for target chamber, the system for 124Xe processing and the system for the chemical processing of 123I. It also includes 124Xe retention system, LN2 transfer system, He gas transfer system and the system for 124Xe supplement, as well as the system for beam current adjusting, measuring and controlling, and the system for radiation protection and detection. The performance tests for the system, and the setting up of the conditions for the experiments prove that this system can offer 111-148 GBq (3-4 Ci) of 123I in one batch with a production rate greater than 296 MBq/(μA·h) (8 mCi/(μA·h)). The radionuclide purity of 123I is better than 99.8%, and the radiochemical purity is better than 95%, which fits the needs of the production in scale. © 2016, Editorial Board of Atomic Energy Science and Technology. All right reserved. Source


Qing J.,China Institute of Atomic Energy | Qing J.,Atom Hi Technology Co. | Hu J.,China Institute of Atomic Energy | Hu J.,Atom Hi Technology Co. | And 6 more authors.
Yuanzineng Kexue Jishu/Atomic Energy Science and Technology | Year: 2015

The 99Tcm(CO)3-BPHRGD was prepared, and in-vivo biological evaluations in nude mice bearing M21human melanoma tumor were completed. The labeling yield of 99Tcm(CO)3-BPHRGD is more than 80% under optimal conditions (pH=7, reacting at 75℃ for 30 min), and the radiochemical purity is more than 98% after purification. The in-vitro stability experiments show that the radiolabeled compound has good stability in normal saline and human serum under 37 ℃. The biodistribution of 99Tcm(CO)3-BPHRGD in nude mice bearing M21human melanoma tumor shows that the ratio of tumor/blood is 0.70±0.45, 0.87±0.05, 1.10±0.19 and 1.68±0.04at 0.5, 1, 2and 4h respectively. The ratio of T/NT increases with time. This indicates that the clearance rate of this radiolebeled compound in tumor is slower than in other tissues. Through the further structural modification to change metabolic pathways and pharmacokinetic properties, it is very promising as a new tumor imaging agent. ©, 2015, Atomic Energy Press. All right reserved. Source


Wang X.,China Institute of Atomic Energy | Wang X.,Atom Hi Technology Co. | Cui H.-P.,China Institute of Atomic Energy | Cui H.-P.,Atom Hi Technology Co. | And 8 more authors.
Yuanzineng Kexue Jishu/Atomic Energy Science and Technology | Year: 2015

Nanoparticle SPION-DMSA and its radiolabeled SPION-DMSA-99Tcm were prepared in order to investigate the possibility of SPION-DMSA-99Tcm as a SPECT/MRI dual-modal imaging agent. SPION was synthesized by a hydrothermal process, and then coated with DMSA to afford SPION-DMSA. SPION-DMSA was characterized by means of various methods. SPION-DMSA-99Tcm was obtained by labeling with 99Tcm. The data of biodistribution and the SPECT and MRI images were acquired after injecting SPION-DMSA-99Tcm into the nude mice bearing U87MG human glioma in various intervals. The results show that SPION-DMSA exhibits super-magnetic properties. The labeling yield of SPION-DMSA with 99Tcm was more than 98%. SPION-DMSA-99Tcm is cleared from the blood quickly and has higher uptake in the liver. There was a big difference of biodistributions between SPION-DMSA-99Tcm and DMSA-99Tcm(V) in the nude mice. The uptake of SPION-DMSA-99Tcm in tumor is not obvious. The results of imaging made by MRI and SPECT using SPION-DMSA and SPION-DMSA-99Tcm respectively show that the tumor passive targeting of SPION-DMSA and SPION-DMSA-99Tcm is limited. Therefore, SPION-DMSA-99Tcm is not an ideal SPECT/MRI dual-modal imaging agent for the nude mice bearing U87MG human glioma. ©, 2015, Atomic Energy Press. All right reserved. Source


Wang X.,China Institute of Atomic Energy | Wang X.,Atom Hi Technology Co. | Cui H.-P.,China Institute of Atomic Energy | Cui H.-P.,Atom Hi Technology Co. | And 8 more authors.
Yuanzineng Kexue Jishu/Atomic Energy Science and Technology | Year: 2015

In order to investigate the possibility of SPION-DMSA-RGD-99Tcm as a SPECT/MRI dual-modal imaging agent, SPION-DMSA-RGD and its radiolabeled SPION-DMSA-RGD-99Tcm were prepared. SPION-DMSA-RGD was prepared based on SPION-DMSA and c(RGDfC). SPION-DMSA-RGD was characterized by means of various methods. SPION-DMSA-RGD-99Tcm was given by labeling with 99Tcm. The biodistribution studies of SPION-DMSA-RGD-99Tcm in normal mice and the nude mice bearing U87MG human glioma were performed. The MRI and SPECT imaging of SPION-DMSA-RGD and SPION-DMSA-RGD-99Tcm in the nude mice bearing U87MG human glioma were carried out, respectively. The results show that SPION-DMSA-RGD exhibits super-magnetic properties. The labeling yield of SPION-DMSA-RGD with 99Tcm is about 98%. SPION-DMSA-RGD-99Tcm displays fast clearance from the blood and high accumulation in the liver. The tumor uptake of SPION-DMSA-RGD-99Tcm is higher than that of SPION-DMSA-99Tcm. The MRI and SPECT images show that the tumor active targeting of SPION-DMSA-RGD and SPION-DMSA-RGD-99Tcm are obvious. Therefore, SPION-DMSA-RGD-99Tcm can be acting as a SPECT/MRI dual-modal imaging agent for nude mice bearing U87MG human glioma. © 2015, Editorial Board of Atomic Energy Science and Technology. All right reserved. Source


Qing J.,China Institute of Atomic Energy | Qing J.,Atom Hi Technology Co. | Chen B.-J.,China Institute of Atomic Energy | Luo L.-Z.,Atom Hi Technology Co. | And 6 more authors.
He-Huaxue yu Fangshe Huaxue/Journal of Nuclear and Radiochemistry | Year: 2014

99Tcm(CO)3-BPHRGD was prepared, and the in vitro and in vivo biological evaluations were completed. The labeling yield of 99Tcm(CO)3-BPHRGD is more than 80% under optimal conditions(pH=7, reacting at 75°C for 30 min), and the radiochemical purity is more than 98% after purified. Stability in vitro experiments show that the radiolabeled compound shows good stability in physiological saline, fetal bovine serum, and cysteine solution under 37°C. The biodistribution of 99Tcm(CO)3-BPHRGD in normal mice shows that the metabolic pathways are mainly though liver and kidney with rapid clearance in blood. Source

Discover hidden collaborations