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Samixa Rameshbhai P.,RK University | Samixa Rameshbhai P.,Atmiya Institute of Pharmacy | Chhaganbhai Nanjibhai P.,Shri Sarvajanik Pharmacy College
Asian Journal of Pharmaceutical Research and Health Care | Year: 2013

The present paper describes simple, accurate, rapid, precise and sensitive UV spectrophotometric absorption correction method for the simultaneous determination of amlodipine and aliskiren in combined tablet dosage form. methanol was used as solvent. The wavelengths selected for the analysis using absorption correction method were 354.5 nm and 256.0 nm for estimation of amlodipine and aliskiren respectively. Beer's law obeyed in the concentration range of 10-60 μg/mL and 20-120 μg/mL for amlodipine and aliskiren, respectively. The mean percentage drug content for amlodipine and aliskiren were found to be 99.9. ± 1.38 and 99.87 ± 1.25 respectively and the % RSD value was found to be less than 2 which shows the precision of method. The high recovery and low coefficients of variation conforms the suitability for the routine quality control analysis of amlodipine and aliskiren in pure and pharmaceutical dosage forms.

Bagadiya A.,Atmiya Institute of Pharmacy | Kapadiya M.,Atmiya Institute of Pharmacy | Mehta K.,Atmiya Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

One of the most feasible approaches for oral drug delivery in achieving a prolonged release and predictable drug delivery profile in the gastrointestinal tract (GIT) is to control the gastric residence time (GRT). The dosage forms with prolonged GRT are also known as Gastroretentive Dosage Forms (GRDFs) include intragastric floating systems (low density systems), mucoadhesive systems, high density systems, magnetic systems, unfoldable, extendable or swellable systems and superporous hydrogels (SPHs). Superporous hydrogels (SPHs) were originally developed as a novel drug delivery system for those drugs having absorption window in stomach and upper part of the gastrointestinal tract. These systems should instantly swell in the stomach and maintain their integrity in the harsh stomach environment, while releasing the pharmaceutical active ingredient. The fast swelling property is based on water absorption through open porous structure by capillary force. The poor mechanical strength of SPHs has been overcome by developing the second-generation SPH composites (SPHCs) and the third-generation SPH hybrids (SPHHs). For years, the synthetic features and properties of these SPH materials have been modified and improved to meet the requirements for gastric retention applications. This review discusses the formulation, techniques for synthesizing superporous hydrogel, different generations and drug loading techniques, characterization and literature update of this promising tool.

Patel M.B.,Atmiya Institute of Pharmacy
Journal of complementary & integrative medicine | Year: 2012

The present investigation was aimed at discovery of novel acetylcholinesterase (AChE) inhibitors. In vitro AchE inhibitory activity of various extracts of Sphaeranthus indicus flower heads was carried out. The petroleum ether fraction of S. indicus flowers (SIPE) exhibited significant activity. The fraction was found to be rich in sesquiterpene lactone content possibly responsible for in vitro AChE inhibition. In further study, the antiamnesic activities of SIPE in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) were examined. SIPE (10 mg/kg, p.o.) administration significantly reversed cognitive impairments in mice by passive avoidance test (P < 0.05). It also reduced escape latencies in training trials and prolonged swimming times in the target quadrant during the probe trial in the water maze task (P < 0.05). These results indicated that S. indicus due to its sesquiterpene lactones have anti-cholinesterase activity. A major sesquiterpene lactone, 7-hydroxy frullanolide along with other constituents were isolated from SIPE and evaluated for AchE inhibitory activity. Negative results were obtained in case of isolated compounds. Synergistic effect between constituents of SIPE was confirmed to have anti-amnesic activities that may be useful for cognitive impairment treatment.

Patel M.B.,Atmiya Institute of Pharmacy | Mishra S.M.,M. S. University of Baroda
Journal of Functional Foods | Year: 2012

Antidiabetic potential of Tinospora cordifolia stem is well proven. In the course of screening of useful α-glucosidase inhibitors, we prepared alkaloid fraction (AFTC) and isolated three isoquinoline alkaloids, namely, jatrorrhizine, palmatine and magnoflorine as active candidates for α-glucosidase inhibition. The enzyme kinetics was studied using sucrose and maltose as substrates. Michaelis-Menten constant (K m) and maximal velocity (V max) values were estimated. A significant decrease in V max and unaltered K m was observed in case of jatrorrhizine and palmatine (non-competitive inhibition). Magnoflorine was found to increase apparent K m and shown to be reversible, competitive inhibition. The IC 50 value as sucrase inhibitor was 36.25, 23.46 and 9.8μg/mL for jatrorrhizine, palmatine and magnoflorine, respectively, and as maltase inhibitor was 22.05, 38.42 and 7.6μg/mL for jatrorrhizine, palmatine and magnoflorine, respectively. In vivo studies were conducted on rats to determine oral glucose tolerance test (OGTT), using different substrates: glucose, sucrose and maltose. The increase in plasma glucose level was significantly suppressed (P<0.01) by all the three alkaloids at 20mg/kg b.w. Magnoflorine possessed the most potential activity as α-glucosidase inhibitor in vitro and in vivo. © 2011 Elsevier Ltd.

Gondalia R.P.,Atmiya Institute Of Pharmacy | Dharamsi A.P.,Pioneer India
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

A binary mixture of Naproxen sodium and Sumatriptan succinate was determined by UV spectroscopic methods. The method involved determination of NAP and SUMA using the first derivative spectrophotometry at 241.0 and 236.0 nm over the concentration ranges of 0.5-3.5 μg/ml for both. The methods were successively applied to pharmaceutical formulation because no Spectroscopic interferences from the tablet excipients were found. The suitability of these methods for the quantitative determination of the compounds was proved by validation.

Manvar M.N.,Atmiya Institute of Pharmacy | Desai T.R.,Gujarat University
Indian Journal of Medical Sciences | Year: 2013

Ipomoea aquatica (I. aquatica) (Convolvulaceae) is commonly grown green leafy vegetable found throughout India, Ceylon, Tropical Asia, Africa, and Australia. Traditionally, I. aquatica used as carminative agent and lessens inflammation, and is useful in fever, jaundice, biliousness, bronchitis, liver complaints, etc., I. aquatica is a rich source of vitamins, minerals, proteins, fibers, carotenes, and flavanoids with many health benefits. The objective of this review is to highlight the pharmacognostical, phytochemical, and pharmacological information of this plant.

Patel M.,Atmiya Institute of Pharmacy | Mishra S.,M. S. University of Baroda
Acta Chromatographica | Year: 2012

Methods based on RP-HPLC and HPTLC with UV detection for rapid quantitative determination of marker component in Enicostemma hyssopifolium, swertisin are described. The recovery of the compound was between 96.3-101.5% by HPTLC method and 98.9-100.2% by HPLC assay. The relative standard deviations ranged between 1.53-1.81 (intra-day) and 1.33-1.96 (inter-day) for HPTLC and 0.60-1.11 (intra-day) and 0.80-1.20 (inter-day) for HPLC. The methods were used for routine analysis of swertisin in the aerial parts of the plant. HPTLC method was found to be more economic and less time consuming than HPLC. Reproducibility and recovery in HPLC method were better than that in HPTLC method.

Patel M.B.,Atmiya Institute of Pharmacy
Journal of Herbs, Spices and Medicinal Plants | Year: 2011

A reverse phase-high-performance liquid chromatography method was developed and validated for the estimation of negundoside in Vitex negundoside leaves. Factors influencing negundoside concentration include leaf age, size, drying methods, solvent composition, method of extraction, extraction time, and temperature, all of which were evaluated. Microwave drying caused the least degradation of negundoside during drying. Larger leaves contain a higher amount of negundoside than the smaller ones. Leaves that were 5 weeks old contained the highest concentration of negundoside. Optimized solvent composition of methanol:water (1:1) with microwave drying produced the highest negundoside concentration in the dried leaves. © 2011 Copyright Taylor and Francis Group, LLC.

Batt D.K.,Atmiya Institute of Pharmacy | Garala K.C.,Atmiya Institute of Pharmacy
Journal of Inclusion Phenomena and Macrocyclic Chemistry | Year: 2013

The objective of this research was to improve the aqueous solubility, dissolution rate and, consequently, bioavailability of diacerein, along with avoiding its side effect of diarrhea, by complexation with β-cyclodextrin (β-CD) and HP-β-cyclodextrin (HP-β-CD). Phase solubility curve was classified as an AN type for both the CDs, which indicated formation of complex of diacerein with β-CD and HP-β-CD in 1:1 stoichiometry and demonstrating that both CDs are proportionally less effective at higher concentrations. The complexes were prepared by kneading method and were evaluated to study the effect of complexation on aqueous solubility and rate of dissolution in phosphate buffer (pH 6.8). Based on the dissolution profile HP-β-CD was selected for preparing fast disintegrating tablet of diacerein which was compared with marketed formulation (MF-J). The HP-β-CD complex was probed for Fourier transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction studies which evidenced stable complex formation and increase in amorphousness of diacerein in complex. In brief, the characterization studies confirmed the inclusion of diacerein within the non-polar cavity of HP-β-CD. HP-β-CD complex showed improved in vitro drug release profile compared to pure drug and similar to that of marketed formulation respectively. © Springer Science+Business Media Dordrecht 2012.

Kanani M.H.,R K University | Kanani M.H.,Atmiya Institute of pharmacy | Vadalia K.R.,Atmiya Institute of pharmacy
International Journal of Pharma and Bio Sciences | Year: 2015

Exemestane is oral-steroidal Aromatase inhibitors. EXE chemotherapy treatment is often associated with a number of drawbacks, like nonselective distribution, early drug degradation, undesirable side effect. However, alternative formulations are needed to overcome the serious side effects, and to improve clinical efficacy of the drug. The aim of this work was to prepare poly-e{open}-caprolactone nanoparticle of Exemestane by nanoprecipitation and to characterize them. Percentage of drug (with respect to polymer) was selected as formulation variable. Nanoparticles of Exe were obtained with high encapsulation efficiency. The particle size range was about 37.81-319.9 nm and carried an overall negative surface charge. FT-IR and DSC study indicated no drug and polymer interaction. SEM and TEM image shows non-aggregated and spherical shaped NPs. Percentage of drug significantly influenced particle size, entrapment efficiency and release. The system sustained release of EXE significantly and further investigation could exhibit its potential usefulness in breast cancer therapy.

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