Atmiya Institute of Pharmacy

Rājkot, India

Atmiya Institute of Pharmacy

Rājkot, India
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Patel J.,Atmiya Institute of Pharmacy | Patel A.,Atmiya Institute of Pharmacy | Raval M.,Saurashtra University | Sheth N.,Saurashtra University
Journal of Advanced Pharmaceutical Technology and Research | Year: 2011

Irbesartan (IRB) is an angiotensin II receptor blocker antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water-soluble IRB. The solubility of IRB in various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. The optimized SNEDDS formulation contained IRB (75 mg), Cremophor® EL (43.33%), Carbitol® (21.67%) and Capryol® 90 (32%). SNEDDS was further evaluated for its percentage transmittance, emulsification time, drug content, phase separation, dilution, droplet size and zeta potential. The optimized formulation of IRB-loaded SNEDDS exhibited complete in vitro drug release in 15 min as compared with the plain drug, which had a limited dissolution rate. It was also compared with the pure drug solution by oral administration in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of IRB from SNEDDS compared with the pure drug solution. These results suggest the potential use of SNEDDS to improve dissolution and oral bioavailability of poorly water-soluble IRB.

Basu B.,Atmiya Institute of Pharmacy | Aviya K.R.,Atmiya Institute of Pharmacy | Bhattacharya A.,Macleods Pharmaceuticals Ltd.
Journal of Pharmaceutical Investigation | Year: 2014

Prednisolone is a glucocorticoid with the general properties of the corticosteroids. It is used as anti-inflammatory or immunosuppressive agent in asthmatic condition mostly in pediatric and geriatric population. So the present investigation was conducted with an aim of to formulate a taste masked patient friendly dosage form i.e. mouth dissolving tablets of prednisolone. In this study, taste masking of drug was critical parameter for this study. Masking of bitter taste of prednisolone was carried out using techniques like preparation of solid dispersion with PEG 6000, complex formation with Indion-204 resin and β-cyclodextrin. Among them complex prepared from β-cyclodextrin in weight ratio 1:4 was optimized basis on taste panel evaluation and drug release from complex. A successful taste masking of complex was confirmed by time intensity method and also by taking drug release in simulated gastric fluid and in simulated salivary fluid. The values of pre-compression parameters evaluated, were within prescribed limits and indicated good free flowing properties. Tablets optimization was carried out through 32 full factorial designs, concentration of superdisintegrants like croscarmellose sodium and sodium starch glycolate as independent variable. Whereas wetting time, disintegrating time and cumulative percentage of drug release as dependent variable. The data obtained of post-compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution was found within specified limit. Prepared check point batch having disintegrating time 16.12 s and drug release 98.34 after 30 min was selected as optimized formula. This formula was compared with marketed formulation and was found better disintegration and drug release property. Optimized formulation was subjected for accelerated stability study as per ICH guideline. © 2013 The Korean Society of Pharmaceutical Sciences and Technology.

Vipul V.,Atmiya Institute of Pharmacy | Basu B.,Atmiya Institute of Pharmacy
International Journal of Drug Delivery | Year: 2013

The present study mainly focuses on the novel floating in-situ gelling system for controlled delivery of ramipril. Ramipril has half-life of 2-4 hours and required dose is 10 mg day. Hence ramipril is a suitable candidate for sustained drug delivery system. A gastro retentive drug delivery system of ramipril was formulated to increase the resident time in stomach and to modulate the release behavior of the ramipril. Different formulations of ramipril were prepared by using different concentration of gelling polymer such as sodium alginate, gellan gum and calcium carbonate. Sodium citrate was used to prevent gelation outside the gastric environment. The formulation was studied for FT-IR study and DSC study to interpret the interaction between drug and polymer used. Formulation containing 0.50 % of sodium alginate, 0.50 % of gellan gum and 1.0 % of calcium carbonate showed the best gelling ability. For optimization of in-situ gelling system 32 full factorial design was employed to study the effect of independent variables, concentration of gellan gum (X1) and concentration of sodium alginate (X2) and dependent variables like viscosity, in vitro bouncy time, % drug release at 4 hr (Y3), % drug release at 6 hr (Y4) and % drug release at 8 hr (Y5). F8 batch was selected as optimized batch based on buoyancy time (71 sec), viscosity 356.9cp, drug content 99.06 % and CPR 99.80 % at 12 hrs. The controlled release of ramipril from in-situ gelling system was observed and good fit to the Zero order and Korsmeyer Peppasmodel whichshows fickian diffusion (n=0.351) mechanism. Stability revealed that there was no noticeable change in characterizations. Thus, in-situ gel formulation is promising approach for gastroretentive controlled delivery of Ramipril.

Patel M.B.,Atmiya Institute of Pharmacy
Journal of complementary & integrative medicine | Year: 2012

The present investigation was aimed at discovery of novel acetylcholinesterase (AChE) inhibitors. In vitro AchE inhibitory activity of various extracts of Sphaeranthus indicus flower heads was carried out. The petroleum ether fraction of S. indicus flowers (SIPE) exhibited significant activity. The fraction was found to be rich in sesquiterpene lactone content possibly responsible for in vitro AChE inhibition. In further study, the antiamnesic activities of SIPE in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) were examined. SIPE (10 mg/kg, p.o.) administration significantly reversed cognitive impairments in mice by passive avoidance test (P < 0.05). It also reduced escape latencies in training trials and prolonged swimming times in the target quadrant during the probe trial in the water maze task (P < 0.05). These results indicated that S. indicus due to its sesquiterpene lactones have anti-cholinesterase activity. A major sesquiterpene lactone, 7-hydroxy frullanolide along with other constituents were isolated from SIPE and evaluated for AchE inhibitory activity. Negative results were obtained in case of isolated compounds. Synergistic effect between constituents of SIPE was confirmed to have anti-amnesic activities that may be useful for cognitive impairment treatment.

Patel M.B.,Atmiya Institute of Pharmacy | Mishra S.M.,M. S. University of Baroda
Journal of Functional Foods | Year: 2012

Antidiabetic potential of Tinospora cordifolia stem is well proven. In the course of screening of useful α-glucosidase inhibitors, we prepared alkaloid fraction (AFTC) and isolated three isoquinoline alkaloids, namely, jatrorrhizine, palmatine and magnoflorine as active candidates for α-glucosidase inhibition. The enzyme kinetics was studied using sucrose and maltose as substrates. Michaelis-Menten constant (K m) and maximal velocity (V max) values were estimated. A significant decrease in V max and unaltered K m was observed in case of jatrorrhizine and palmatine (non-competitive inhibition). Magnoflorine was found to increase apparent K m and shown to be reversible, competitive inhibition. The IC 50 value as sucrase inhibitor was 36.25, 23.46 and 9.8μg/mL for jatrorrhizine, palmatine and magnoflorine, respectively, and as maltase inhibitor was 22.05, 38.42 and 7.6μg/mL for jatrorrhizine, palmatine and magnoflorine, respectively. In vivo studies were conducted on rats to determine oral glucose tolerance test (OGTT), using different substrates: glucose, sucrose and maltose. The increase in plasma glucose level was significantly suppressed (P<0.01) by all the three alkaloids at 20mg/kg b.w. Magnoflorine possessed the most potential activity as α-glucosidase inhibitor in vitro and in vivo. © 2011 Elsevier Ltd.

Gondalia R.P.,Atmiya Institute Of Pharmacy | Dharamsi A.P.,Pioneer India
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

A binary mixture of Naproxen sodium and Sumatriptan succinate was determined by UV spectroscopic methods. The method involved determination of NAP and SUMA using the first derivative spectrophotometry at 241.0 and 236.0 nm over the concentration ranges of 0.5-3.5 μg/ml for both. The methods were successively applied to pharmaceutical formulation because no Spectroscopic interferences from the tablet excipients were found. The suitability of these methods for the quantitative determination of the compounds was proved by validation.

Manvar M.N.,Atmiya Institute of Pharmacy | Desai T.R.,Gujarat University
Indian Journal of Medical Sciences | Year: 2013

Ipomoea aquatica (I. aquatica) (Convolvulaceae) is commonly grown green leafy vegetable found throughout India, Ceylon, Tropical Asia, Africa, and Australia. Traditionally, I. aquatica used as carminative agent and lessens inflammation, and is useful in fever, jaundice, biliousness, bronchitis, liver complaints, etc., I. aquatica is a rich source of vitamins, minerals, proteins, fibers, carotenes, and flavanoids with many health benefits. The objective of this review is to highlight the pharmacognostical, phytochemical, and pharmacological information of this plant.

Patel M.,Atmiya Institute of Pharmacy | Mishra S.,M. S. University of Baroda
Acta Chromatographica | Year: 2012

Methods based on RP-HPLC and HPTLC with UV detection for rapid quantitative determination of marker component in Enicostemma hyssopifolium, swertisin are described. The recovery of the compound was between 96.3-101.5% by HPTLC method and 98.9-100.2% by HPLC assay. The relative standard deviations ranged between 1.53-1.81 (intra-day) and 1.33-1.96 (inter-day) for HPTLC and 0.60-1.11 (intra-day) and 0.80-1.20 (inter-day) for HPLC. The methods were used for routine analysis of swertisin in the aerial parts of the plant. HPTLC method was found to be more economic and less time consuming than HPLC. Reproducibility and recovery in HPLC method were better than that in HPTLC method.

Patel M.B.,Atmiya Institute of Pharmacy
Journal of Herbs, Spices and Medicinal Plants | Year: 2011

A reverse phase-high-performance liquid chromatography method was developed and validated for the estimation of negundoside in Vitex negundoside leaves. Factors influencing negundoside concentration include leaf age, size, drying methods, solvent composition, method of extraction, extraction time, and temperature, all of which were evaluated. Microwave drying caused the least degradation of negundoside during drying. Larger leaves contain a higher amount of negundoside than the smaller ones. Leaves that were 5 weeks old contained the highest concentration of negundoside. Optimized solvent composition of methanol:water (1:1) with microwave drying produced the highest negundoside concentration in the dried leaves. © 2011 Copyright Taylor and Francis Group, LLC.

Batt D.K.,Atmiya Institute of Pharmacy | Garala K.C.,Atmiya Institute of Pharmacy
Journal of Inclusion Phenomena and Macrocyclic Chemistry | Year: 2013

The objective of this research was to improve the aqueous solubility, dissolution rate and, consequently, bioavailability of diacerein, along with avoiding its side effect of diarrhea, by complexation with β-cyclodextrin (β-CD) and HP-β-cyclodextrin (HP-β-CD). Phase solubility curve was classified as an AN type for both the CDs, which indicated formation of complex of diacerein with β-CD and HP-β-CD in 1:1 stoichiometry and demonstrating that both CDs are proportionally less effective at higher concentrations. The complexes were prepared by kneading method and were evaluated to study the effect of complexation on aqueous solubility and rate of dissolution in phosphate buffer (pH 6.8). Based on the dissolution profile HP-β-CD was selected for preparing fast disintegrating tablet of diacerein which was compared with marketed formulation (MF-J). The HP-β-CD complex was probed for Fourier transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction studies which evidenced stable complex formation and increase in amorphousness of diacerein in complex. In brief, the characterization studies confirmed the inclusion of diacerein within the non-polar cavity of HP-β-CD. HP-β-CD complex showed improved in vitro drug release profile compared to pure drug and similar to that of marketed formulation respectively. © Springer Science+Business Media Dordrecht 2012.

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