Trowbridge, United Kingdom
Trowbridge, United Kingdom
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Patent
Atlas Genetics | Date: 2017-07-26

A method of detecting the presence of Neisseria gonorrhoeaein a sample. The method involves detecting a first target sequence taken from the NGO1642 gene and/or a second target sequence taken from the NGO1012 gene. The method may involve a step of amplifying the target sequence, and may involve hybridising the target sequence to a nucleic acid probe and identifying hybridisation. The method may involve simultaneous detection of other target sequences, e.g.from other pathogens.


Patent
Atlas Genetics | Date: 2017-03-22

A system and method for processing fluid in a fluidic cartridge is provided. The system comprises a fluid pathway for passing a liquid sample therethrough from an upstream end to a downstream end, a sample processing chamber within the fluid pathway having an inlet valve upstream of the sample processing chamber, a downstream sample processing region within the fluid pathway downstream of the outlet valve and a bypass channel coupled to the fluid pathway at a junction between the outlet valve and the downstream sample processing region, the valve system configured such that surplus liquid downstream of the outlet valve may be evacuated through the bypass channel when the outlet valve is closed, thereby leaving a metered volume of liquid sample between the inlet valve and the downstream sample processing region.


Patent
Atlas Genetics | Date: 2014-07-28

A valve for a fluidic cartridge is provided. The valve comprises a valve cavity having first and second openings connected to first and second passageways, respectively; and a flexible membrane within the valve cavity, the flexible membrane having a first portion actuatable to seal against the first opening and a second portion actuatable to seal against the second opening; wherein the valve cavity is configured such that the first flexible membrane portion may be actuated independently of the second flexible membrane portion to enable the first opening to be sealed independently of the second.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Small Business Research Initiative | Award Amount: 149.91K | Year: 2016

A Rapid Stratified Medicine Diagnostic Test To Direct Treatment For Symptomatic Patients Presenting In Sexual Health Clinics Atlas Genetics will develop a rapid point-of-care (PoC) stratified medicine diagnostic (SMD) for patients presenting to Sexual Health Clinics with genital discharge syndrome, to allow immediate and accurate selection of appropriate and effective antibiotic treatment. The development and design of the diagnostic will be supported by validated cost-effectiveness modelling of introducing this multi-pathogen PoC-SMD test as well as a study on its potential patient impact. This supporting work will be carried out by the Applied Diagnostic Research and Evaluation Unit (ADREU) at St George’s, University of London (SGUL) in collaboration with Aquarius Population Health. In addition, preliminary work will build on the experience established at Atlas in the implementation of multiplex assays on the io™ Point Of Care platform to assess the challenges involved in expanding multiplexing to include at least four pathogens on a single rapid testing cartridge required for implementation of the proposed stratified medicine diagnostics. At the end of Phase 1, the value to the NHS of a SMD in sexual health will become apparent and the technical path will be established for development and evaluation in Phase 2.


Patent
Atlas Genetics | Date: 2014-07-28

A fluidic cartridge for processing a liquid sample comprises a main channel for passing the liquid sample therethrough from an upstream end to a downstream end; and one or more branch channels that join the main channel for introducing liquid and gas into the main channel after the liquid sample has passed downstream of the one or more branch channels. The one or more branch channels including a first branch channel, wherein the first branch channel comprises: a gas inlet for introducing a gas into the first branch channel; a liquid inlet for introducing a liquid into the first branch channel; and a valve configured to move between a closed position in which it prevents liquid and gas in the first branch channel from passing into the main channel and an open position in which it permits liquid and gas in the first branch channel to pass into the main channel.


Patent
Atlas Genetics | Date: 2014-07-28

A system and method for processing fluid in a fluidic cartridge is provided. The system comprises a fluid pathway for passing a liquid sample therethrough from an upstream end to a downstream end, a sample processing chamber within the fluid pathway having an inlet valve upstream of the sample processing chamber, a downstream sample processing region within the fluid pathway downstream of the outlet valve and a bypass channel coupled to the fluid pathway at a junction between the outlet valve and the downstream sample processing region, the valve system configured such that surplus liquid downstream of the outlet valve may be evacuated through the bypass channel when the outlet valve is closed, thereby leaving a metered volume of liquid sample between the inlet valve and the downstream sample processing region.


Patent
Atlas Genetics | Date: 2015-09-04

The invention provides a method of probing for a nucleic acid comprising: contacting a nucleic acid solution with an oligonucleotide probe labelled with an electrochemically active marker, providing conditions at which the probe is able to at least partially hybridise with any complementary target sequence which may be present in the nucleic acid solution, selectively degrading either hybridised, partially hybridised or unhybridised nucleic acid probe, and electrochemically determining information relating to the electrochemically active marker. The invention further provides novel molecules with use in methods of the invention.


Patent
Atlas Genetics | Date: 2015-08-05

The invention provides a method of probing for a nucleic acid comprising: contacting a nucleic acid solution with an oligonucleotide probe labelled with an electrochemically active marker, providing conditions at which the probe is able to at least partially hybridise with any complementary target sequence which may be present in the nucleic acid solution, selectively degrading either hybridised, partially hybridised or unhybridised nucleic acid probe, and electrochemically determining information relating to the electrochemically active marker. The invention further provides novel molecules with use in methods of the invention.


The invention provides a method of probing for a nucleic acid comprising: contacting a nucleic acid solution with an oligonucleotide probe labelled with an electrochemically active marker, providing conditions at which the probe is able to at least partially hybridise with any complementary target sequence which may be present in the nucleic acid solution, selectively degrading either hybridised, partially hybridised or unhybridised nucleic acid probe, and electrochemically determining information relating to the electrochemically active marker. The invention further provides novel molecules with use in methods of the invention.


Patent
Atlas Genetics | Date: 2014-07-18

A method of nucleic acid amplification involving using a first modified primer which provides protection to the amplification product from exonuclease degradation and a second primer. The method provides a double stranded nucleic acid, one strand of which is degraded by a double strand nucleic acid specific exonuclease to form a single stranded nucleic acid, which is protected from exonuclease degradation.

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