Atish Dipankar University Of Science And Technology or is a private university in Banani, Dhaka, Bangladesh. The university was named after Atish Dipankara Srijnana, the ancient Buddhist scholar. ADUST was authorized by the Private University Act 1992. The university was established in 2004, after getting approval from the University Grants Commission Bangladesh. It was supported by Bangladesh President Iajuddin Ahmed. ADUST provides education in the following fields of study: Agriculture, Biological Science & Biotechnology, Arts and Social Science, Computer Science & Technology, and Business and Economics. Wikipedia.
Alam B.,Kyungpook National University |
Alam B.,Atish Dipankar University of Science and Technology |
Majumder R.,Atish Dipankar University of Science and Technology |
Akter S.,Atish Dipankar University of Science and Technology |
Lee S.-H.,Kyungpook National University
Oncology Letters | Year: 2015
The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells into mice, extracts were administered at 25, 50 and 100 mg/kg body weight for nine consecutive days. The antitumor effects of the extracts were then assessed according to tumor volume, packed cell count, viable and non-viable tumor cell count, median survival time and increase in life span of EAC-bearing mice. Next, hematological profiles and serum biochemical parameters were calculated, and antioxidant properties were assessed by estimating lipid peroxidation, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels. MPBL and the ethylacetate fraction (EPBL) at a dose of 100 mg/kg induced a significant decrease in tumor volume, packed cell volume and viable cell count and increased the life span of the EAC-bearing mice (P<0.05). Hematological and serum biochemical profiles were restored to normal levels in the extract-treated mice compared with the EAC control mice. MPBL and EPBL treatment significantly decreased lipid peroxidation (P<0.05) and restored GSH, SOD and CAT levels towards normal compared with the EAC control. Taken together, the results of the present study demonstrated that Piper betle extracts exhibit significant antitumor activity, which may be attributed to the augmentation of endogenous antioxidant potential. © 2015, Spandidos Publications. All rights reserved.
PubMed | Noakhali Science and Technology University and Atish Dipankar University of Science and Technology
Type: Journal Article | Journal: Asian Pacific journal of tropical biomedicine | Year: 2014
To study the phytochemical and biological properties (antioxidant, anthelmintic and thrombolytic) of methanolic extracts of Enhydra fluctuans Lour., a plant belonging to the Asteraceae family.The phytochemical evaluation was carried out by qualitative analysis. In vitro antioxidant activity of extract was studied using free radical scavenging assay, ability of reduction, total phenol and total flavonoid contents determination assays. The anthelmintic activity was determined using paralysis and death time of Pheretima posthuma (earthworm) and thrombolytic activity by clot disruption assay.The phytochemical evaluation showed significant presence of flavonoids, triterpenes, carbohydrate, reducing sugars, saponins, phenols, diterpenes, protein and tannin. The antioxidant activity was found significant [IC50=(135.200.56) g/mL] as compared to ascorbic acid [(130.000.76) g/mL]. The reducing power was increased with concentration. Total phenol and total flavonoid contents were (153.080.38) mg/mL and (172.040.56) mg/mL respectively. The paralysis and death time of earthworms for different concentrations of extract were determined and compared with albendazole. The results showed that 10 mg/mL of the crude extract had similar effect with albendazole. Additionally, the crude extract showed a concentration depended relationship with its anthelmintic property. The clot lysis activity of crude extract was compared to the standard streptokinases clot lysis (40.13%) activity and found significant (31%).The study proves that the crude methanolic extract of Enhydra fluctuans Lour. has significant antioxidant, anthelmintic and thrombolytic activity containing wide range of phytochemicals.
Kuri S.,Noakhali Science and Technology University |
Billah M.M.,Noakhali Science and Technology University |
Masud Rana S.M.,Noakhali Science and Technology University |
Naim Z.,Atish Dipankar University of Science and Technology |
And 4 more authors.
Asian Pacific Journal of Tropical Biomedicine | Year: 2014
Objective: To study the phytochemical and biological properties (antioxidant, anthelmintic and thrombolytic) of methanolic extracts of Enhydra fluctuans Lour., a plant belonging to the Asteraceae family. Methods: The phytochemical evaluation was carried out by qualitative analysis. In vitro antioxidant activity of extract was studied using free radical scavenging assay, ability of reduction, total phenol and total flavonoid contents determination assays. The anthelmintic activity was determined using paralysis and death time of Pheretima posthuma (earthworm) and thrombolytic activity by clot disruption assay. Results: The phytochemical evaluation showed significant presence of flavonoids, triterpenes, carbohydrate, reducing sugars, saponins, phenols, diterpenes, protein and tannin. The antioxidant activity was found significant [IC50=(135.20±0.56) μg/mL] as compared to ascorbic acid [(130.00±0.76) μg/mL]. The reducing power was increased with concentration. Total phenol and total flavonoid contents were (153.08±0.38) mg/mL and (172.04±0.56) mg/mL respectively. The paralysis and death time of earthworms for different concentrations of extract were determined and compared with albendazole. The results showed that 10 mg/mL of the crude extract had similar effect with albendazole. Additionally, the crude extract showed a concentration depended relationship with its anthelmintic property. The clot lysis activity of crude extract was compared to the standard streptokinase's clot lysis (40.13%) activity and found significant (31%). Conclusions: The study proves that the crude methanolic extract of Enhydra fluctuans Lour. has significant antioxidant, anthelmintic and thrombolytic activity containing wide range of phytochemicals. © 2014 by the Asian Pacific Journal of Tropical Biomedicine.
Rahman M.,Chiba University |
Ullah R.,Atish Dipankar University of Science and Technology |
Lan M.,Chiba University |
Sri Sumantyo J.T.,Chiba University |
And 2 more authors.
International Journal of Remote Sensing | Year: 2013
Remote-sensing images taken from the Landsat Enhanced Thematic Mapper Plus (ETM+) sensor with a spatial resolution of 30 m were applied for mapping and inventory of mangrove forest areas in Sundarbans, on both sides of the border between Bangladesh and India. Three different classification methods - unsupervised classification with k-means clustering, supervised classification using the maximum likelihood decision rule, and band-ratio supervised classification - were tested and compared in terms of the top of the atmosphere reflectance images. Spectral signature and principal component analyses were applied to select the appropriate band combinations prior to the band ratio-supervised classification. Our results show that the band ratio method is superior to the unsupervised or supervised classification methods considering the visual inspection, producer's and user's accuracy, as well as the overall accuracy of the all the classes in the image. The best discrimination of mangrove/nonmangrove boundary can be achieved when the combinations of B4/B2 (band 4/band 2), B5/B7, and B7/B4 are employed from the ETM+ bands. © 2013 Copyright Taylor and Francis Group, LLC.
PubMed | Northern University of Bangladesh, Manarat International University, Chemical Research Division and Atish Dipankar University of Science and Technology
Type: | Journal: Evidence-based complementary and alternative medicine : eCAM | Year: 2015
Cnicus arvensis is used by many ethnic groups for inflammation, pain, and other ailments. In this study, reducing sugar, carbohydrate, alkaloid, steroid, tannin, flavonoid, and saponin groups were identified using standard chromogenic method. In high-performance liquid chromatography, vanillic acid and epicatechin were identified in the extract. Antinociceptive test by acetic acid induced writhing inhibition resulted 43.17 and 95.08% inhibition for 100 and 200mg/kg body weight, comparing with standard diclofenac Na with 74.86% inhibition for 25mg/kg body weight. In formalin induced paw licking test for antinociceptive activity, the extract inhibited 69.87 and 75.55% licking for 150 and 300mg/kg body weight comparing with the inhibition (68.56%) of diclofenac Na for 10mg/kg body weight at first phase. At late phase, the extract showed 73.12 and 87.46% licking comparing with licking inhibition (71.69%) by diclofenac Na at the same dose. In open field test for CNS depressant activity, the extract showed depression of locomotor activity for 150 and 300mg/kg body weight comparing with diazepam for 10mg/kg body weight. All results were statistically significant (P < 0.01). The identified polyphenols are reputed for antinociceptive and CNS depressant activity. The present findings support the use of this plant in pain.
PubMed | Chittagong University and Atish Dipankar University of Science and Technology
Type: Journal Article | Journal: Biomedical journal | Year: 2017
Human Adenoviruses are divided into 7 species of Human Adenovirus A to G based on DNA genome homology. The Human Adenovirus E (HAdVs-E) genome is a linear, double-stranded DNA containing 38 protein-coding genes. Wild-type adenoviruses type E,are linked to a number of slight illnesses. The most important part of HAdVs-E is E3 CR1-beta protein which controls the host immune response and viral attachment.We use numerous bio-informatics and immuno-informatics implements comprising sequence and construction tools for construction of 3D model and epitope prediction for HAdVs-E.The 3D structure of E3 CR1-beta protein was generated and total of ten antigenic B cell epitopes, 6 MHC class I and 11 MHC class II binding peptides were predicted.The study was carried out to predict antigenic determinants/epitopes of the E3 CR1-beta protein of Human Adenovirus E along with the 3D protein modeling. The study revealed potential T-cell and B-cell epitopes that can raise the desired immune response against E3 CR1-beta protein and useful in developing effective vaccines against HAdVs-E.
Hossain M.M.,Yeungnam University |
Shima H.,University of Rajshahi |
Islam Md.A.,Atish Dipankar University of Science and Technology |
Hasan M.,Yeungnam University |
Lee M.,Yeungnam University
Journal of Physical Chemistry C | Year: 2016
Semiconducting ZnO was used as a surface-enhanced Raman scattering (SERS) substrate without needing to combine it with novel metal particles. An interesting synergistic effect in the Raman scattering of ZnO nanoparticles and CNTs was observed due to the vibrational force of Zn and O atoms in the Zn-O system of ZnO nanoparticles and the special deformation of CNTs in the SERS fiber. The convenient deformation of CNTs allowed a large number of carbon atoms in the planar direction, such as a graphene sheet, and facilitated the planar vibrations of sp2 carbon atoms, leading to a considerable increase in the G and 2D band intensity. A new radial breathing mode (RBM) peak was activated by the radial polarization of CNTs through the vibration force of Zn and O atoms in the Zn-O system in its radial direction. The cross-section cutting 3D image of the SERS fiber revealed the CNTs to be rearranged geometrically in the SERS fiber and formed a bunched structure because of the enhanced interactions among the individual CNTs via ZnO nanoparticles. This highlights a new dimension of research into ZnO nanomaterials and CNTs in SERS fibers and provides new insights into ZnO-CNT fiber composites. © 2016 American Chemical Society.
Islam M.R.,University of Newcastle |
Khan I.,Dhaka Medical College |
Hassan S.M.N.,Atish Dipankar University of Science and Technology |
McEvoy M.,University of Newcastle |
And 6 more authors.
Environmental Health: A Global Access Science Source | Year: 2012
Background: Chronic exposure to high level of inorganic arsenic in drinking water has been associated with Type 2 Diabetes (T2D). Most research has been ecological in nature and has focused on high levels of arsenic exposure with few studies directly measuring arsenic levels in drinking water as an index of arsenic exposure. The effect of low to moderate levels of arsenic exposure on diabetes risk is largely unknown thus our study is adding further knowledge over previous works. Methods: This cross sectional study was conducted in 1004 consenting women and men from 1682 eligible participants yielding a participation rate of 60%. These participants are aged >30 years and were living in Bangladesh and had continuously consumed arsenic-contaminated drinking water for at least 6 months. T2D cases were diagnosed using glucometer following the new diagnostic criteria (Fasting Blood Glucose > 126 mg/dl) from the WHO guideline (WHO 2006), or a self-reported physician diagnosis of type 2 diabetes. Association between T2D and chronic arsenic exposure was estimated by multiple logistic regression with adjustment for age, sex, education, Body Mass Index (BMI) and family history of T2D. Results: A total of 1004 individuals participated in the study. The prevalence of T2D was 9% (95% CI 7-11%). After adjustment for diabetes risk factors, an increased risk of type 2 diabetes was observed for arsenic exposure over 50 μg/L with those in the highest category having almost double the risk of type 2 diabetes (OR=1.9 ; 95% CI 1.1-3.5). For most levels of arsenic exposure, the risk estimates are higher with longer exposure; a doseresponse pattern was also observed. Conclusions: These findings suggest an association between chronic arsenic exposure through drinking water and T2D. Risks are generally higher with longer duration of arsenic exposure. The risk of T2D is highest among those who were exposed to the highest concentration of arsenic for more than 10 years. © 2012 Voutsadakis; licensee BioMed Central Ltd.
Zahan R.,University of Rajshahi |
Nahar L.,University of Rajshahi |
Nesa L.,Atish Dipankar University of Science and Technology
Pakistan Journal of Biological Sciences | Year: 2013
The present study aimed to evaluate the antinociceptive and anti-inflammatory activity of Alangium salvifolium (AS) flower in mice. The antinociceptive activity was determined using tail immerson, acetic acid induced writhing and formalin induced licking test. Antiinflammatory effects were evaluated using carrageenan and formalin induced paw edema in mice. The methanol extract (50 and 100 mg kg-1) of flower of AS followed by chloroform extract (100 mg kg-1) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mice writhing induced by acetic acid and delayed the response of mice to hot water thermal stimulation in tail immersion test. All flowers extract of AS also produced a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw edema. The inhibitions were similar to those produced by indomethacin, p.o. The different alkaloids and flavonoids found in the extract could be account for the antinociceptive and anti-inflammatory actions. © 2013 Asian Network for Scientific Information.
Badrul Alam M.,Atish Dipankar University of Science and Technology |
Saifur Rahman M.,Atish Dipankar University of Science and Technology |
Hasan M.,Atish Dipankar University of Science and Technology |
Maruf Khan M.,Atish Dipankar University of Science and Technology |
And 2 more authors.
International Journal of Pharmacology | Year: 2012
Dillenia indica Linn. (Dilleniaceae) is widely used as food and reputed in the folk medicine of Bangladesh and India in particular, to relieve pain associated with gastrointestinal disturbance. Methanolic extract of the bark of Dillenia indica Linn. (MDI) was subjected to evaluate for its analgesic and antioxidant properties. The analgesic activity of MDI (200 and 400 mg kg -1 b.wt. p.o.) was determined for its central and peripheral pharmacological actions using hotplate as well as tail immersion method and acetic acid-induced writhing test with formalin induced pain in mice, respectively. To evaluate antioxidant potential of MDI, total antioxidant activity, scavenging of l,l-diphenyl-2-picrylhydrazyl (DPPH) radical as well as total Reactive Oxygen Species (ROS) and assessment of reducing power were used. The extract, at the dose of 200 and 400 mg kg -1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods whereas significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. In DPPH and total ROS scavenging method, MDI showed good antioxidant potentiality with the IC 50 value of 12.32±0.16 and 34.72±0.48 μg mL -1, respectively with a good reducing power. The findings of the study suggested that MDI has strong analgesic and antioxidant effects, conforming the traditional use of this plant for pain alleviation to its antioxidant potentiality © 2012 Asian Network for Scientific Information.