Atish Dipankar University of Science and Technology
Dhaka, Bangladesh

Atish Dipankar University Of Science And Technology or is a private university in Banani, Dhaka, Bangladesh. The university was named after Atish Dipankara Srijnana, the ancient Buddhist scholar. ADUST was authorized by the Private University Act 1992. The university was established in 2004, after getting approval from the University Grants Commission Bangladesh. It was supported by Bangladesh President Iajuddin Ahmed. ADUST provides education in the following fields of study: Agriculture, Biological Science & Biotechnology, Arts and Social Science, Computer Science & Technology, and Business and Economics. Wikipedia.

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Chowdhury N.S.,Manarat International University | Alam M.B.,Atish Dipankar University of Science and Technology | Tanbirul Haque A.S.M.,Atish Dipankar University of Science and Technology | Zahan R.,Atish Dipankar University of Science and Technology | And 2 more authors.
Global Journal of Pharmacology | Year: 2011

Investigation with the crude methanolic extract of Aponogeton undulatus was carried out to evaluate its possible antioxidant and thrombolysis activity. In DPPH free radical scavenging assay, the extract exhibited potent antioxidant activity with a IC50 values of 2.43±1.06 μg/ml while in ascorbic acid, the value become 50 2.14±0.11 μg/ml. In thrombolytic activity using in vitro clot lysis assay method, the crude methanolic extract was found to have significant (p<0.001) thrombolytic activity at a dose of 10 mg/ml with a miximum effect of 20.23±1.56% while the standard streptokinase showed 46.13±3.87%. The extract was also investigated for its antibacterial and toxic potentiality using agar diffusion and Brine Shrimp lethality bioassay, respectively. The highest antibacterial effect was shown against Bacillus cereus (zone of inhibition 12±0.65 mm) followed by Escherichia coli (zone of inhibition 10±0.71 mm). In this bioassay the extract showed significant toxicity to Brine Shrimp nauplii with the LC50 value of 2.24±0.98 μg/ml. The study clearly indicated that the extract 50 possesses good antioxidant and thromolytic activity along with broad spectrum antibacterial and toxic potentiality. © IDOSI Publications, 2011.

Alam B.,Atish Dipankar University of Science and Technology | Hossain S.,Atish Dipankar University of Science and Technology | Habib R.,East West University of Bangladesh | Rea J.,Square Pharmaceutical Ltd | Islam A.,Bangladesh University
International Journal of Pharmacology | Year: 2012

Methanolic extract of Lannea coromandelica Linn, bark (MLCB) was subjected to evaluate its antioxidant and analgesic properties. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate as well as tail immersion method and acetic acid-induced writhing test with formalin induced pain in mice, respectively. To evaluate antioxidant potential of MLCB, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical as well as total Reactive Oxygen Species (ROS) and assessment of reducing power were used. The extract, at the dose of 200 and 400 mg kg-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods whereas significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. In DPPH and total ROS scavenging method, MLCB showed good antioxidant potentiality with the IC50 value of 12.32±0.16 and 34.72±0.48 μg mL-1, respectively with a good reducing power. In conclusion this study demonstrated the strong antioxidant and antinociceptive activities of methanolic extract of the bark of L. coromandelica. Altogether, these results suggest that the MLCB could be used as a potential antinociceptive agent along with its antioxidant potentiality. © 2012 Asian Network for Scientific Information.

Hossain M.M.,Yeungnam University | Islam M.A.,Atish Dipankar University of Science and Technology | Shima H.,University of Rajshahi | Hasan M.,King Khalid University | Lee M.,Yeungnam University
ACS Applied Materials and Interfaces | Year: 2017

This is the first study that describes how semiconducting ZnO can act as an alignment agent in carbon nanotubes (CNTs) fibers. Because of the alignment of CNTs through the ZnO nanoparticles linking groups, the CNTs inside the fibers were equally distributed by the attraction of bonding forces into sheetlike bunches, such that any applied mechanical breaking load was equally distributed to each CNT inside the fiber, making them mechanically robust against breaking loads. Although semiconductive ZnO nanoparticles were used here, the electrical conductivity of the aligned CNT fiber was comparable to bare CNT fibers, suggesting that the total electron movement through the CNTs inside the aligned CNT fiber is not disrupted by the insulating behavior of ZnO nanoparticles. A high degree of control over the electrical conductivity was also demonstrated by the ZnO nanoparticles, working as electron movement bridges between CNTs in the longitudinal and crosswise directions. Well-organized surface interface chemistry was also observed, which supports the notion of CNT alignment inside the fibers. This research represents a new area of surface interface chemistry for interfacially linked CNTs and ZnO nanomaterials with improved mechanical properties and electrical conductivity within aligned CNT fibers. © 2017 American Chemical Society.

Badrul Alam M.,Atish Dipankar University of Science and Technology | Sarowar Hossain M.,Atish Dipankar University of Science and Technology | Chowdhury N.S.,Manarat International University | Ehsanul Haque Mazumder M.,University of Sydney | And 2 more authors.
Journal of Pharmacology and Toxicology | Year: 2011

In course of investigation on natural antioxidants, the present study was aimed to report the antioxidant activities, both in vitro and in vivo, of the crude methanolic extracts of the whole plant of Oxalis corniculata Linn along with its various organic fractions. The different assay methods, including total antioxidant activity, scavenging free radical, authentic peroxynitrite, nitric oxide and reducing power assessment were used to evaluate the antioxidant potential of the crude extract and its organic fractions. The ethylacetate (EtOAc) fraction, showed strong activity in all the model systems tested and in peroxynitrite model this fraction (IC50 value of 2.29±0.18 μg mL-1) exerted three-fold stronger activity than standard penicillamine (IC50 value of 6.20±0.32 μg mL-1). The reducing power of the extract was found to be concentration dependent. The administration of the extract/fractions at a dose of 250 and 500 mg kg-1 body weight to the male Wistar rats increased the percentage inhibition of reduced glutathione, superoxide dismutase and catalase significantly. Whereas, lipid peroxidation level in hepatotoxic rats markedly decreased at a dose of 500 mg kg-1 body weight after 7 days. The total phenol and flavonoid content were also measured in the crude extract along with its organic fractions. The Brine shrimp lethality bioassay was used to determine the toxicity of the extracts and Vincristin sulphate was used as positive control. The dichloromethane (CH2Cl2) fraction showed highest activity (LC50 value of 29.02±1.16 μg mL-1) and other showed activity in the order of: EtOAc fraction >n-BuOH fraction > MeOH extract > aqueous fraction. Taken together, these results suggest that O. corniculata extract has strong antioxidant properties and further validate the traditional use of this plant. © 2011 Academeic Journals Inc.

Alam M.B.,Atish Dipankar University of Science and Technology | Hossain M.S.,Atish Dipankar University of Science and Technology | Haque M.E.,Atish Dipankar University of Science and Technology
Journal of Global Pharma Technology | Year: 2010

The methanolic extract along with some organic soluble fractions of the bark of Dillenia indica Linn. were tested against four Gram-positive and seven Gram-negative bacteria and against three pathogenic fungi. N-Hexane and dichloromethane fractions showed remarkable activities against all the tested bacteria but n-Hexane fraction showed highest activity against Shigella dysenteriae and its zone of inhibition was 15.51 ± 0.75 mm. Other showed moderate or little activity. Methanol crude extract showed highest activity against fungus Candida albicans with a zone of inhibition 13.13 ± 1.75 mm. Lowest minimum inhibitory concentration (MIC) values were observed in n-Hexane fraction against Shigella dysenteriae and Staphylococcus aureus and were 0.312 in both cases. Lowest LC50 value 19.02 ± 1.16 of n-Hexane fraction indicated the highest toxicity incomparison with the other fractions. © 2009, JGPT.

Alam B.,Kyungpook National University | Alam B.,Atish Dipankar University of Science and Technology | Majumder R.,Atish Dipankar University of Science and Technology | Akter S.,Atish Dipankar University of Science and Technology | Lee S.-H.,Kyungpook National University
Oncology Letters | Year: 2015

The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells into mice, extracts were administered at 25, 50 and 100 mg/kg body weight for nine consecutive days. The antitumor effects of the extracts were then assessed according to tumor volume, packed cell count, viable and non-viable tumor cell count, median survival time and increase in life span of EAC-bearing mice. Next, hematological profiles and serum biochemical parameters were calculated, and antioxidant properties were assessed by estimating lipid peroxidation, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels. MPBL and the ethylacetate fraction (EPBL) at a dose of 100 mg/kg induced a significant decrease in tumor volume, packed cell volume and viable cell count and increased the life span of the EAC-bearing mice (P<0.05). Hematological and serum biochemical profiles were restored to normal levels in the extract-treated mice compared with the EAC control mice. MPBL and EPBL treatment significantly decreased lipid peroxidation (P<0.05) and restored GSH, SOD and CAT levels towards normal compared with the EAC control. Taken together, the results of the present study demonstrated that Piper betle extracts exhibit significant antitumor activity, which may be attributed to the augmentation of endogenous antioxidant potential. © 2015, Spandidos Publications. All rights reserved.

PubMed | Chittagong University and Atish Dipankar University of Science and Technology
Type: Journal Article | Journal: Biomedical journal | Year: 2017

Human Adenoviruses are divided into 7 species of Human Adenovirus A to G based on DNA genome homology. The Human Adenovirus E (HAdVs-E) genome is a linear, double-stranded DNA containing 38 protein-coding genes. Wild-type adenoviruses type E,are linked to a number of slight illnesses. The most important part of HAdVs-E is E3 CR1-beta protein which controls the host immune response and viral attachment.We use numerous bio-informatics and immuno-informatics implements comprising sequence and construction tools for construction of 3D model and epitope prediction for HAdVs-E.The 3D structure of E3 CR1-beta protein was generated and total of ten antigenic B cell epitopes, 6 MHC class I and 11 MHC class II binding peptides were predicted.The study was carried out to predict antigenic determinants/epitopes of the E3 CR1-beta protein of Human Adenovirus E along with the 3D protein modeling. The study revealed potential T-cell and B-cell epitopes that can raise the desired immune response against E3 CR1-beta protein and useful in developing effective vaccines against HAdVs-E.

Hossain M.M.,Yeungnam University | Shima H.,University of Rajshahi | Islam Md.A.,Atish Dipankar University of Science and Technology | Hasan M.,Yeungnam University | Lee M.,Yeungnam University
Journal of Physical Chemistry C | Year: 2016

Semiconducting ZnO was used as a surface-enhanced Raman scattering (SERS) substrate without needing to combine it with novel metal particles. An interesting synergistic effect in the Raman scattering of ZnO nanoparticles and CNTs was observed due to the vibrational force of Zn and O atoms in the Zn-O system of ZnO nanoparticles and the special deformation of CNTs in the SERS fiber. The convenient deformation of CNTs allowed a large number of carbon atoms in the planar direction, such as a graphene sheet, and facilitated the planar vibrations of sp2 carbon atoms, leading to a considerable increase in the G and 2D band intensity. A new radial breathing mode (RBM) peak was activated by the radial polarization of CNTs through the vibration force of Zn and O atoms in the Zn-O system in its radial direction. The cross-section cutting 3D image of the SERS fiber revealed the CNTs to be rearranged geometrically in the SERS fiber and formed a bunched structure because of the enhanced interactions among the individual CNTs via ZnO nanoparticles. This highlights a new dimension of research into ZnO nanomaterials and CNTs in SERS fibers and provides new insights into ZnO-CNT fiber composites. © 2016 American Chemical Society.

Islam M.R.,University of Newcastle | Khan I.,Dhaka Medical College | Hassan S.M.N.,Atish Dipankar University of Science and Technology | McEvoy M.,University of Newcastle | And 6 more authors.
Environmental Health: A Global Access Science Source | Year: 2012

Background: Chronic exposure to high level of inorganic arsenic in drinking water has been associated with Type 2 Diabetes (T2D). Most research has been ecological in nature and has focused on high levels of arsenic exposure with few studies directly measuring arsenic levels in drinking water as an index of arsenic exposure. The effect of low to moderate levels of arsenic exposure on diabetes risk is largely unknown thus our study is adding further knowledge over previous works. Methods: This cross sectional study was conducted in 1004 consenting women and men from 1682 eligible participants yielding a participation rate of 60%. These participants are aged >30 years and were living in Bangladesh and had continuously consumed arsenic-contaminated drinking water for at least 6 months. T2D cases were diagnosed using glucometer following the new diagnostic criteria (Fasting Blood Glucose > 126 mg/dl) from the WHO guideline (WHO 2006), or a self-reported physician diagnosis of type 2 diabetes. Association between T2D and chronic arsenic exposure was estimated by multiple logistic regression with adjustment for age, sex, education, Body Mass Index (BMI) and family history of T2D. Results: A total of 1004 individuals participated in the study. The prevalence of T2D was 9% (95% CI 7-11%). After adjustment for diabetes risk factors, an increased risk of type 2 diabetes was observed for arsenic exposure over 50 μg/L with those in the highest category having almost double the risk of type 2 diabetes (OR=1.9 ; 95% CI 1.1-3.5). For most levels of arsenic exposure, the risk estimates are higher with longer exposure; a doseresponse pattern was also observed. Conclusions: These findings suggest an association between chronic arsenic exposure through drinking water and T2D. Risks are generally higher with longer duration of arsenic exposure. The risk of T2D is highest among those who were exposed to the highest concentration of arsenic for more than 10 years. © 2012 Voutsadakis; licensee BioMed Central Ltd.

Zahan R.,University of Rajshahi | Nahar L.,University of Rajshahi | Nesa L.,Atish Dipankar University of Science and Technology
Pakistan Journal of Biological Sciences | Year: 2013

The present study aimed to evaluate the antinociceptive and anti-inflammatory activity of Alangium salvifolium (AS) flower in mice. The antinociceptive activity was determined using tail immerson, acetic acid induced writhing and formalin induced licking test. Antiinflammatory effects were evaluated using carrageenan and formalin induced paw edema in mice. The methanol extract (50 and 100 mg kg-1) of flower of AS followed by chloroform extract (100 mg kg-1) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mice writhing induced by acetic acid and delayed the response of mice to hot water thermal stimulation in tail immersion test. All flowers extract of AS also produced a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw edema. The inhibitions were similar to those produced by indomethacin, p.o. The different alkaloids and flavonoids found in the extract could be account for the antinociceptive and anti-inflammatory actions. © 2013 Asian Network for Scientific Information.

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