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Merzhausen, Germany

Zaburannyi N.,Helmholtz Center for Infection Research | Zaburannyi N.,German Center for Infection Research | Bunk B.,Leibniz Institute DSMZ | Bunk B.,German Center for Infection Research | And 5 more authors.
Applied and Environmental Microbiology

Here, we report the complete genome sequence of the type strain of the myxobacterial genus Chondromyces, Chondromyces crocatus Cm c5. It presents one of the largest prokaryotic genomes featuring a single circular chromosome and no plasmids. Analysis revealed an enlarged set of tRNA genes, along with reduced pressure on preferred codon usage compared to that of other bacterial genomes. The large coding capacity and the plethora of encoded secondary metabolite biosynthetic gene clusters are in line with the capability of Cm c5 to produce an arsenal of antibacterial, antifungal, and cytotoxic compounds. Known pathways of the ajudazol, chondramide, chondrochloren, crocacin, crocapeptin, and thuggacin compound families are complemented by many more natural compound biosynthetic gene clusters in the chromosome. Whole-genome comparison of the fruiting-bodyforming type strain (Cm c5, DSM 14714) to an accustomed laboratory strain which has lost this ability (nonfruiting phenotype, Cm c5 fr-) revealed genetic changes in three loci. In addition to the low synteny found with the closest sequenced representative of the same family, Sorangium cellulosum, extensive genetic information duplication and broad application of eukaryotic-type signal transduction systems are hallmarks of this 11.3-Mbp prokaryotic genome. © 2016, American Society for Microbiology. All Rights Reserved. Source

The paper reports on a study of carbon-based fullerenes C n (n = 60, 70 and 80) with the encapsulated trigonal bipyramid Co 5 cluster on the basis of the Perdew-Burke-Ernzerhof generalized gradient approximation functional (GGA-PBE) within the Density Functional Theory (DFT). It is revealed that magnetic moments of the Co 5@C n complexes depend on the fullerene size and shape, as well as orientation of Co 5 cluster in a carbon cage in the case of fullerene with D 5d point group symmetry. © 2011 Elsevier B.V. All rights reserved. Source

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