PubMed | Eskiehir Osmangazi University, Okmeydan Training and Research Hospital, Krkkale University, Yunus Emre Hospital and 2 more.
Type: | Journal: International journal of pediatric otorhinolaryngology | Year: 2016
The effect of cinnamaldehyde on the treatment of allergic rhinitis (AR) was investigated in rat model.Twenty-eight female Wistar albino rats were randomly divided into four groups: Group 1 (control) (C), Group 2 (AR with no treatment) (AR+NoTr), Group 3 (AR+Azelastine HCl) (AR+Aze), and Group 4 (AR+cinnamaldehyde) (AR+Cin). At day 21, AR+Aze rats were given an Azelastine HCl drop, and AR+Cin rats were given cinnamaldehyde intranasally. In all groups, allergic symptoms histopathological results were evaluated.The AR+NoTr group showed the worst allergic symptoms, cilia loss and greater inflammation. In the AR+Aze and AR+Cin groups, allergic symptom scores were higher than those in the control group. However, between AR+Aze and AR+Cin groups, there were no significant differences in the allergic symptom scores Histopathological analysis revealed vascular congestion and an increase in goblet cell numbers in the AR+Cin group. However, AR+Cin rat nasal mucosa had less plasma cell infiltration compared with the AR+NoTr group. In rats from the AR+Aze group, analysis of the nasal mucosa revealed less eosinophil infiltration than that seen in the AR+NoTr group. A lower score for mast cell (MC) infiltration was observed in the nasal mucosa of rats treated with Azelastine HCl compared with cinnamaldehyde.In this study we observed that both Azelastine HCl and cinnamaldehyde reduced allergic symptoms in an AR rat model. Cinnamaldehyde decreased vascular congestion as well as plasma cell, eosinophil, and inflammatory cell infiltration into the lamina propria.
Duman F.,Thomas Jefferson University |
Duman F.,Antalya Ataturk State Hospital |
Kosker M.,Thomas Jefferson University |
Kosker M.,Yozgat State Hospital |
And 8 more authors.
American Journal of Ophthalmology | Year: 2013
Purpose: To identify the most common corneal transplant procedures, indications, coexisting ocular diseases, and outcomes in elderly patients, and to compare younger geriatric patients with super-geriatric patients. Design: Retrospective case series. Methods: Data of all patients 65 years old and older who underwent corneal transplantation at Wills Eye Institute from April 2007 to January 2013, and were followed up for at least 1 year, were collected. Two hundred seventy-one eyes of 253 patients were divided into 2 groups according to the age of the patient. Results: Group I (65-79 years old) included 181 eyes and Group II (80 years and older) included 90 eyes. The most common indication was Fuchs endothelial dystrophy, with 78 eyes (43%) in Group I and 34 eyes (38%) in Group II. In Group I, 93 Descemet stripping endothelial keratoplasty (DSEK) (51%), 84 penetrating keratoplasty (PK) (46%), and 4 keratoprosthesis procedures(2%) were performed; in Group II, 37 DSEK (41%), 51 PK (57%), and 2 keratoprosthesis procedures (2%) were performed. Graft survival rate at last visit was 90% for Group I and 88% for Group II. Rejection occurred in 18 Group I eyes (10%) and 7 Group II eyes (8%) (P =.562). Conclusion: Endothelial abnormalities were more common indications and keratoconus was a less common indication for surgery in the elderly. Fuchs dystrophy was the leading indication for surgery in both super-geriatric and younger geriatric patients. Graft survival rate was slightly higher in the younger geriatric age group but was not statistically significant. In the elderly, there is an increased prevalence of both glaucoma and retinal diseases that can affect the visual outcomes after corneal transplantation. © 2013 by Elsevier Inc. All rights reserved.
PubMed | University of Art, Antalya Ataturk State Hospital, Suleyman Demirel University of Turkey, Alanya Alaaddin Keykubat University and Istanbul Science University
Type: | Journal: Human & experimental toxicology | Year: 2016
Glutathione-S-transferase (GST) and cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) metabolize and detoxify carcinogens, drugs, environmental pollutants, and reactive oxygen species. Changes of GST expression in tissues and gene mutations have been reported in association with many neoplastic skin diseases and dermatoses. Widely used artificial food coloring additives (AFCAs) also reported to effect primarily behavioral and cognitive function and cause neoplastic diseases and several inflammatory skin diseases. We aimed to identify the changes in expression of GSTs, CYP1A1, and vascular endothelial growth factor (VEGF) in rat skin which were maternally exposed AFCAs. A rat model was designed to evaluate the effects of maternal exposure of AFCAs on skin in rats. No observable adverse effect levels of commonly used AFCAs as a mixture were given to female rats before and during gestation. Immunohistochemical expression of GSTs, CYP1A1, and VEGF was evaluated in their offspring. CYP1A1, glutathione S-transferase pi (GSTP), glutathione S-transferase alpha (GSTA), glutathione S-transferase mu (GSTM), glutathione S-transferase theta (GSTT), and VEGF were expressed by epidermal keratinocytes, dermal fibroblasts, sebaceous glands, hair follicle, and subcutaneous striated muscle in the normal skin. CYP1A1, GSTA, and GSTT were expressed at all microanatomical sites of skin in varying degrees. The expressions of CYP1A1, GSTA, GSTT, and VEGF were decreased significantly, while GSTM expression on sebaceous gland and hair follicle was increased. Maternal exposure of AFCAs apparently effects expression of the CYP1A1, GSTs, and VEGF in the skin. This prominent change of expressions might play role in neoplastic and nonneoplastic skin diseases.
Ilgen Uslu F.,Antalya Ataturk State Hospital |
Ozkan M.,Antalya Yasam Hospital
Agri | Year: 2015
Painful ophthalmoplegia consists of periorbital or hemicranial pain with ipsilateral ocular motor nerve palsies. There are many etiologies of painful ophthalmoplegia. Tolosa-Hunt syndrome (THS) is an uncommon disease caused by non-specific inflammation of the cavernous sinus, superior orbital fissure and the apex of the orbit. A 45-year-old female reported episodes of reversible left eye pain and diplopia. Examination showed periorbital oedema and left palpebral semiptosis, paresis of the partial left third nerve palsy with normal pupillary reactions, fourth and sixth left cranial nerves, and hypoesthesia over the first and second division of the left trigeminal nerve. Blood analysis, postcontrast cranial and orbital magnetic resonance (MR) imaging, cranial MR angiography and CSF analysis demonstrated no abnormalities. The clinical diagnosis satisfies the criteria for THS. After steroid therapy her symptoms and clinical signs dramatically reverses. Painful ophthalmoplegia with inflammatory conditions such as THS is highly responsive to corticosteroids but should be diagnoses of exclusion. The THS diagnosis should be used rarely and with great caution. © 2015 Turkish Society of Algology.
PubMed | Antalya Yasam Hospital and Antalya Ataturk State Hospital
Type: Journal Article | Journal: Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology | Year: 2016
Painful ophthalmoplegia consists of periorbital or hemicranial pain with ipsilateral ocular motor nerve palsies. There are many etiologies of painful ophthalmoplegia. Tolosa-Hunt syndrome (THS) is an uncommon disease caused by non-specific inflammation of the cavernous sinus, superior orbital fissure and the apex of the orbit. A 45-year-old female reported episodes of reversible left eye pain and diplopia. Examination showed periorbital oedema and left palpebral semiptosis, paresis of the partial left third nerve palsy with normal pupillary reactions, fourth and sixth left cranial nerves, and hypoesthesia over the first and second division of the left trigeminal nerve. Blood analysis, postcontrast cranial and orbital magnetic resonance (MR) imaging, cranial MR angiography and CSF analysis demonstrated no abnormalities. The clinical diagnosis satisfies the criteria for THS. After steroid therapy her symptoms and clinical signs dramatically reverses. Painful ophthalmoplegia with inflammatory conditions such as THS is highly responsive to corticosteroids but should be diagnoses of exclusion. The THS diagnosis should be used rarely and with great caution.
Akcal M.A.,Antalya Ataturk State Hospital |
Poyanli O.,Istanbul Medeniyet University |
Unay K.,Istanbul Medeniyet University |
Esenkaya I.,Istanbul Medeniyet University |
And 2 more authors.
Journal of Orthopaedic Surgery and Research | Year: 2014
Background: Comminuted fractures can occur due to severe traumas. The treatment of these fractures that may cause serious morbidity and sometimes mortality is N-butyl cyanoacrylate. It has been reported that this adhesive provides sufficient rigid fixation for bone healing. This study aims to examine cyanoacrylate radiologically and histologically to determine whether it provides adequate recovery in segmental fractures. The secondary objective is to evaluate N-butyl cyanoacrylate, an adhesive material that can hold the fragments on the fracture line together following reduction.Methods: Sixteen Sprague-Dawley rats were divided in two groups as control (n = 8) and experimental (n = 8) groups. In the control group, segmental fractures were made and fixated with K-wire. In the experimental group, the same surgical procedure was applied and also fragments were stabilized with N-butyl cyanoacrylate.Results: On the sixth week, we did not see any statistically significant difference in the radiological scoring between groups. However, the pathological scores of the control group were statistically higher than the cyanoacrylate group.Conclusions: We found that cyanoacrylate was rapidly and easily applied in the segmental fractures but did not cause any superior radiological and clinical results compared to the control group. The cyanoacrylate had low viscosity, and it was not capable enough to fill the defects formed between osteotomy surfaces. However, it did not adversely affect fracture healing as seen in biopsies taken as a result of follow-ups. © 2014 Akcal et al.; licensee BioMed Central Ltd.
Cetinkaya E.A.,Antalya Ataturk State Hospital |
Arslan T.B.,Izmir Tepecik Training Research Hospital |
Cukurova I.,Izmir Tepecik Training Research Hospital
International Journal of Pediatric Otorhinolaryngology | Year: 2015
Objectives: To evaluate 1875 cases of nasal foreign body (NFB) removal with regard to type of foreign body (FB), location, complications, techniques for removal, age and gender, and to present the results of the evaluation. Methods: Between 2006 and 2013, a total of 1875 NFBs were removed from 1870 children in ENT Services of Antalya Ataturk State Hospital and Izmir Tepecik Training - Research Hospital. A retrospective review was undertaken to evaluate the parameters related to the NFBs and their removal and the data were analyzed. Results: The most frequent NFBs were hard spherical objects and the most common locations to lodge were on the right side just anterior to the middle turbinate. Prolonged exposure increases the complication rate, and button batteries are particularly ominous as they drift into the airway, never observed. We found a higher incidence in patients between ages 2 and 5 years. The distribution of NFBs was 52.9% in boys and 47.1% in girls. Conclusions: NFBs are most commonly hard, round objects. Button batteries and penetrating FBs must be treated immediately. Complications from NFBs are rare but may be potentially serious or even life threatening. © 2015 Elsevier Ireland Ltd.
Alan S.,Akdeniz University |
Canan F.,Akdeniz University |
Karakas A.A.,Akdeniz University |
Gecici N.,Antalya Ataturk State Hospital
Postepy Dermatologii i Alergologii | Year: 2015
Introduction: Psychosocial factors have been implicated as being important in the onset and/or exacerbation of urticaria. Aim: To examine both personality factors of patients with chronic idiopathic urticaria (CIU) and the correlations between illness duration, severity of itching, urticaria activity score (UAS) and temperament-character dimensions. Material and methods: A total number of 70 CIU patients and 60 healthy individuals were included in the study. The Temperament and Character Inventory (TCI) was administered individually. The relationship between UAS, illness duration and severity of pruritus and TCI subscales were evaluated. Results: The CIU group had significantly higher scores of novelty seeking and lower scores of cooperativeness, reward dependence and self-directedness than the control group. Conclusions: The current study shows that CIU patients have distinctive temperament and character dimensions when compared with the control group. We suggest that evaluation and treatment of CIU should also include psychosomatic approaches in clinical practice.
Bas B.O.,Antalya Ataturk State Hospital
Studies on Ethno-Medicine | Year: 2016
The purpose of this study is to conduct applied research through evaluation of individuals with a constipation problem due to various reasons in terms of their socio-demographic characteristics. The research population is from Turkey, while its sample consists of men and women living in different city centers of Marmara, Black Sea, Central Anatolia, Eastern Anatolia, Mediterranean and Southeastern Anatolia regions. The research took approximately 5 months. During the period of this research, (n=2007) men and (n=1853) women participated in the research. The respondents were administered a questionnaire consisting of two sections. The first section includes 32 questions about socio-demographic characteristics of the respondents, while the second section contains 28 questions as a 5-point Likert scale. The SPSS 18 statistical program was used during this study conducted for patients with varying professional, educational, income and socio-demographic features. The data obtained was entered into this program and put to a reliability test. This test resulted in Cronbach’s Alpha coefficient of 0.891. This number obtained from the test shows that the measuring device utilized in this research is highly reliable. While different analysis techniques were employed for analyzing the results, the multiple regression, ANOVA, chisquare, factor, hypothesis and variance analyses were applied. Upon analyses and questionnaire, it is seen that many respondents have a problem of constipation and psychological, eating and drinking habits, family, gender and other different factors are effective in terms of constipation problem. © Kamla-Raj 2016.
PubMed | Antalya Ataturk State Hospital
Type: Journal Article | Journal: European review for medical and pharmacological sciences | Year: 2016
Cardiovascular diseases (CVD) are common in patients with chronic obstructive pulmonary disease (COPD) and the BODE index is an important tool for the prognostic assessment of COPD patients. It is well known that epicardial fat thickness (EFT) is related to CVD. However, there are very few data about the relationship between EFT and BODE index. The aim of this study is to investigate the relationship between EFT and BODE index in patients with COPD.We prospectively included 157 patients with COPD and 45 controls in the present study. All patients underwent pulmonary function tests and six-minute walking test. EFT and other echocardiographic parameters were measured using transthoracic echocardiography on admission. Patients were divided into four quartiles according to the BODE index scores (Quartile-1 (Q1): 0-2 points; Quartile-2 (Q2): 3-4 points; Quartile-3 (Q3): 5-6 points; Quartile-4 (Q4): 7-10 points). High sensitive C-reactive protein (Hs-CRP) and other biochemical parameters were measured in all participants.COPD patients had higher EFT values compared with control group (p<0.05). When COPD patients were classified according to BODE index quartiles, the highest EFT values were observed in Q1 compared with other quartiles (p<0.05, for all). EFT values showed a decreasing trend from Q1 to Q4. Furthermore, EFT was independently associated with BODE index (=0.405, p<0.001), Hs-CRP (=0.300, p<0.001) and diabetes (=0.338, p<0.001) in multivariate linear regression analysis.Our findings suggested that EFT is independently and negatively associated with the severity of disease as indicated by BODE index in patients with COPD.