Ataturk Chest Disease and Chest Surgery Training and Research Hospital

Ankara, Turkey

Ataturk Chest Disease and Chest Surgery Training and Research Hospital

Ankara, Turkey
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Yilmaz A.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Demirci N.Y.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Hosgun D.,Agri Public Hospital | Uner E.,Numune Education and Research Hospital | And 3 more authors.
World Journal of Gastroenterology | Year: 2010

AIM: To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease (IBD). METHODS: Thirty ulcerative colitis (UC) and nine Crohn's disease patients, and 20 control subjects were enrolled in this prospective study. Detailed clinical information was obtained. Extent and activity of the bowel disease were established endoscopically. Each patient underwent pulmonary function tests and high-resolution computed tomography (HRCT). Blood samples for measurement of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), angiotensin converting enzyme and total IgE were delivered by the patients. RESULTS: Ten (25.6%) patients had respiratory symp toms. A pulmonary function abnormality was present in 22 of 39 patients. Among all patients, the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) 25%-75%, transfer coefficient for carbon monoxide (DLCO), DLCO/alveolar volume. Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients. Endoscopic and clinical activities in UC patients were correlated with FEV1, FEV1/FVC, and FEF 25%-75%. Smoking status, duration of disease and medication were not correlated with pulmonary physiological test results, HRCT abnormalities, clinical/endoscopic disease activity, CRP, ESR or total IgE level or body mass index. CONCLUSION: It is important that respiratory manifestations are recognized and treated early in IBD. Otherwise, they can lead to destructive and irreversible changes in the airway wall. © 2010 Baishideng.


Yildiz F.,Kocaeli University | Oguzulgen I.K.,Gazi University | Dursun B.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Mungan D.,Ankara University | And 2 more authors.
Tuberkuloz ve Toraks | Year: 2011

Asthma still has high morbidity and cost despite all advances in pathogenesis, diagnosis and treatment. Although asthma can be controlled with proper diagnosis and treatment, the low rates of control in our country and in the world can not be attributed to the variable course of the disease and patients' psycho-social behaviours for chronic disease. In this context, Turkish Thoracic Society (TTS) has decided to update Asthma Diagnosis and Management Guide latest published in 2000. National data were collected, compiled and prepared by authors, and final form given by the TTS Asthma and Allergy Study Group, after presenting to consultant individuals and institutions. In June 2009, the National Asthma Management and Prevention Guideline were published in Turkish. In this paper, we aimed to present the national guide in English with its basics and individual differences.


Findik G.,Ataturk Chest Diseases and Chest Surgery Training and Research Hospital | Gezer S.,Duzce University | Aydogdu K.,Ataturk Chest Diseases and Chest Surgery Training and Research Hospital | Oz G.,Ataturk Chest Diseases and Chest Surgery Training and Research Hospital | And 4 more authors.
Thoracic and Cardiovascular Surgeon | Year: 2010

Objective: Povidone-iodine (PI) is an effective disinfectant used in many surgical operations. It is known that PI is absorbed by the skin after application. Absorption is even greater in infants, as their skin is thinner and more permeable. Iodine absorption in the orbita, neck and during abdominal surgery has been previously investigated, but such a study has not been performed for the pleura, which has a greater area and capacity for absorption. In this study, we investigated the effect of intraoperative povidone-iodine lavage on thyroid hormones during thoracic surgery. Material and Method: Fifty patients without any thyroid pathology scheduled for thoracotomy were divided into 2 groups. Group A (n=25) was given intraoperative saline lavage, while group B (n=25) had povidone-iodine lavage. Levels of free T3 (FT3), free T4 (FT4) and thyroid-stimulating hormone (TSH) measured 1 day preoperatively and 1 day postoperatively were analyzed. Results: There was a statistically meaningful change in FT3 levels (p=0.033) between groups, but the measured changes in FT4 and TSH levels were not statistically significant (p=0.98 and p=0.71, respectively). FT3 scores for group A were decreased postoperatively compared to the scores for group B, but all results were in normal ranges. In group A, the changes between preoperative and postoperative levels of FT3 and FT4 were statistically significant, while changes in TSH levels were not. In group B, changes in FT4 levels were statistically significant and changes in FT3 and TSH levels were not. Conclusions: The scores show that the iodine absorbed by the pleura during intraoperative povidone-iodine lavage has an effect on thyroid function. Intrapleural PI lavage results in changes to some thyroid hormone levels due to pleural absorption. Thus, intrapleural PI lavage should be used with care. © Georg Thieme Verlag KG Stuttgart.


Gunbey E.,Ondokuz Mayis University | Acar B.,Kecioren Training and Research Hospital | Tuncay K.S.,Halil Sivgin Cubuk State Hospital | Guven S.F.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Karasen R.M.,Gazi University
Acta Medica Mediterranea | Year: 2015

Objective: To assess the influence of upper airway sensory dysfunction on the respiratory events during sleep in patients with obstructive sleep apnea syndrome (OSAS). Methods: Our study was performed over 30 patients with OSAS. The patients underwent a second night polisomnography (PSG) after bupivacaine application to uvula and soft palate and the outcomes of both PSG results were compared. Results: In PSG-2, the mean Apnea-hypopnea index (AHI), AHI-supine, AHI-right lateral, AHI-REM and AHI-nonREM values were significantly higher than the same data acquired in PSG-1 (p<0.001, p=0.001, p<0.001, p<0.001, and p=0.001, respectively). In PSG-2, mean and minimum arterial O2 saturation were significantly lower compared to PSG-1 (p=0.021 and p=0.039, respectively). The correlation analysis of PSG-2 showed that AHI-nonREM and AHI-supine are more effected from the sensorial blockade. Conclusion: Our study showed that, when the protective neuromuscular mechanism is removed by upper airway sensory blockage, the severity of OSAS increases. Upper airway sensorial blockade more influentially effects respiratory events in supine position and in non-REM phase.


Turkoz F.P.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Solak M.,Hacettepe University | Kilickap S.,Hacettepe University | Ulas A.,Ankara Ataturk Training and Research Hospital | And 3 more authors.
Journal of Gastric Cancer | Year: 2014

Results: The incidence of bone metastasis was 3.8%. The most common histopathological subtype was adenocarcinoma (79%) with poor differentiation (60.8%). The median interval from the diagnosis to bone metastasis was 11 months. The median survival time after bone metastasis was 5.4 months. Factors that were associated with longer median survival times included the following: isolated bone metastasis (P=0.004), well-differentiated tumors (P=0.002), palliative chemotherapy (P=0.003), zoledronic acid treatment (P<0.001), no smoking history (P=0.007), and no metastatic gastric cancer at the time of diagnosis (P=0.01). On the other hand, high levels of lactate dehydrogenase (LDH) (hazard ratio [HR]: 1.86; P=0.015), carcinoembryonic antigen (CEA) (HR: 2.04; P=0.002), and carbohydrate antigen (CA) 19-9 (HR: 2.94; P<0.001) were associated with shorter survival times. In multivariate analysis, receiving zoledronic acid (P<0.001) and performance status (P=0.013) were independent prognostic factors.Purpose: To evaluate the incidence, clinicopathological characteristics, treatment outcomes, prognostic factors, and survival of gastric cancer patients with bone metastases.Materials and Methods: Of 4,617 gastric cancer patients who were treated between 2001 and 2013, 176 patients with bone metastases were analyzed.Conclusions: Smoking history, poor performance status, poorly differentiated adenocarcinoma, and high levels of LDH, CEA, and CA 19-9 were shown to be poor prognostic factors, while receiving chemotherapy and zoledronic acid were associated with prolonged survival in gastric cancer patients with bone metastases. © 2014 by The Korean Gastric Cancer Association.


PubMed | Ataturk Chest Disease and Chest Surgery Training and Research Hospital, Ankara Ataturk Training and Research Hospital, Dr Abdurrahman Yurtaslan Ankara Oncology Training And Research Hospital and Hacettepe University
Type: Journal Article | Journal: Journal of gastric cancer | Year: 2014

To evaluate the incidence, clinicopathological characteristics, treatment outcomes, prognostic factors, and survival of gastric cancer patients with bone metastases.Of 4,617 gastric cancer patients who were treated between 2001 and 2013, 176 patients with bone metastases were analyzed.The incidence of bone metastasis was 3.8%. The most common histopathological subtype was adenocarcinoma (79%) with poor differentiation (60.8%). The median interval from the diagnosis to bone metastasis was 11 months. The median survival time after bone metastasis was 5.4 months. Factors that were associated with longer median survival times included the following: isolated bone metastasis (P=0.004), well-differentiated tumors (P=0.002), palliative chemotherapy (P=0.003), zoledronic acid treatment (P<0.001), no smoking history (P=0.007), and no metastatic gastric cancer at the time of diagnosis (P=0.01). On the other hand, high levels of lactate dehydrogenase (LDH) (hazard ratio [HR]: 1.86; P=0.015), carcinoembryonic antigen (CEA) (HR: 2.04; P=0.002), and carbohydrate antigen (CA) 19-9 (HR: 2.94; P<0.001) were associated with shorter survival times. In multivariate analysis, receiving zoledronic acid (P<0.001) and performance status (P=0.013) were independent prognostic factors.Smoking history, poor performance status, poorly differentiated adenocarcinoma, and high levels of LDH, CEA, and CA 19-9 were shown to be poor prognostic factors, while receiving chemotherapy and zoledronic acid were associated with prolonged survival in gastric cancer patients with bone metastases.


Demirci N.Y.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Turay U.Y.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Yilmaz A.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Erdogan Y.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2011

Background and aims: In lung cancer, many factors have prognostic significance, including thrombocytosis, which is frequently observed. Associations between vascular events, which are the outcomes of paraneoplastic symptoms, and mortality and morbidity has been evaluated in many studies. The aim of the present study was to evaluate the relationship between thrombocytosis and vascular events. Materials and Methods: In total, 281 patients, who were histopathologically diagnosed with lung cancer between March 2007 and August 2009, were evaluated retrospectively. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) software (ver. 11.5 for Windows). Analysis of the distribution of constant variance for normality was assessed using the Shapiro-Wilk test. Nominal variables were evaluated using Pearson's chi-squared or Fisher's exact chi-squared tests. Significant correlations between continuous variables were investigated using Spearman's correlation test. Results: Of the 281 patients, 234 (83.3%) were males and 47 (16.7%) were females, with a median age of 60.6 (31-83 years). Histopathologically, 40 (14.2%) were diagnosed with small-cell lung cancer and 241 (85.8%) with non-small cell lung cancer. In total, 17 (6.04%) vascular events were identified: 11 (64.7%) deep vein thromboses, three (17.6%) pulmonary thromboembolisms, one (5.9%) cerebral arterial thrombosis, and one (5.9%) vena cava superior thrombosis. Thrombocytosis was not determined during thrombosis, but during subsequent visits. Conclusions: Thrombocytosis is frequently observed in patients with lung cancer. Further prospective studies are required to evaluate the need for prophylactic anticoagulants in these patients. The association between vascular events and survival, the next step of the present study, will be evaluated prospectively.


Babademez M.A.,Kecioren Training and Research Hospital | Ciftci B.,Ataturk Chest Disease and Chest Surgery Training and Research Hospital | Acar B.,Kecioren Training and Research Hospital | Yurekli M.F.,Kecioren Training and Research Hospital | And 3 more authors.
ORL | Year: 2010

Objective: To assess the effectiveness of low-temperature bipolar radiofrequency ablation for Coblation of the tongue base in the multilevel management of supine-position-associated obstructive sleep apnea syndrome (OSAS). Study Design and Setting: A retrospective analysis of the data of 16 subjects undergoing uvulopalatopharyngoplasty and tongue base Coblation. The efficacy of the procedure was investigated on the basis of polysomnographic results. Results: The success rate was 62.5% in 16 patients who underwent surgery for OSAS, with decreases in the mean Apnea Hypopnea Index of 20.1-8.9. The success rate was separately evaluated according to the subjects' posture. A rate of 87.5% was found for the supine position, while the rate was 56.6% in non-supine positions. The minimum postoperative O2 saturation was significantly increased for REM and non-REM stage 3 sleep rates. Conclusion: It is important to evaluate the relation of the disease to the body position in sleep apnea subjects. Coblation of the tongue base is an applicable method of therapy for patients who have sleep apnea that is more marked in the supine position. © 2010 S. Karger AG.


PubMed | Ataturk Chest Disease and Chest Surgery Training and Research Hospital
Type: Journal Article | Journal: World journal of gastroenterology | Year: 2010

To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease (IBD).Thirty ulcerative colitis (UC) and nine Crohns disease patients, and 20 control subjects were enrolled in this prospective study. Detailed clinical information was obtained. Extent and activity of the bowel disease were established endoscopically. Each patient underwent pulmonary function tests and high-resolution computed tomography (HRCT). Blood samples for measurement of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), angiotensin converting enzyme and total IgE were delivered by the patients.Ten (25.6%) patients had respiratory symptoms. A pulmonary function abnormality was present in 22 of 39 patients. Among all patients, the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) 25%-75%, transfer coefficient for carbon monoxide (DLCO), DLCO/alveolar volume. Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients. Endoscopic and clinical activities in UC patients were correlated with FEV1, FEV1/FVC, and FEF 25%-75%. Smoking status, duration of disease and medication were not correlated with pulmonary physiological test results, HRCT abnormalities, clinical/endoscopic disease activity, CRP, ESR or total IgE level or body mass index.It is important that respiratory manifestations are recognized and treated early in IBD. Otherwise, they can lead to destructive and irreversible changes in the airway wall.


PubMed | Ataturk Chest Disease and Chest Surgery Training and Research Hospital
Type: Journal Article | Journal: Inflammation | Year: 2015

Interleukin 8 (IL-8) is used to evaluate the severity of inflammation in the airways. The aim of this study was to evaluate patients with chronic obstructive pulmonary disease (COPD) for the presence of upper respiratory tract involvement by questioning patients regarding nasal symptoms and by measuring levels of IL-8 in nasal lavage material. A total of 47 COPD patients and 23 healthy controls were enrolled in this study. Pulmonary function tests were performed for all participants who were asked to complete a Sinonasal Outcome Test-20 (SNOT-20) questionnaire on the same day, as a measure of quality of life. Median IL-8 level in nasal lavage specimens of COPD patients with stable disease was higher than that of healthy controls. An increase in cigarette pack-years was significantly associated with an increase in nasal IL-8 levels. Similarly, IL-8 levels correlated positively with stage of COPD. A significant link between number of visits to the emergency department and stage of disease was observed. Patients with COPD had a significantly higher mean SNOT-20 severity score compared to healthy controls. Proper management of sinonasal disease may help to decrease the number of COPD attacks and consequently improve quality of life.

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