Gage J.R.,Asymchem Inc. |
Guo X.,Asymchem Life Science Tianjin Co. |
Tao J.,Asymchem Life Science Tianjin Co. |
Zheng C.,Asymchem Inc.
Organic Process Research and Development | Year: 2012
The design and use of a flow reactor for scaling up an exothermic nitration reaction in a safe manner on production scale is described. The flow reactor is made of a jacketed, stainless steel coil. Two charging methods, pump and nitrogen pressure were tested on a substituted pyridine substrate. The transfer from kilogram scale in the laboratory to 100-kg scale in the plant was successfully accomplished. © 2012 American Chemical Society.
Frantz M.-C.,University of Pittsburgh |
Pierce J.G.,University of Pittsburgh |
Pierce J.M.,University of Pittsburgh |
Kangying L.,Asymchem Inc. |
And 3 more authors.
Organic Letters | Year: 2011
Chemical equations presented. JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation- transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furthermore, this versatile methodology allows for the synthesis of cyclopropyl and fluorinated analogs of the parent lead structure. © 2011 American Chemical Society.