D'Andrea G.,Research and Innovation RandI S.r.l. |
D'Amico D.,C Besta Neurological Institute Irccs Foundation |
Bussone G.,C Besta Neurological Institute Irccs Foundation |
Bolner A.,Research and Innovation RandI S.r.l. |
And 8 more authors.
Cephalalgia | Year: 2013
Objective: The pathogenesis of chronic migraine (CM) remains largely unknown. We hypothesized that anomalies of tyrosine metabolism, found in migraine without aura (MwwA) patients, play an important role in the transformation of MwwA into CM, since the increase in the number of MwwA attacks is the most predisposing factor for the occurrence of CM. Methods: To test our hypothesis we measured the plasma levels of dopamine (DA), noradrenaline (NE) and trace amines, including tyramine (TYR) and octopamine (OCT), in a group of 73 patients with CM, 13 patients with chronic tensiontype headache (CTTH) and 37 controls followed in the Headache Centers of the Neurology Departments of Asti, Milan and Vicenza hospitals in Italy. Results: The plasma levels of DA and NE were several-fold higher in CM patients compared with control subjects (p>0.001). The plasma levels of TYR were also extremely elevated (p>0.001); furthermore, these levels progressively increased with the duration of the CM. Conclusions: Our data support the hypothesis that altered tyrosine metabolism plays an important role in the pathogenesis of CM. The high plasma levels of TYR, a potent agonist of the trace amine associated receptors type 1 (TAAR1), may ultimately down-regulate this receptor because of loss of inhibitory presynaptic regulation, therein resulting in uncontrolled neurotransmitter release. This may produce functional metabolic consequences in the synaptic clefts of the pain matrix implicated in CM. © 2013 International Headache Society.
D'Amico D.,Neurological Institute IRCCS Foundation |
Bussone G.,Neurological Institute IRCCS Foundation |
Aguggia M.,Asti Hospital |
Saracco M.G.,Asti Hospital |
And 3 more authors.
Neurological Sciences | Year: 2014
The primary aim of this study (TA-CH, Tryptophan Amine in Chronic Headache) was to investigate a possible role of tryptophan (TRP) metabolism in chronic migraine (CM) and chronic tension-type headache (CTTH). It is not known if TRP metabolism plays any role in CM and/or CTTH. Plasma levels of serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), metabolite of 5-HT, and tryptamine (TRY) were tested in 73 patients with CM, 15 patients with CTTH and 37 control subjects. Of these, plasmatic TRY was significantly lower in CM (p < 0.001) and in CTTH (p < 0.002) patients with respect to control subjects, while 5-HIAA levels in plasma were within the same range in all groups. 5-HT was undetectable in the plasma of almost all subjects. Our results support the hypothesis that TRP metabolism is altered in CM and CTTH patients, leading to a reduction in plasma TRY. As TRY modulates the function of pain matrix serotonergic system, this may affect modulation of incoming nociceptive inputs from the trigeminal endings and posterior horns of the spinal cord. We suggest that these biochemical abnormalities play a role in the chronicity of CM and CTTH. © 2014, Springer-Verlag Italia.
Tonini M.C.,G Salvini Hospital |
Tonini M.C.,G Salvini Hospital Garbagnate Mse Mi |
Giordano L.,Mario Negri Institute for Pharmacological Research |
Atzeni L.,San Gerardo Hospital |
And 28 more authors.
Epilepsy and Behavior | Year: 2012
The prevalence and characteristics of interictal headache, epilepsy and headache/epilepsy comorbidity were assessed in 858 women and 309 men aged 18-81. years from headache and epilepsy centers in Italy. The research hypothesis was that comorbidity among patients with either disorder would be expected to be higher than in the general population.Interictal headache was diagnosed in 675 cases (migraine 482; tension-type headache 168; other types 25), epilepsy in 336 (partial 171; generalized 165) and comorbidity in 156 (1.6% from headache centers; 30.0% from epilepsy centers). Patients with epilepsy, headache and comorbidity differed in a number of demographic and clinical aspects. However, for both headache and epilepsy, a family history of the same clinical condition was equally prevalent in patients with and without comorbidity. These findings do not support the purported association between headache and epilepsy. © 2012 Elsevier Inc.
Zicari G.,Chieri Hospital |
Marro S.,Chieri Hospital |
Panata M.,Chieri Hospital |
Soardo V.,Asti Hospital |
And 5 more authors.
Progress in Nutrition | Year: 2014
Background: The Italian national regulations, to verify the suitability of water intended for human consumption, require the monitoring of a concentration of about 70 chemical, physical and microbiological parameters. In Piedmont, where 4,357,663 residents are divided into 1,207 municipalities (2012), analytical monitoring is implemented by 12 local health authorities in collaboration with the laboratories of the Regional Agency for Environmental Protection. Objectives: We present the results of monitoring the quality of water intended for human consumption implemented by the Health Service and other information provided by the Managers of the water service. Methods: The official results of the analytical control of water intended for human consumption are recorded in Regional Health Service databases. These databases also collect information on the managers of the water service and the characteristics of the distribution network. Results: Most of the 2,222 water networks in Piedmont can serve up to 500 people and less than 40 networks could provide a sufficient quantity of water to meet all regional households demands. The Local Health Authorities make at least 21,000 samples of water per year, by some of the 8,478 sites selected for sampling, mainly in the terminal part of the distribution network. In the years 2008-2012, it have been implemented 790,306 analytical determinations about 74 different parameters, including 23 residues of plant protection products. The highest fraction of non-compliant parameters, taken over by some local health authorities, was equal to 2% of the researches which were carried out. Among the parameters that do not comply, it should be noted: coliform bacteria at 37°C, Clostridium perfringens, Escherichia coli, aluminum, arsenic, iron, manganese, nitrates and sulfates; atrazine, bentazone, desethylatrazine, metolachlor and terbuthylazine. Conclusions and recommendations: The management of the analytical control officer provides annual regional planning that could be improved by making it more flexible and adaptable to different local contexts. © Mattioli 1885
PubMed | Health service consultant and corresponding author., Asti Hospital and Chieri Hospital
Type: Journal Article | Journal: Igiene e sanita pubblica | Year: 2014
Italian legislation (Article 13 of Legislative Decree 31/2001) provides for the possibility of establishing derogations from chemical parametric values for drinking water set by EU legislation (Council Directive 98/83/EC), if the supply of drinking water cannot be maintained by any other reasonable means. A derogation is possible only after obtaining a specific authorization and must be limited to the shortest time possible. This paper presents the history of derogations granted in Italy and the case of arsenic and nickel in Piedmont. From 2003 to 2009, 13 regions requested a derogation (Campania, Emilia Romagna, Latium, Lombardy, Marche, Piedmont, Apulia, Sardinia, Sicily, Tuscany, Trentino Alto Adige, Umbria, Venetia) at different times and for a total of 13 parameters. In 2012, tap water provided to almost one million Italians in 112 municipalities of three regions (Latium, Tuscany and Campania), did not comply with the legal limits for the following parameters: arsenic, boron and fluorides. Currently, in the Piedmont region there are no derogations from the maximum permitted concentrations of contaminants in drinking water. In the past derogations have been applied for the nickel parameter (years 2006-2007) and from the arsenic parameter (years 2006-2008).
Soardo V.,Asti Hospital |
Rivetti D.,Asti Hospital
Progress in Nutrition | Year: 2013
The agronomic spreading of livestock manure is almost exclusively carried out considering the nitrogen and a few other crop nutrients such as phosphorus and potassium. The contaminants that can be found in manure are different: pathogens, drug residues, heavy metals such as copper and zinc. These could lead to contamination of water, soil and food. In some areas, due to the presence of farms, the probability of increasing the risks to health and the environment increase.The contribution of manure, such as to distribute the maximum amount of nitrogen fixed by the regulations, may result in increased concentrations of unwanted substances at levels higher than those naturally present in soil and water. It is estimated that in Piedmont, for every 10,000 square meters of agricultural land, we have the availability of manure derived from 2 cows, 3 pigs, 22 chickens and 700 kg of compost from municipal solid waste and up to 200 kg of sludge from wastewater treatment. Still to be added chemical fertilizers and digested by anaerobic fermentation also using the dedicated crops such as corn. In this paper we examine some risks of chemical and preventive measures are proposed.
Tariff modulation for the access to the drinking water system as strategies to the water resource safeguard in the Province of Asti (Italy) [La modulazione della Tariffa per laccesso al servizio di distribuzione delle acque potabili quale strategia per salvaguardare la risorsa idrica, in Provincia di Asti]
Soardo V.,Asti Hospital |
Berruti R.,Asti Hospital |
Panata M.,Asti Hospital |
Cerrato E.,Asti Hospital
Progress in Nutrition | Year: 2014
The term "Fare" indicates the payment rate that users must implement to use the service water supply. The Price for drinking water supply distinguishes between a domestic use and other types of use, such as the agricultural or the industrial one, and it is given by the sum of a fixed quota and another proportional to consumption. Method: We compared the fares of different categories of users applied by the Managers of the Water Service operating in the Province of Asti area (Piedmont, Italy), where 222,500 inhabitants live. Results: In the Province of Asti, over 13 Managers of Water Service are active to supply more than 100 water networks and in various municipalities very different prices have been applied: they can vary up to 3-4 times. Generally, the prices applied to households are more than the double of those applied to agricultural and livestock utilities, but at least 80-90 times lower than bottled water prices. In this paper, we examine the prices applied by the different municipalities in the Province of Asti and we propose strategies to modulate the costs on the basis of "efficiency and sustainability" in order to encourage savings and a better use of water resources.