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Astana, Kazakhstan

Sinyavsky Y.A.,Kazakh Academy of Nutrition | Tsoy N.O.,Astana Medical University
Voprosy Pitaniia | Year: 2014

Currently, one of discussed questions of acne etiopathogenesis is alimentary factors, in particular, national dietary habits at different regions and the role of diet. The purpose of this research: from the standpoint of evidence-based medicine to reveal the influence of dietary intake (energy value of the diet, macro-and micronutrients content) on the actual severity of acne in young people. We observed 180 respondents aged 15 to 25 years. The main group included 90 patients with moderate to severe acne, who were treated at the Center for Dermatology and prevention of sexually transmitted diseases in Astana, including 38 girls and 52 boys, mean age 20,5±4,3 years. The control group consisted of 90 apparently healthy subjects (36 girls and 54 boys, mean age 19,8±4,2 years) without even a single manifestation of non-inflammatory or inflammatory acne elements. Studying the actual food consumption was carried out by a 24-hour (daily) food recall using specially designed questionnaires and albums. Results: regular meals with excess energy value significantly contributes to the progression of disease severity in young people with acne [the power of influence in young men was 0,43 (43%), girls - 0,42 (42%)], the excess of the normal daily requirements for carbohydrates also significantly affect the severity of acne [the power of influence in young men -0,23 (23%), in girls - 0,35 (35%)], lack of vitamin A (retinol) and its provitamin (carotene) significantly affect the severity of acne (the power of influence in young men - 0,44 (44%) and 0,42 (42%), respectively, in girls - 0,46 (46%) and 0,31 (31%), respectively); in young men with severe acne vitamin D deficiency with a force of 0,3 (30%) significantly potentiates the inflammatory process; lack of zinc in the diet significantly affects the severity of the pathological process in severe forms of acne, the power of influence of this micronutrient in young men - 0,44 (44%), women - 0,34 (34%). Source


Ospanov O.B.,Astana Medical University
Obesity Surgery | Year: 2016

Background: This video demonstrates laparoscopic band-separated one anastomosis gastric bypass—combining the advantages of banding and gastric bypass without stapler and cutter use. This is basically a gastrojejunal loop bypass above an obstructive band in the upper stomach. Materials and Surgical Technique: An adjustable low pressure “Medsil” gastric band was introduced in the abdomen and retracted through the retrogastric tunnel. The front wall of the stomach below the band was displaced in the upward direction through the ring band, increasing the size of the anterior portion of the stomach pouch so that a gastroenteroanastomosis could be created at this point. Gastro-gastric sutures were placed to create a gastro-gastric plication around the band and hold it in position. The band tubing was exteriorized and connected to a special port, which was secured to the abdominal wall fascia. A jejunal loop was created about 200 cm from the ligament of Treitz and anastomosed to the gastric pouch by hand using Vicryl 2/0 sutures. Results: Between November 2015 and February 2016, the study was performed on 10 patients. The average operating time for all cases was 75 min (range 63–87). There was no morbidity or mortality. No complications were observed, including band erosion and band infection. Operation costs were about $2000 lower with this method than with standard gastric bypass surgery. Postop the patients lost weight by 3–4 kg per month. Conclusion: Preliminary results show that laparoscopic band-separated one anastomosis gastric bypass have feasibility, safety, efficacy, and reduced operating costs. © 2016 Springer Science+Business Media New York Source


Dehaen W.,Catholic University of Leuven | Mashentseva A.A.,Catholic University of Leuven | Mashentseva A.A.,Eurasian University | Seitembetov T.S.,Astana Medical University
Molecules | Year: 2011

This review covers the chemistry of allobetulin analogs, including their formation by rearrangement from betulin derivatives, their further derivatisation, their fusion with heterocyclic rings, and any further rearrangements of allobetulin compounds including ring opening, ring contraction and ring expansion reactions. In the last part, the most important biological activities of allobetulin derivatives are listed. One hundred and fifteen references are cited and the relevant literature is covered, starting in 1922 up to the end of 2010. © 2011. Source


Tsoy N.,Astana Medical University
World Journal of Medical Sciences | Year: 2013

According to data of foreign authors, the risk of development and severity of course of acne may be aggravated by the consumption of milk and dairy products, high-carbon or rich in hidden fats diet etc. The purpose of this study is to detect the influence of national eating preferences upon the development of acne of young people and to identify the pathogenetic importance of milk and dairy products for such patients. A case-control study was conducted with the participation of 523 students. Respondents were offered to fill in specially developed questionnaires-inquirers for establishing the dietary habits of the students or their eating preferences such as frequency of consumption of milk and dairy products, high-carbon food, chocolate, carbonated beverages. It was detected that the high-carbon diet increases the risk of acne occurrence; consumption of high-carbon food in the group of persons with skin pathology made up 67.7%, while in the group without acne it was 32.6%. Among the persons with the highest level of consumption of milk and dairy products the risk of acne development is significantly higher than among those persons, who consume such products significantly less frequently. © IDOSI Publications, 2013. Source


Oshakbayev K.P.,Republican Scientific Center for Emergency Medicine | Alibek K.,Republican Scientific Center for Emergency Medicine | Olegovich Ponomarev I.,Republican Scientific Center for Emergency Medicine | Nurlanovich Uderbayev N.,Republican Scientific Center for Emergency Care | Abayevna Dukenbayeva B.,Astana Medical University
American Journal of Case Reports | Year: 2014

Background: The aim of this case report is to present the results of treatment of end-stage ovarian carcinoma in a 41-yearold women using weight loss therapy. Case Report: We describe the case of a female aged 41 years with epithelial invasive ovarian cancer of III-IV stage, T3N2M1. Concurrent diseases were: Abdominal carcinomatosis; hepatomegaly; ascites; condition after laparocentesis and skin-abdominal fistula; condition after 6 courses of neo-adjuvant polychemotherapy; hypertension II stage, risk factor of 3-4; dyslipidemia; and metabolic syndrome. A weight loss method based on a very-low-calorie diet and physical activity was used. Body weight was reduced from 74 kg to 53 due to loss of adipose tissue after 6 months of therapy. At the same time, the percentages of water and muscle tissue were increased significantly. While overweight was reducing, clinical, laboratory, and instrumental results were improving. As a result of the weight loss therapy, about »100 mm-sized ovarian cancer was transformed into smaller-sized ovarian cysts. Conclusions: An analgesic effect was also achieved without use of narcotic or non-narcotic analgesics. These cyto-reversible processes were documented by laboratory and instrumental data. The mechanisms behind these differences remain to be elucidated. Future research with a larger study cohort and longer follow-up is needed to further investigate the role of caloric restriction diet in cancer cell changes in ovarian cancer. © Am J Case Rep, 2014. Source

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