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SALT LAKE CITY, Oct. 27, 2016 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ:MYGN), a leader in molecular diagnostics and personalized medicine, today announced it will present two new studies at the American Society of Dermatopathology (ASDP) annual meeting being held Oct. 27-30, 2016 in Chicago, Ill.  The research being presented validates the accuracy of Myriad myPath® Melanoma in differentiating benign skin nevi from malignant melanoma. “We are presenting landmark data from the largest outcomes-based study ever performed with a melanoma diagnostic,” said Loren Clarke, M.D., medical director, Dermatology, Myriad Genetic Laboratories.  “The myPath Melanoma test performed very well and identified patients with melanoma versus benign skin lesions with greater than 95 percent diagnostic accuracy, which is exceptional in molecular diagnostics for cancer, particularly given the extreme heterogeneity of melanoma.” “Pigmented or suspect skin lesions are difficult to diagnose in approximately 15 percent of cases,” said Sancy Leachman, M.D., Ph.D., chair of the Department of Dermatology in the Oregon Health & Science University School of Medicine and director of the Melanoma Research Program at the Knight Cancer Institute.  “A highly accurate biomarker like the myPath Melanoma test should help dermatologists augment their diagnosis of melanoma, improve patient care and lower healthcare costs.” Below are the featured presentations at ASDP (#ASDP2016). Poster Presentation Title: Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcome​. Presenter: Jennifer Ko. Date: Friday, Oct. 28, 2016: 4:15 – 5:00 p.m. and Saturday, Oct. 29, 2016 10:00 – 10:45 a.m. CT. In this study, research collaborators from the Cleveland Clinic, Stanford University and Nottingham University assessed the clinical accuracy (sensitivity and specificity) of the myPath Melanoma test against clinical outcomes in 182 patients with skin lesions (99 melanomas and 83 nevi) with more than 5 years of follow up.  The results show that the myPath Melanoma test accurately differentiated benign lesions from melanoma with a sensitivity of 93.8 percent and a specificity of 96.2 percent when compared to known clinical outcomes.   The diagnostic accuracy of the myPath Melanoma test was high even in a subset of difficult-to-diagnose cases and, in combination with two previous validation studies, the findings support its use as an adjunct method for the early and accurate diagnosis of melanoma. Podium Presentation Title: Gene Expression Signature as an Ancillary Method in the Diagnosis of Desmoplastic Melanoma​. Presenter: Loren Clarke. Date: Sunday, Oct. 30, 2016: 8:20 – 8:30 a.m. CT. The objective of this study was to assess the accuracy of the myPath Melanoma test in the differentiation of desmoplastic melanoma (DM) from benign skin lesions.  These lesions represent approximately one percent of melanomas, but are known to be very difficult to diagnose.  The analysis included samples from 20 patients with DM and 27 from patients with benign moles (nevi).  The results showed that the myPath Melanoma test was positive in 15 of the 20 known melanomas, negative in four and indeterminate in one.  The myPath score was negative in 24 of the benign nevi and indeterminate in three.  Based on these findings, the myPath Melanoma test demonstrated approximately 80 percent diagnostic accuracy in this very difficult-to-diagnose subtype. For more information about the meeting, please visit the ASDP website at https://www.asdp.org/annual-meeting/home/.  Follow Myriad on Twitter via @MyriadGenetics to stay informed about news and updates from the Company. About Melanoma Melanoma is one of the fastest growing cancers in the United States and can strike people of all ages, races and skin types. With a one-in-50 lifetime risk of developing melanoma, nearly 76,000 Americans are expected to be diagnosed with Stage I-IV melanoma and another 68,000 will be diagnosed with melanoma in situ – totaling approximately 144,000 total diagnoses.  Early and accurate diagnosis of melanoma is critical for long-term survival.  For more information visit: www.mypathmelanoma.com/ and www.myriadpro.com/melanoma. About Myriad myPath® Melanoma Myriad myPath Melanoma is a clinically validated test to be used as an adjunct to histopathology when the distinction between a benign nevus and a malignant melanoma cannot be made confidently by histopathology alone. The test measures the expression of 23 genes and accurately distinguishes melanoma from benign nevi. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, EndoPredict, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, Vectra, Prolaris and GeneSight are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G Safe Harbor Statement This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the Company presenting two new studies at the American Society of Dermatopathology Annual Meeting being held Oct. 27-30, 2016 in Chicago, Ill.; the accuracy and effectiveness of Myriad myPath Melanoma testing in differentiating benign skin nevi from malignant melanoma; and the Company’s strategic directives under the captions “About Myriad myPath Melanoma” and “About Myriad Genetics.” These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks and uncertainties include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests, including unexpected costs and delays; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of a healthcare clinic in Germany and Sividon Diagnostic and our planned acquisition of Assurex Health; risks related to our projections about our business, results of operations and financial condition; risks related to the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


Globally the market for pharmacogenomics is increasing rapidly mainly due to increasing safety in drug. The factors that influence the growth of Pharmacogenomics market; rising utilization in medication revelation processes, increasing interest for customized drugs, expanding security in treatment, Improve evidence of guideline for adequacy trials. • Myriad Genetics, Inc (U.S) • Transgenomic, Inc(U.S) • 23andMe (U.S) • Pathway Genomics (CA) • Genetech (CA) • GeneDX (U.S) • Teva Pharmaceutical Industries Ltd.(Israel) • Illumina, Inc.(U.s) • Assurex Health, Inc.(U.s) The report for Pharmacogenomics of Market Research Future comprises of extensive primary research along with the detailed analysis of qualitative as well as quantitative aspects by various industry experts, key opinion leaders to gain the deeper insight of the market and industry performance. The market for pharmacogenomics is segmented into mainly three; by application, by therapeutic application, by end user and its various sub-segments. By application include drug safety, Tailor treatments, drug discovery and others. Whereas by therapeutic application include cancer, oncology, cardiovascular and others. Furthermore by methods include haplotype analysis, multivariate techniques, quantitative trait analysis and others. Taste the market data and market information presented through more than 50 market data tables and figures spread in 120 numbers of pages of the project report. Avail the in-depth table of content TOC & market synopsis on “Global Pharmacogenomics Market Research Report - Forecast to 2027” • To provide detailed analysis of the market structure along with forecast for the next 10 years of the various segments and sub-segments of the global pharmacogenomics market • To provide insights about factors affecting the market growth • To Analyze the Pharmacogenomics Market based on various factors- price analysis, supply chain analysis, porters five force analysis etc. • To provide historical and forecast revenue of the market segments and sub-segments with respect to four main geographies and their countries- Americas, Europe, Asia, and Middle East & Africa. • To provide country level analysis of the market with respect to the current market size and future prospective • To provide country level analysis of the market for segment by application, by therapeutic application, by methods and its sub-segments. • To provide strategic profiling of key players in the market, comprehensively analyzing their core competencies, and drawing a competitive landscape for the market • To track and analyze competitive developments such as joint ventures, strategic alliances, mergers and acquisitions, new product developments, and research and developments in the global pharmacogenomics market. Americas • North America • US • Canada • Latin America Europe • Western Europe • Germany • France • Italy • Spain • UK • Rest of Western Europe • Eastern Europe Asia– Pacific Asia • China • India • Japan • South Korea • Rest of Asia Pacific The Middle East& Africa The report gives the clear picture of current market scenario which includes historical and projected market size in terms of value and volume, technological advancement, macro economical and governing factors in the market. The report provides details information and strategies of the top key players in the industry. The report also gives a broad study of the different market segments and regions. Global Infusion Systems market, by Product Type (Ambulatory Pumps, I.V. Disposables, Syringe Pump Systems, Volumetric Pump Sets and others), by applications (chemotherapy, cardiovascular diseases, Diabetes, Pediatrics and others) by end users (Hospitals, Clinics, Research Laboratories and others) - Forecast to 2027 https://www.marketresearchfuture.com/reports/infusion-systems-market At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research & Consulting Services. MRFR team have supreme objective to provide the optimum quality market research and intelligence services to our clients. Our market research studies by products, services, technologies, applications, end users, and market players for global, regional, and country level market segments, enable our clients to see more, know more, and do more, which help to answer all their most important questions. For more information, please visit https://www.marketresearchfuture.com/reports/pharmacogenomics-market


SALT LAKE CITY, Feb. 23, 2017 (GLOBE NEWSWIRE) -- Assurex Health, a wholly-owned subsidiary of Myriad Genetics, Inc. (NASDAQ:MYGN), today announced that new data on the use of the GeneSight® Psychotropic test to deliver medication cost savings for mental health disorders was published in the journal Clinical Therapeutics.[1]  GeneSight Psychotropic is a precision medicine genetic test that helps guide medication selection in patients with major depressive disorder (MDD) and is the foundation of the Company’s industry-leading portfolio of tests for neuroscience disorders. The study, entitled: "Economic utility: Combinatorial Pharmacogenomics and Medication Cost Savings for Mental Healthcare in a Primary Care Setting" is a subanalysis from a previous prospective study analyzing cost savings for patients receiving combinatorial pharmacogenomic testing.[2]  The current study compared savings among various types of health care providers (HCPs) and analysed the cost of treatment decisions that were congruent with GeneSight test results (i.e., medication decisions in concordance with the patients’ test results) with those that were incongruent.  Using pharmacy claims data from 2,168 patients with MDD, the new analysis compared medication costs six months prior to GeneSight testing and for one year post-testing. The analysis measured both treatment congruence and cost savings per patient based on the type of healthcare provider administering care.  The findings showed that primary care providers (PCPs) treat the majority of mental health patients receiving psychotropic medication prescriptions, including treatment resistant patients.  In fact, patients treated by PCPs had tried a median of five medications, similar to psychiatrists whose patients had tried six medications. The data also demonstrated that PCPs who treated patients congruently with the GeneSight test saved payers and patients an average of $3,998 compared to incongruent decisions (p<0.001).  Additionally, psychiatrists who treated patients congruently with the GeneSight test saved an average of $1,308. [1] Brown L., Lorenz R., Li J., et al, Economic utility:  Combinatorial pharmacogenomics and medication cost savings for mental healthcare in a primary care setting.  Clin Ther. 2017; Accessed online at: http://dx.doi.org/10.1016/j.clinthera.2017.01.022. [2] J.G. Winner, J.M. Carhart, C.A. Altar, et al. Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation. Curr Med Res Opin, 31 (2015), pp. 1633–1643. "In the treatment of major depression, clinicians and payers are looking for sensible options to improve patient care, while lowering overall costs to healthcare systems," said Bryan M. Dechairo, Ph.D., chief medical and science officer, Assurex Health. "Prior studies demonstrated that the GeneSight test can be used to guide patient treatment decisions. Now, we know that GeneSight can lower costs across healthcare provider types, but was especially effective in generating cost savings among primary care physicians, which is important because they treat the majority of patients with mental illness.” Follow Myriad on Twitter via @MyriadGenetics to stay informed about news and updates from the Company. About The GeneSight® Test The GeneSight test helps healthcare providers make better treatment decisions based on a person’s genetic makeup. GeneSight testing is based on advanced CPGx® technology, a patented approach that analyzes variations and combinations of a person’s genes along with FDA-approved medications for behavioral health conditions and chronic pain.  Numerous peer-reviewed, published studies have proven its clinical benefits and substantial healthcare cost savings. More than 18,000 healthcare professionals have used GeneSight to improve healthcare for more than 450,000 patients. Learn more at www.GeneSight.com. About Assurex Health Assurex Health, a wholly-owned subsidiary of Myriad Genetics, Inc., is an informatics-based, personalized medicine company providing treatment decision support to healthcare providers for behavioral health and chronic pain conditions. Assurex Health is the only company in the category with multiple peer-reviewed, published studies that demonstrate the clinical validity and clinical utility of the GeneSight test, including its substantial healthcare cost savings benefit. The Company has grown every quarter and has expanded internationally through a partnership with Canada’s Centre for Addiction and Mental Health (CAMH). For more on how Assurex Health is helping people gain mental wellness, visit www.AssurexHealth.com. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, EndoPredict, Vectra, GeneSight and Prolaris are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G. Safe Harbor Statement This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the ability of the GeneSight Psychotropic test to drive medication cost savings for mental health disorders; the ability of the GeneSight test to guide medication selection in patients with major depressive disorder (MDD); GeneSight test being the foundation of the Company’s industry-leading portfolio of tests for neuroscience disorders; and the Company’s strategic directives under the caption “About Myriad Genetics.”  These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of Assurex, Sividon and the Clinic; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; the risk that we may be unable to comply with financial operating covenants under our credit or lending agreements;  the risk that we will be unable to pay, when due, amounts due under our credit or lending agreements; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


SALT LAKE CITY, Nov. 04, 2016 (GLOBE NEWSWIRE) -- Assurex Health, a wholly-owned subsidiary of Myriad Genetics, Inc. (NASDAQ:MYGN), today announced that a poster featuring the GeneSight® test will be presented at the Neuroscience Education Institute (NEI) Psychopharmacology Congress being held Nov. 3-6, 2016 in Colorado Springs, Colo. In this subanalysis of a previously published study, patients with generalized anxiety disorder (GAD) experienced significant cost savings when decisions congruent with the GeneSight report were made by healthcare providers.  In the previously published study, congruency with the GeneSight test was shown to deliver significant cost savings for patients with major depressive disorder (MDD). “We believe that GeneSight has the potential to improve outcomes for patients being treated with psychotropic drugs and eliminate a significant amount of waste in our healthcare system,” said Bryan M. Dechairo, Ph.D., chief medical and science officer, Assurex Health. “We look forward to sharing these data with the medical community and payers.” Below is a summary of the featured presentation at NEI (#NEI2016). Poster Presentation Title: GeneSight Psychotropic Decreases Medication Costs for Patients with Anxiety and Bipolar Disorders in a Large, Prospective Case-Control Project Presenter: Kim Horn. Date: Friday, Nov. 4, 2016: 6:00-7:30 p.m. MT. This study assessed the economic utility of the GeneSight test for 318 patients with generalized anxiety disorder (GAD) when healthcare providers made decisions congruent with the GeneSight test report. Patients in the GeneSight-guided group of the previously published study were subdivided into two groups. The first group included patients whose healthcare provider made treatment decisions congruent with the GeneSight test report. The second group included patients whose provider made treatment decisions incongruent with the test report. The analysis compared total medication costs between the congruent and incongruent groups for patients based on their diagnosis of GAD. The results showed that, for GAD patients, the savings for congruent versus incongruent decisions was $6,747 per member per year ($5736 vs $12,483, p<0.004). Importantly, GAD patients experienced greater savings in CNS medications (2-fold), antineoplastic medications (2.5-fold) and gastroenterology medications (2.8-fold). Patients with comorbid GAD and MDD whose medication regimens were congruent with the GeneSight test had the highest cost savings of any group ($10,573). This subanalysis showed significant cost savings for GAD patients when healthcare providers made decisions congruent with the GeneSight test report. Much of the cost savings came from classes of medicines used in primary care. Anxiety disorders are commonly seen in the primary care setting and are often associated with comorbid medical illnesses, such as heart disease, migraine headaches and back pain for which patients with anxiety often seek help from their primary care provider. The GeneSight test may have enabled healthcare providers to more appropriately treat the underlying anxiety disorder, thereby reducing the number of physical complaints that previously required medication. Additionally, the previously published study showed that patients whose treatment was guided by the GeneSight test experienced increased adherence and reduced polypharmacy, which may have also contributed to cost savings associated with primary care medications. About The GeneSight® Test GeneSight testing helps healthcare providers make better treatment decisions based on a person's genetic makeup. GeneSight testing is based on advanced CPGx® technology, a patented approach that analyzes variations and combinations of a person's genes along with FDA-approved medications for behavioral health conditions and chronic pain. Peer-reviewed, published studies have proven its clinical benefits and substantial healthcare cost savings. More than 15,000 healthcare professionals have used GeneSight with over 400,000 patients. Learn more at www.GeneSight.com. About Assurex Health Assurex Health, a wholly-owned subsidiary of Myriad Genetics, Inc., is an informatics-based, personalized medicine company providing treatment decision support to healthcare providers for behavioral health and chronic pain conditions. Assurex helps people achieve mental wellness with advanced CPGx®, a proprietary combinatorial pharmacogenomics technology that provides individualized treatment support for neuropsychiatric conditions. Assurex Health is the only company in the category with multiple peer-reviewed, published studies that demonstrate the clinical validity and clinical utility of the GeneSight® test, including its substantial healthcare cost savings benefit. The Company has grown every quarter and has expanded internationally through a partnership with Canada's Centre for Addiction and Mental Health (CAMH). For more on how Assurex Health is helping people gain mental wellness, visit www.AssurexHealth.com. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics. Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs. Myriad is focused on three strategic imperatives: transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets. For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, EndoPredict, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, Vectra, Prolaris and GeneSight are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G Safe Harbor Statement This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the Company presenting a new study at the Neuroscience Education Institute Annual Meeting being held Nov. 3-6, 2016 in Colorado Springs, Colo.; the accuracy and effectiveness of the GeneSight test in selecting psychotropic drug therapy or saving the healthcare system money; and the Company’s strategic directives under the captions “About GeneSight” and “About Myriad Genetics.”  These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of Assurex, Sividon and the Clinic; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; the risk that we may be unable to comply with financial operating covenants under our credit or lending agreements; the risk that we will be unable to pay, when due, amounts due under our credit or lending agreements; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


News Article | December 19, 2016
Site: www.businesswire.com

CAPE CANAVERAL, Fla.--(BUSINESS WIRE)--Comprehensive Health Services, one of the nation’s largest and most experienced workforce medical services providers, has hired Patrick Hogenbirk as senior vice president and chief compliance officer. This position reports to President and CEO Gary Palmer, with additional reporting responsibilities to the company’s board of directors. Hogenbirk has more than 20 years of experience in corporate ethics and compliance. Most recently, Hogenbirk served as vice president and chief compliance officer with Assurex Health, a personalized medicine company, specializing in DNA-based drug treatment. He has held similar positions at Johnson & Johnson and Cardinal Health, where he was instrumental in establishing new ethics and compliance programs. “Comprehensive Health Services continues to grow, and with this growth comes increased operational complexities, requiring company-wide oversight,” said President and CEO Gary Palmer. “This position is in response to our expanding needs. We are committed to maintaining the highest ethical standards and full compliance on every contract and throughout our operations, functions, and processes, and the addition of Patrick to our senior leadership team reinforces our strong commitment and dedication.” Hogenbirk holds a Certified Compliance and Ethics Professional certificate from the Society of Corporate Compliance, and an Ethics and Healthcare Compliance Law certificate from Seton Hall University Law School and is a graduate of the University of Maryland and Park University. Hogenbirk is a veteran of the U.S. Air Force and retired as a Chief of Fire Protection for the 4th Air Force with more than 25 years of service. Founded in 1975, Comprehensive Health Services is one of the nation’s largest and most experienced providers of workforce medical services. We partner with Fortune 1000 companies and the U.S. government to solve the highly complex, large-scale health care challenges they face by implementing and managing cost-effective, customized medical programs for large and dispersed workforces. Our technology-driven, flexible health care solutions are capable of providing tailored services to ensure employers can meet the medical needs and compliance issues of their employees anywhere in the world. For more information, please visit www.chsmedical.com. For news and updates, follow us on Twitter @CHSMedical, LinkedIn, or like us on Facebook.


News Article | November 11, 2016
Site: www.newsmaker.com.au

MarketStudyReport.com adds “Medical Equipment Monthly Deals Analysis: August 2016 - M&A and Investment Trends” new report to its research database. The report spread across 84 pages with table and figures in it. Medical Equipment Monthly Deals Analysis: August 2016 - M&A and Investment Trends? report is an essential source of data and trend analysis on the mergers and acquisitions (M&As) and financings in the medical equipment industry. The report provides detailed information on M&As, equity/debt offerings, private equity, venture financing and partnership transactions registered in the medical equipment industry in August 2016. The report portrays detailed comparative data on the number of deals and their value in the last six months, subdivided by deal types, segments and geographies. Additionally, the report provides information on the top financial advisory firms in the medical equipment industry. Browse full table of contents and data tables at https://www.marketstudyreport.com/reports/medical-equipment-monthly-deals-analysis-august-2016-ma-and-investment-trends/ 2.3.4 Myriad Genetics to Acquire Assurex Health for up to USD410 Million 14 4.1.1 In Vitro Diagnostics - Deals of the Month 28 4.2.1 Healthcare IT - Deals of the Month 31 Scope - Analyze market trends for the medical equipment/medical devices market in the global arena - Review of deal trends in anesthesia and respiratory devices, cardiovascular devices, dental devices, diabetes care devices, diagnostic imaging, drug delivery devices, endoscopy devices, ENT devices, healthcare IT, hospital supplies, in vitro diagnostics, nephrology and urology devices, neurology devices, opthalmic devices, patient monitoring, surgical equipment, and wound care management segments - Analysis of M&A, Equity/Debt Offerings, Private Equity, Venture Financing and Partnerships in the medical equipment market - Summary of medical equipment deals globally in the last six months - Information on the top deals that took place in the medical equipment market - Geographies covered include - North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa - League Tables of financial advisors in M&A and equity/debt offerings. This includes key advisors such as Morgan Stanley, Credit Suisse, and Goldman Sachs - Review the financial metrics, such as operating profit ratio, P/E ratio, and EV/EBITDA on mergers and acquisitions Reasons to buy - Enhance your decision making capability in a more rapid and time sensitive manner. - Find out the major deal performing segments for investments in your industry. - Evaluate the types of company divesting and acquiring assets and ways to raise capital in the market. - Do deals with an understanding of how competitors are financed, and the mergers and partnerships that have shaped the medical equipment industry. - Identify growth segments and opportunities in each region within the industry. - Look for key financial advisors where you are planning to raise capital from the market or for acquisitions within the industry To receive personalized assistance, write to us @ [email protected] with the report title in the subject line along with your questions or call us at +1 866-764-2150


CINCINNATI--(BUSINESS WIRE)--Meridian Bioscience, Inc. announces that on August 11, 2015, the Board of Directors of Meridian Bioscience, Inc. elected two new independent directors, Catherine A. Sazdanoff and John C. McIlwraith, effective August 14, 2015. Ms. Sazdanoff is the CEO and President of Sazdanoff Consulting LLC, specializing in business development, management and strategy consulting. In addition, she is Strategic Advisor to mProve Health LLC, a mobile health technology company located in Arlington, Virginia. From 2006 to 2015, Ms. Sazdanoff held a number of executive positions with Takeda Pharmaceutical International, Inc. including Vice President, Head of Corporate Projects, VP, Global Business Development and VP, Corporate Development. Prior to her time at Takeda, Ms. Sazdanoff spent 22 years with Abbott Laboratories, where she held numerous executive positions. Ms. Sazdanoff received a B.A. from the University of Notre Dame and a J.D. from Northwestern University School of Law. Mr. McIlwraith co-founded Allos Ventures, a venture capital firm, in March 2010 and has served as a Managing Director there since that time. Prior to founding Allos Ventures, Mr. McIlwraith was a Managing Director of Blue Chip Venture Company, a Cincinnati-based venture capital and private equity firm, which he joined in 1997. He has served on the board of directors of more than 20 healthcare or information technology companies, and is currently the lead director of Assurex Health, Inc., an informatics-based precision medicine company providing treatment decision support to health care providers for behavioral health conditions. Prior to 1997, Mr. McIlwraith served as Senior Vice President of Strategic Planning and General Counsel of publicly-traded Quantum Health Resources, Inc., and was a partner in the Jones Day law firm. Mr. McIlwraith received a B.A. from Hillsdale College and a J.D. from Case Western Reserve University. John A. Kraeutler, Chairman and Chief Executive Officer, commented, “With the election of Catherine and John to the Board of Directors of Meridian Bioscience we have added key strategic and operating strengths to help guide our future growth. Our Nominating Committee has been working diligently for more than a year to add specific skills to the Board. During that period, we have met and interviewed many talented individuals and we are very pleased that Catherine and John have agreed to join our team. I look forward to working closely with both Catherine and John, along with our existing directors, as we build a strong future for Meridian Bioscience.” Meridian is a fully integrated life science company that develops, manufactures, markets and distributes a broad range of innovative diagnostic test kits, purified reagents and related products and offers biopharmaceutical enabling technologies. Utilizing a variety of methods, these products and diagnostic tests provide accuracy, simplicity and speed in the early diagnosis and treatment of common medical conditions, such as gastrointestinal, viral and respiratory infections. Meridian’s diagnostic products are used outside of the human body and require little or no special equipment. The Company's products are designed to enhance patient well-being while reducing the total outcome costs of health care. Meridian has strong market positions in the areas of gastrointestinal and upper respiratory infections, serology, parasitology and fungal disease diagnosis. In addition, Meridian is a supplier of rare reagents, specialty biologicals and related technologies used by biopharmaceutical companies engaged in research for new drugs and vaccines. The Company markets its products and technologies to hospitals, reference laboratories, research centers, diagnostics manufacturers and biotech companies in more than 60 countries around the world. The Company’s shares are traded on the NASDAQ Global Select Market, symbol VIVO. Meridian's website address is www.meridianbioscience.com.


Assurex Health, a precision medicine company providing industry-leading treatment decision support to healthcare providers for behavioral health and chronic pain conditions, today announced that its new, 60,000 square-foot headquarters and laboratory will anchor a mixed-use development in Mason’s Oak Park District. Adding to the district’s growing bioscience and high tech investment, the new facility is anticipated to be built on 30 acres on Innovation Way just off the Western Row exit of I-71. Part of New “Business Gateway” to Mason Assurex Health has retained the Tenant Advisory Group at DTZ to manage the design and development of the facility, which will incorporate a plan for an additional 30,000 square-foot expansion space. DTZ also will lead the development of a master plan for the entire 30 acre site with Assurex Health and the City of Mason, according to Donald R. Wright, Chief Operating Officer at Assurex Health, to ensure it can effectively accommodate a larger bioscience mixed-use campus. The site will be near a new, planned 1-71 interchange which will create a new business “gateway” to the city. DTZ is a global leader in commercial real estate services providing occupiers, tenants and investors around the world with a full spectrum of property solutions. “Assurex Health is the perfect partner to anchor what will be a key asset within our bioscience cluster and pivotal development for the Oak Park District,” said City of Mason Mayor David F. Nichols. “We look forward to working closely with Assurex Health leadership and DTZ to make this a marque site that will showcase what a strong public private partnership can achieve. “ The Assurex Health headquarters will be designed to encourage employee wellness and to nurture a collaborative, entrepreneurial culture as the company grows. In the past three years, Assurex Health has more than tripled its employment to nearly 300 and quadrupled the number of patients that have received its GeneSight® tests to more than 140,000. “We are appreciative of the support we continue to receive from Mason and the State of Ohio,” said President and CEO Virginia C. Drosos. “Mason has a strong commitment to health care and community wellness. This is a great environment for our company and employees.” DTZ’s first task is to identify architects for the project. Assurex Health expects to choose a firm by June 1 and have initial drawings by July 1. “This site offers great access to our regional science partners and to top talent,” said Wright. “We also want to ensure it is integrated into the community. Our discussions about the vision of the site and how it can bring to life the culture of wellness and creativity and innovation in our company and in Mason are exciting.” It is anticipated that the project will be completed in 2016. Assurex Health is a commercial-stage, informatics-based precision medicine company providing treatment decision support to clinicians for behavioral health conditions. Assurex Health’s proprietary GeneSight technology is based on combinatorial pharmacogenomics (CPGx™) – the application of multiple genetic factors that influence an individual’s response to medications – as well as evidence-based medicine and clinical pharmacology. Assurex Health has licensed patented technology from Mayo Clinic and Cincinnati Children’s Hospital Medical Center, both of whom continue to be research collaborators. Learn more at http://www.assurexhealth.com


The combinatorial, multi-gene GeneSight test has been found to better predict antidepressant treatment outcomes for patients with depression, and their use of health care resources, than any of the individual genes that comprise the test, according to a peer-reviewed analysis by investigators from the Mayo Clinic and Assurex Health, and published online by The Pharmacogenomics Journal i. The proprietary technology of the GeneSight Psychotropic test is based on combinatorial pharmacogenomics (CPGx™), the study of how variations in multiple genes collaborate to influence an individual’s response to medications, and evidence-based medicine and the known clinical pharmacology of various drugs. “This new publication shows that the combinatorial GeneSight test predicts which patients are likely to experience poorer antidepressant outcomes and use more health care services, whereas single gene diagnostics mostly did not,” said lead author and Assurex Health Senior Vice President, C. Anthony Altar, Ph.D. “The robust evidence from these analyses reinforce the advantage of the combinatorial GeneSight test in helping clinicians guide antidepressant and anti-anxiety treatment decisions. This and other features of GeneSight distinguish our pharmacogenomic products from all others.” The GeneSight Psychotropic test helps inform clinicians’ treatment selection for commonly prescribed medications including those for depression, post-traumatic stress disorder (PTSD), anxiety, bipolar disorder and schizophrenia. The test is covered by Medicare, the U.S. Department of Veterans Affairs, and a growing number of commercial payers. The CPGx approach that generates the GeneSight report examines DNA variations of multiple genes since these variations can change the efficacy, metabolism, and adverse effects of many psychiatric drugs. Using a patient’s unique genetics, the GeneSight Psychotropic test creates a personalized report that places 38 U.S. Food and Drug Administration (FDA)-approved medications for depression and other mental health conditions into three color-coded categories for clinicians to review: “Use as Directed” in green, “Use with Caution” in yellow, or “Use with Increased Caution and with More Frequent Monitoring” in red. The GeneSight report also alerts healthcare providers to the implications of the patient’s genetic information to a drug’s dosage, and FDA-approved package insert information. Most single gene tests have high variability and are less accurate in predicting patient responses to psychotropic medications. The GeneSight approach compensates for these limitations by aggregating predictions by the drug metabolism and response genes to better predict patient’s responses. “Nearly 90 percent of antidepressant and antipsychotic medications are metabolized by at least two of the liver cytochrome P450 (CYP) enzymes, and many interact with the brain serotonin transporter (SLC6A4) or the serotonin 2A receptor (HTR2A),” explained the authors. “The GeneSight Psychotropic test accounts for this complexity by measuring and combining the DNA sequence variations within drug response and drug metabolism genes. This analysis looked at the GeneSight test that included the liver metabolism genes CYP2D6, CYP2C19, CYP2C9, and CYP1A2, and the two drug response genes, SLC6A4 and HTR2A.” Since these studies were conducted, Assurex Health has enhanced the GeneSight test to include two more genes, CYP3A4 and CYP2B6, making it the first and only psychiatric pharmacogenomic test to offer CYP3A4 analysis distinct and separate from CYP3A5. The CYP2B6 gene affects medications including bupropion (Wellbutrin®), the third most commonly prescribed antidepressant. In The Pharmacogenomics Journal article, the authors examined pooled data from three clinical trials, including two open-label studies and one randomized, double-blind controlled trial. Depression outcomes were recorded over 8 to 10 weeks for 119 fully blinded, treatment-resistant patients who were tested but neither they nor their clinicians received the GeneSight report. They were treated with standard of care and antidepressants were prescribed without pharmacogenomic guidance. After the studies were completed, the investigators used the GeneSight test results for each patient to determine the GeneSight color classification of their medications. The antidepressant outcomes of the 119 patients were predicted by the GeneSight classification (p=0.008), based on improvements of depressive symptoms measured by the Hamilton Depression scale (HAM-D17). Patients who entered the studies on one or more GeneSight red category medications showed significantly less improvement in depressive symptoms than those prescribed medications classified as yellow or green. The investigators then created five subgroups comprised of those patients who were prescribed one or more drugs that are metabolized by either of the CYP enzymes or either of the serotonin effector proteins. The GeneSight test again predicted the improvement in depressive symptoms for patients prescribed medications metabolized via the CYP2D6 (117 patients, p=0.003), CYP2C19 (80, p=0.04) or CYP1A2 (35, p=0.03) enzymes. In the exact same patient groups, clinical improvements were not predicted by either of the single gene tests based on their traditional classification of patients as poor, intermediate, extensive, or ultrarapid CYP metabolizers. This publication also reports similar findings from a retrospective chart review of medical information collected for one year of treatment for a different group of 96 depressed patients. Investigators found that the GeneSight test predicted more total healthcare visits, medical visits and disability claims among patients who had been prescribed one or more medications classified in the red category. Similar to results with depression outcomes, GeneSight predicted significantly more total healthcare visits and disability claims among patients prescribed red category medications metabolized by CYP2D6 (p=0.04, p=0.002, respectively) or CYP2C19 (p=0.04, p=0.001, respectively), and predicted total healthcare visits (p=0.01) and medical visits (p=0.02) for patients prescribed CYP1A2-metabolized drugs. In comparison, only one of the five single gene tests, that for CYP2C19, predicted differences, and only for total healthcare visits or medical visits. Multiple peer-reviewed clinical studies have demonstrated the efficacy and utility of GeneSight. Compared with the current standard of care, pooled data from these peer-reviewed studies ii ,iii, iv show that patients whose treatment was guided by GeneSight experienced a 53 percent greater improvement in depressive symptoms and double the likelihood of response compared with those not guided by the test. Studies have also shown that clinicians who incorporate GeneSight when evaluating medication decisions for their depressed patients can help reduce annual health care costs per patient by more than $2,500, potentially saving millions of dollars in healthcare expenditures.v Altar's co-authors on the paper, “Clinical Validity: Combinatorial Pharmacogenomics Predicts Antidepressant Responses and Healthcare Utilizations Better than Single Gene Phenotypes,” include Daniel Hall-Flavin, M.D., Associate Professor of Psychiatry at the Mayo Clinic, and Joseph Carhart, M.A., Josiah D. Allen, Bryan M. Dechairo, Ph.D. and Joel G. Winner, M.D., of Assurex Health. The full article can be viewed at http://genesight.com/reprint-combinatorial-pharmacogenomics. Assurex Health funded the paper. About GeneSight GeneSight helps health care providers make more precise treatment decisions based on how a patient’s unique genetic makeup affects their individual response to 38 FDA-approved medications for depression, anxiety, posttraumatic stress disorder (PTSD), bipolar disorder, schizophrenia and/or other mental health conditions. GeneSight is the only neuropsychiatric combinatorial pharmacogenomic test validated in multiple, peer-reviewed, published clinical studies. GeneSight analyzes over 785,000 permutations of an individual’s genes and available medications, and presents the results in an easy to read, color-coded report available typically within 36 hours after Assurex Health receives a patient’s cheek swab. Many commercial and government insurance plans, including Medicare and the U.S. Department of Veterans Affairs, reimburse all or part of the cost of GeneSight. Assurex Health also offers financial assistance programs for patients who qualify. Learn more at http://www.genesight.com. About Assurex Health Assurex Health is a commercial-stage, informatics-based precision medicine company providing treatment decision support to clinicians for behavioral health conditions. Assurex Health’s proprietary GeneSight technology is based on combinatorial pharmacogenomics (CPGx™) – the application of multiple genetic factors that influence an individual’s response to medications – as well as evidence-based medicine and clinical pharmacology. Assurex Health has licensed patented technology from Mayo Clinic and Cincinnati Children’s Hospital Medical Center, both of whom continue to be research collaborators. Learn more at http://www.assurexhealth.com. i Altar, CA, et al. (2015) Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes. Pharmacogenomics J advance online publication, February 17, 2015; doi:10.1038/tpj.2014.85. ii Hall-Flavin DK, et al. Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting. Pharmacogenet Genomics. 2013 Oct;23(10):535-48. [PMID: 24018772]. iii Hall-Flavin DK, et al. Using a pharmacogenomic algorithm to guide the treatment of depression. Transl Psychiatry. 2012 Oct 16;2:e172. [PMID: 23047243]. iv Winner JG, et al. A prospective, randomized double-blind study assessing the clinical impact of integrated pharmacogenomic testing for major depressive disorder. Discov Med. 2013 Nov;16(89):219-27. [PMID: 24229738]. v Winner JG, et al. Psychiatric pharmacogenomics predicts health resource utilization of outpatients with anxiety and depression. Transl Psychiatry. 2013 Mar 19;3:e242. [PMID: 23511609].


A new study published in Current Medical Research and Opinion demonstrated $1,036 in annual prescription savings per patient when healthcare providers used the GeneSight® combinatorial pharmacogenomic (CPGx) test results to guide treatment decisions compared with usual trial-and-error prescribing. CPGx is the evaluation of multiple genetic factors that influence an individual’s response to medications. Unlike other tests, GeneSight measures multiple clinically important genomic variants for each patient and weights them together – rather than one at a time – to provide comprehensive genetically driven recommendations for each medication for each patient. This is important in evaluating medication response given that most psychiatric medications work through multiple genetic pathways, both metabolically and at their point of response. GeneSight is the only neuropsychiatric pharmacogenomic test available that is based on proprietary and patented combinatorial technology. The study, based on data from more than 13,000 patients being treated for behavioral health issues, analyzed whether CPGx improves adherence and leads to cost savings. The study found that: The study compared pharmacy claims over a one year period between a patient group whose treatment was guided by GeneSight and a propensity-matched control group whose treatment was decided using traditional prescribing methods. “The results of this analysis reinforce the existing clinical evidence that using the GeneSight Psychotropic test to guide treatment decisions saves significant money,” said lead author Dr. Joel Winner, president of Winner Psychiatry in Boulder, Colorado, and medical director of Assurex Health. GeneSight is the only neuropsychiatric pharmacogenomic test covered by Medicare and available through the U.S. Department of Veterans Affairs, and proven in multiple peer-reviewed, published clinical studies to result in better patient outcomes at lower cost through enhanced medication selection. Mental Illness Direct Treatment Costs Among the Highest Direct treatment costs for mental illness far exceed those for diabetes and hypertension, and lag only behind cardiovascular disease, traumatic injury, and cancer.(i) Indirect treatment costs also are staggering, with major depressive disorder (MDD) responsible for the highest disability costs among all major illnesses.(ii) The National Institute of Mental Health reports that annual direct and indirect costs for depression are $200 billion(iii) with annual psychiatric medication costs of $30.3 billion.(i) One in four adults suffers from a mental illness in any given year.(iv) MDD is one of the most common among these illnesses with a one year prevalence of 6.7 percent.(iv) Many individuals suffering from MDD do not receive treatment because of social stigma, financial outlay, and limited access to healthcare.(iv) Of those who do pursue treatment, two-thirds do not achieve full remission. Instead, they often end up on a pharmacologic odyssey requiring multiple failed medications to ultimately find a medication with a favorable risk/benefit balance.(v) This perpetuation of treatment-resistant depression results in greater loss of work productivity and disability, and 70 percent higher annual medical costs than for treatment-responsive patients.(vi) Study Analyzes Significant Patient Population The study compared pharmacy claims over one year between a prospectively generated cohort of GeneSight tested subjects (n = 2,168) and a 5-to-1 clinically and demographically matched control group (n = 10,880) selected from a pool of approximately 65 million eligible Medco plan members. Patients were eligible for either group if they were newly starting an antidepressant or antipsychotic medication, or were augmented or switched to a different antidepressant or antipsychotic medication and maintained continual pharmacy benefits eligibility from six months prior to the initial prescription to the date of the new medication. Both groups were followed for one year. Prescription medication claims data were analyzed for differences between the two groups and within the GeneSight group based on medication changes that were consistent or inconsistent with each participant’s GeneSight results. “The size of the study, significant health care cost savings and increased adherence by patients are compelling,” said Gabriela Lavezzari, AVP, Scientific & Regulatory Affairs at PhRMA, formerly of Medco Health Solutions. “It is evident that GeneSight precision medicine testing can offer a true benefit to patients and to their prescribing physicians.” The full study is available at http://genesight.com/medcostudy About GeneSight GeneSight helps health care providers make more precise treatment decisions based on how a patient’s unique genetic makeup affects their individual response to 38 FDA-approved medications for depression, anxiety, posttraumatic stress disorder (PTSD), bipolar disorder, schizophrenia and other mental health conditions. GeneSight is the only neuropsychiatric combinatorial pharmacogenomic test validated in multiple, peer-reviewed, published clinical studies. GeneSight analyzes over 785,000 permutations of an individual’s genes and available medications, and presents the results in an easy to read, color-coded report available typically within 36 hours after Assurex Health receives a patient’s cheek swab. Many commercial and government insurance plans, including Medicare and the U.S. Department of Veterans Affairs, reimburse all or part of the cost of GeneSight. Assurex Health also offers financial assistance programs for patients who qualify. About Assurex Health Assurex Health is a commercial-stage, informatics-based precision medicine company providing treatment decision support to health care providers for behavioral health conditions. Assurex Health’s proprietary GeneSight technology is based on combinatorial pharmacogenomics (CPGx™) – the application of multiple genetic factors that influence an individual’s response to medications – as well as evidence-based medicine and clinical pharmacology. Assurex Health has licensed patented technology from Mayo Clinic and Cincinnati Children’s Hospital Medical Center, both of whom continue to be research collaborators. (i)    Agency for Health care Research and Quality. Total Expenses and Percent Distribution for Selected Conditions by Type of Service: United States, 2011. Medical Expenditure Panel Survey Household Component Data. Generated interactively. (October 20, 2014). (ii)     Mrazek DA, Hornberger JC, Altar CA, Degtiar I. A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013. Psychiatr Serv. 2014;65(8):977-87. (iii)     National Institute of Mental Health: Annual Total Direct and Indirect Costs of Serious Mental Illness (2002) .(29 July 2010) "Annual Total Direct and Indirect Costs of Serious Mental Illness (2002)" Retrieved from http://www.nimh.nih.gov/health/statistics/cost/index.shtml (iv)     NAMI. Numbers of Americans Affected by Mental Illness. Mental Illness Facts and Numbers http://www.nami.org/factsheets/mentalillness_factsheet.pdf. Accessed October 20, 2013. (vi)     Mrazek DA, Hornberger JC, Altar CA, Degtiar I. A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013. Psychiatr Serv. 2014;65(8):977-87.

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