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Cetinkaya M.,Assisted Reproductive Techniques and Reproductive Genetics Center | Pirkevi C.,Assisted Reproductive Techniques and Reproductive Genetics Center | Yelke H.,Assisted Reproductive Techniques and Reproductive Genetics Center | Colakoglu Y.K.,Assisted Reproductive Techniques and Reproductive Genetics Center | And 2 more authors.
Journal of Assisted Reproduction and Genetics

Purpose: Morphology alone is not enough for the selection of the embryo (s) with the highest implantation potential and time-lapse imaging has added embryo development kinetics as another selection criterion. Therefore, a combination of morphology with kinetics has inspired a new field termed “morphokinetics”, providing a new way of evaluating and selecting embryos. The aim of the study was to identify a criterion solely based on morphokinetic data and available up to the 8-cell stage (t8) to predict blastocyst formation and quality.Methods: The study included 3,354 embryos, with annotations up to t8, and cultured until day 5 from 626 infertile patients. A total of 17 kinetic expressions, either absolute cleavage timings and time intervals or time ratios were tested retrospectively for the prediction of blastocyst formation and quality.Results: Relative timings (t8-t5, the cleavage synchronicity from 4 to 8 cells and from 2 to 8 cells) were found to be better indicators of blastocyst formation and quality when compared to absolute time-points. Especially, the cleavage synchronicity from 2 to 8 cells (CS2-8) = ((t3-t2) + (t5-t4))/(t8-t2)) was found to be the best predictor available on day 3 for blastocyst formation and quality (AUC:0.786; sensitivity: 83.43; specificity: 62.46).Conclusions: Time intervals and relative ratios based on selected cleavage cycles defining synchronicity allowed a specific analysis providing high predictivity of blastocyst formation and quality. © 2014, The Author(s). Source

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