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Bosnjak I.,Laboratory for Biology and Microbial Genetics | Borra M.,Stazione Zoologica Anton Dohrn | Iamunno F.,Stazione Zoologica Anton Dohrn | Benvenuto G.,Stazione Zoologica Anton Dohrn | And 5 more authors.
Aquatic Toxicology | Year: 2014

Usage of bisphenol A (BPA) in production of polycarbonate plastics has resulted in global distribution of BPA in the environment. These high concentrations cause numerous negative effects to the aquatic biota, among which the most known is the induction of endocrine disruption. The focus of this research was to determine the effects of two experimentally determined concentrations of BPA (100. nM and 4. μM) on cellular detoxification mechanisms during the embryonic development (2-cell, pluteus) of the rocky sea urchin (Paracentrotus lividus), primarily the potential involvement of multidrug efflux transport in the BPA intercellular efflux. The results of transport assay, measurements of the intracellular BPA and gene expression surveys, for the first time indicate the importance of P-glycoprotein (P-gp/ABCB1) in defense against BPA. Cytotoxic effects of BPA, validated by the immunohistochemistry (IHC) and the transmission electron microscopy (TEM), induced the aberrant karyokinesis, and consequently, the impairment of embryo development through the first cell division and retardation. © 2014 Elsevier B.V.


PubMed | Croatian Institute Of Oceanography And Fisheries, Assemble, Stazione Zoologica Anton Dohrn and Laboratory for Biology and Microbial Genetics
Type: | Journal: Aquatic toxicology (Amsterdam, Netherlands) | Year: 2014

Usage of bisphenol A (BPA) in production of polycarbonate plastics has resulted in global distribution of BPA in the environment. These high concentrations cause numerous negative effects to the aquatic biota, among which the most known is the induction of endocrine disruption. The focus of this research was to determine the effects of two experimentally determined concentrations of BPA (100nM and 4M) on cellular detoxification mechanisms during the embryonic development (2-cell, pluteus) of the rocky sea urchin (Paracentrotus lividus), primarily the potential involvement of multidrug efflux transport in the BPA intercellular efflux. The results of transport assay, measurements of the intracellular BPA and gene expression surveys, for the first time indicate the importance of P-glycoprotein (P-gp/ABCB1) in defense against BPA. Cytotoxic effects of BPA, validated by the immunohistochemistry (IHC) and the transmission electron microscopy (TEM), induced the aberrant karyokinesis, and consequently, the impairment of embryo development through the first cell division and retardation.


News Article | December 7, 2016
Site: www.prweb.com

Assemble Systems, the leading provider of Construction Data Management solutions, recently unveiled the next major enhancement to its award winning software, Assemble Insight. With this significant addition, AEC professionals can access 2D drawings within Assemble alongside 3D models. Assemble Systems is known for its innovative approach to improving preconstruction and construction workflows through use of models and associated metadata. The company has earned numerous industry awards for being an industry leader in driving technology adoption in the construction industry. The integration of 2D and 3D within Insight was first revealed at the Assemble Systems Advisory Board Meeting at Autodesk University in November. The Assemble advisory board consists of key industry professionals from top contractors in the AEC industry that help guide the product roadmap by providing valuable feedback and professional insight. “We work closely with our customers to deliver innovative solutions that focus on improving processes and expanding the use of the models across different roles and project lifecycle,” said Mark Klusza, CIO, Assemble Systems. “We take a collaborative approach to prioritizing the enhancements we deliver to our valued customers. We wanted to make it easier for the project team to fully understand every aspect of a project by enabling access to all types of documents including 2D, 3D and model information in an all inclusive easy-to-use environment. According to our customers with this latest enhancement, we are delivering just that.” The reaction to the integration at the board meeting and Autodesk University was excellent. The customers were impressed with how easily they were able to navigate between the 2D documents and 3D models. “By providing instant access to relevant sheets and providing 3D context, we are bridging the gap between the BIM/VDC team, estimating departments and the field teams,” said Howard Davis, CEO, Assemble Systems. “The ability to access objects and their attributes from either the model or the 2D drawings without leaving Assemble is a huge benefit and shows how Assemble is focusing on interoperability across systems and project teams.” AEC professionals can get a look at the integration in an upcoming Assemble webinar on December 15, 2016 at 1pm Central. About Assemble Systems Headquartered in Houston, TX, Assemble Systems provides construction data management solutions. Its core offering, Assemble Insight is a cloud based platform allowing AEC firms to leverage 3D data for increased project insight, advanced project collaboration and data driven decision making. Assemble is used today to manage over 6,500 projects. For more information about Assemble, visit http://www.assemblesystems.com.


Roland S.-B.,Assemble | Prud'homme R.E.,Assemble | Bazuin C.G.,Assemble
ACS Macro Letters | Year: 2012

Dip-coating, an important industrial technique, has been underexploited for preparing block copolymer (BC) thin films, such that the knowledge regarding their general characteristics is limited. Here, we present an overview of the crucial factors that determine how BC film morphology evolves as a function of dip-coating rate (withdrawal speed) over a wide range, illustrated using THF solutions of a polystyreneb- poly(4-vinyl pyridine) (PS-P4VP) diblock copolymer mixed with two small molecules, naphthol and naphthoic acid, which are hydrogen-bonders with P4VP. Key factors in determining the film morphology are the systematic variation in film thickness and, for supramolecular BCs, in film composition with dip-coating rate. The former shows a general V-shaped dependence, related to the so-called capillarity and draining regimes identified previously for dip-coated sol-gel films. The relative small molecule content in the films studied is shown to increase in the capillarity regime from low to that of the dip-coating solution and thereafter to remain constant. Together, these changes, in addition to solvent and other effects, determine the film morphology and its evolution with dip-coating rate. © 2012 American Chemical Society.


Zhang H.,Shenyang Ligong University | Lin Z.,Assemble | Xing J.,Shenyang Ligong University
Journal of Theoretical and Applied Information Technology | Year: 2013

This paper introduces the principle of thermal analysis for the combustion engine piston, gets the heat exchange coefficient of the piston top and the heat exchange coefficient distribution of the piston and the cooling water through calculation, calculates the temperature field of the piston with the finite element method and modifies the calculation model by repeatedly comparing the result with the measured temperature. It is found out that the temperatures of the piston top and the first circular groove are relatively high after calculating the temperature field and based on the results the optimization scheme of adding the cooling oil chamber is applied to the piston structure. Results show that, after optimization, the maximum temperature of the piston top is decreased to 264, and the temperature at the first ring is decreased to 204, thus improving the working condition of the piston ring. © 2005 - 2013 JATIT & LLS. All rights reserved.


Zhang H.,Shenyang Ligong University | Lin Z.,Assemble | Xu D.,Shenyang Ligong University
Journal of Theoretical and Applied Information Technology | Year: 2013

With the definite-element analysis software, a three-dimensional definite-element analysis has been carried out to the gasoline engine piston. Considering the thermal boundary condition, the stress and the deformation distribution conditions of the piston under the coupling effect of the thermal load and explosion pressure have been calculated, thus providing reference for design improvement. Results show that, the main cause of the piston safety, the piston deformation and the great stress is the temperature, so it is feasible to further decrease the piston temperature with structure optimization. © 2005 - 2013 JATIT & LLS. All rights reserved.


Stare at your computer all day? These apps might help!June 30Just about everyone who runs a successful start up or small business spends a lot of time in front of their computer, tablet or phone. After a while, you might feel like your eyes are going a little bonkers ...


A method and apparatus for managing a building model inventory, including a database structured for storing element specification and instance data from both a previous version and a latter revision of building information modeling datasets, respectively. In addition to the building information modeling element data, the database associates completed assembly pass, unit cost, work breakdown structure, and other inventory management data with the element type definitions and element instance data. Application software compares the first and second inventory revisions to identify all changes, additions and/or deletions of building elements between the previous version and the latter revision of the building information modeling datasets. By tracking the elements that change, the changes that affect the construction schedule and quantity, configuration and specification of materials are identified. An engineering cost analysis based on the changed data provides a rapid understanding of the implications of any design change.


Patent
Assemble | Date: 2013-12-13

Techniques (systems and methods and their embodiment in computer readable media) are disclosed for providing multiple parties a common view, and joint-control of that common view, into a high-fidelity model. Illustrative embodiments are described in the context of building information modeling systems, although the disclosed concepts are not so limited.

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