Silchar, India
Silchar, India

Assam University is a teaching-cum-affiliating university. The university has sixteen schools which offer Social science, Humanities, Languages, Life science, Physical science, Environmental science, Information science, Technology and Management Studies. There are 35 departments under these sixteen schools. The five districts under the jurisdiction of Assam University have 56 undergraduate colleges. Assam University is an institutional signatory to the Global Universities Network for Innovation , Barcelona and United Nations Global Compact for its commitment to educational social responsibilities.The main campus, in an area of 600 acres , is located at Dargakona, about 20 km from Silchar, while a second campus of the university is at Diphu, in the Karbi Anglong district. Wikipedia.

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Shil S.,Assam University | Dutta Choudhury M.,Assam University | Das S.,Assam University
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance Traditional remedies used for the treatment of various ailments are considered to be very important in the primary health care of Reang people living in Tripura state of Northeast India. Novel information gathered from the present investigation is important in preserving folk indigenous knowledge of Reang tribe. Methods Systematic and exhaustive field surveys were conducted during 2003 to 2004 in Reang inhabited areas of Tripura state of Northeast India covering all the seasons, to gather information on medicinal herbs used by them in the treatment of various ailments. Information was collected from 55 traditional herbalists of different age through structured questionnaires and personal observations made during the field visit. The data obtained was analyzed through informant consensus factor (FIC) to determine the homogeneity of informant's knowledge on medicinal plants also the fidelity level (FL) to authenticate the uniqueness of a species to treat a particular ailment. Results In the present study a total of 125 medicinal plants species belonging to 116 genera and 59 families were presented, used for treating 42 different ailments. The major plant parts used are leaves and most of the remedies are suggested to take orally. The greatest parts of plants used for curing various ailments were found locally. The consensus analysis revealed that the fever and gastro-intestinal diseases have the highest informant consensus factor FIC of 0.79 followed by the dermatological problems (FIC 0.78). It is equal (FIC 0.77) for both general health problems and inflammation and pain while urinogenital problems showed relatively low levels of consensus (FIC 0.63). The level of informants' consent was high for most ailment categories indicating greater homogeneity among informants. In the present study we analyzed the disease categories to highlight some of the important plant species in terms of Fidelity level. Greater parts of the plant species achieve highest fidelity level, while only 4% acquire lower FL. The species with high citation and informant concurrence value are reasonably significant. Cyathea, a rare tree fern used for major cuts or wounds for immediate blood coagulation. Extensive local application may threaten the species if not judiciously managed. Conclusion The traditional pharmacopoeia of the Reang ethnic group incorporates a myriad of diverse flora available locally. Traditional knowledge of the remedies is passed down through oral traditions without any written document. This traditional knowledge is however, currently threatened mainly due to acculturation and deforestation. Therefore, documenting medicinal plants and associated indigenous knowledge can be used as a basis for developing management plans for conservation and sustainable use of medicinal plants of the study area. In addition, findings of this study can be used as an ethnopharmacological basis for selecting plants for future phytochemical and pharmaceutical studies. © 2014 Elsevier Ireland Ltd.

Chakraborty S.,Assam University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: The present study was carried out to identify the peptide epitopes with high immunogenicity in the surface proteins of four pathogenic Ebola virus (viz. Bundibugyo virus, Sudan virus, Tai Forest virus and Zaire Ebola virus) using modern reverse vaccinology approach through in silico analysis of proteome for use as Ebola vaccine candidates.Methods: Hexapeptide epitopes based on maximum hydrophilicity were identified in eight surface proteins which were separated from a pool of 160 Ebola virus proteins using a covariant discriminant function and the Mahalanobis D2 statistic. Heptapeptide B cell epitopes were predicted from the surface proteins using the AbDesigner algorithm. Immunogenicity score of each identified epitope was estimated on the basis of hydropathy index and Chou-Fasman conformation.Results: Four continuous (linear) hexapeptide epitopes namely RRKRRD (position 497-502), DEDDED (489-494), RRTRRE (497-502) and KTGKKG (221-226) with maximum hydrophilicity score were identified from different surface proteins for use as Ebola vaccine components. For use as B cell epitopes eight linear heptapeptide epitopes viz. PTSPPQD (418-424) and SHYEPPN (385-391) against Bundibugyo virus, PDYDDCH (309-315) and DYDDCHS (310-316) against Sudan virus, QPKCNPN (508-514) against Tai Forest virus and EYTYPDS (685-691), HLGLDDQ (365-371) and DQEKKIL (370-376) against Zaire Ebola virus with high immunogenicity were identified from different surface proteins of Ebola virus.Conclusion: Four hexapeptide and eight heptapeptide epitopes can be loaded along with T cell or B cell signal peptides in virus like particle (vlp) or formulated as subunit vaccine by pharmaceutical industry to raise humoral immunity against Ebola virus in African population as well as in other human populations across the globe as therapeutics in the same way the Hepatitis B therapeutic vaccine based on multiple peptide-epitopes was designed nearly a decade ago. © 2014, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved.

Devi H.,Assam University | Mazumder P.,Assam University
Pharmacognosy Research | Year: 2016

Introduction: With an ever increasing cause of cancer, it has been recommended to treat with conventional drugs, however because of the side effects caused by the conventional drugs, the research on medicinal plants has been intensified due to their less adverse and toxic effects. Objectives: The primary objective of the present study was to evaluate the protective effect of the medicinal plant Curcuma caesia Roxb. against free radicals ABTS + and O2 -. Also it was aimed to evaluate the protective effect of C.caesia Roxb. against the chemotherapeutic drug Cyclophosphamide and its side effects in liver and kidney. Methods: The rhizomes of the plant was extracted with methanol through soxhlet and its antioxidant activity was tested against ABTS + and O2 -. For antigenotoxic studies, animals were divided into eight groups and micronucleus assay was employed and for biochemical analysis serum sample was collected from the blood and SGOT, SGPT analysis was performed. Also the biochemical analysis was performed from both the liver and kidney. Results: The methanolic extract of Curcuma caesia Roxb. was found to scavenge the free radicals ABTS + and O2 -. the micronuclei formation was found to be increased in the positive control group as compared to the negative control group significantly (P<0.002) however increase in the number of micronuclei was found to be decrease with the pretreatment of the extract at different concentrations significantly as compared to the negative control groups (P<0.01, P<0.005,P<0.001). The increased level of serum SGPT and SGOT as well as peroxidation level in both liver and kidney due to treatment of cyclophosphamide was also found to be decreased with the pretreatment of the extract significantly as compared to the positive control groups. There was decreased in the level of endogenous antioxidant such as GSH and GR in the positive control group however decreased level of GSH and GR was found to be increased with the pretreatment of the methanolic extract of C. caesia Roxb. Conclusion: The present study suggested that the methanolic extract of C. caesia Roxb has not shown any genotoxicity and reduces the genotoxicity caused by cyclophosphamide. It was also to have the protective effects against the liver and kidney. So it could be provided as one of the herbal supplementation in chemoprevention of CP to ameliorate the side effects of it.

Chutia R.,Assam University
Applied Soft Computing Journal | Year: 2017

In this paper, a modified epsilon-deviation degree method of ranking fuzzy numbers is proposed. The epsilon-deviation degree method and other ranking methods are available in the literature and applied in the field of decision-making. Despite of the merits, some limitations and shortcomings are observed in these methods. Namely, (1) these methods cannot distinguish fuzzy numbers sharing the same support and different cores, (2) these methods cannot distinguish crisp-valued fuzzy numbers with different heights, (3) these methods also cannot make a preference between a crisp-valued fuzzy number and an arbitrary fuzzy number, (4) if the expectation values of the centroid points are the same for the fuzzy numbers to be compared, then these methods give an incorrect ranking, (5) if fuzzy numbers depict compensation of areas, then these methods fail to give a proper ranking, and (6) further inconsistency in ranking the fuzzy numbers and their images is also observed. Hence, a modified epsilon-deviation degree method is developed, based on the concept of the ill-defined magnitude ‘value’ and the angle of the fuzzy set. The proposed method bears all the properties of epsilon-deviation degree method and overcome all the limitations and shortcomings of this method and other existing methods. Various sets of fuzzy numbers are considered for comparative study between the existing ranking methods and the proposed method for validation. Further, the proposed method seems to outperform in all situations. Risk analysis problem under uncertain environment are often studied under fuzzy domain. Hence, a study is done by applying the proposed method to risk analysis in poultry farming. © 2017 Elsevier B.V.

News Article | November 8, 2016

NAPLES, ITALY, November 08, 2016-- Dr. Giulio Tarro has been included in Marquis Who's Who. As in all Marquis Who's Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in a field are all taken into account during the selection process.Beginning in 1966, Dr. Tarro's illustrious 50-year career has been comprised of notable achievements in virology, microbiology, and immunology. After earning an MD from the University of Naples Federico II, Dr. Tarro became an assistant in medical pathology at his alma mater. He then became a research fellow at the National Research Council, and by the fellowship's end, he was an assistant professor of research pediatrics and a research associate in the division of virology and cancer research at the University of Cincinnati College's Medicine and Children's Hospital. Further, he taught oncologic virology and microbiology and immunology at the University of Naples Federico II's College of Medicine and School of Specialization and was the chief of the virology division at D. Cotugno Hospital Infectious Diseases. Dr. Tarro had also obtained a postgraduate degree in nervous diseases and a Ph.D. in virology. He went on to become the research chief for the National Research Council.Dr. Tarro's academic and professional achievements continued to overlap as the decades passed, with each accomplishment earning the virologist more national and international recognition than the last. Following his Ph.D., Dr. Tarro earned a postgraduate degree in medical and biological sciences from Roman Academy, an honorary degree in medicine from Pro-Deo State University, an honorary degree in immunology from St. Theodora Academy, an honorary degree in bioethics from Constantinian University, an honorary Master of Science in biomedical technology from Assam University, and an honorary degree in social sciences from Bonakè University. At the same time, he became the president of the ethic committee and the head of the diagnostic laboratories in the department of infectious diseases at D. Cotugno Hospital. At last, in 2006, he retired.Prior to Dr. Tarro's retirement, he held an abundance of career-related positions. He was on the National Committee on Health and was the science coordinator of extracorporeal hyperthermia in HCV patients at First Circle Medical. To remain abreast of industry advancements, Dr. Tarro maintained affiliations with the International League of Doctors against Vivisection, the Italian Society Immuno-Oncology, and the American Association for Cancer Research.For his remarkable accomplishments, Dr. Tarro has been featured in the 32nd through 37th editions of Who's Who in Finance and Business, the 48th through 70th editions of Who's Who in America, the 1st through 8th editions of Who's Who in Medicine and Healthcare, the 1st through 12th editions of Who's Who in Science and Engineering, and the 10th through 33rd editions of Who's Who in the World.About Marquis Who's Who :Since 1899, when A. N. Marquis printed the First Edition of Who's Who in America , Marquis Who's Who has chronicled the lives of the most accomplished individuals and innovators from every significant field of endeavor, including politics, business, medicine, law, education, art, religion and entertainment. Today, Who's Who in America remains an essential biographical source for thousands of researchers, journalists, librarians and executive search firms around the world. Marquis now publishes many Who's Who titles, including Who's Who in America , Who's Who in the World , Who's Who in American Law , Who's Who in Medicine and Healthcare , Who's Who in Science and Engineering , and Who's Who in Asia . Marquis publications may be visited at the official Marquis Who's Who website at

Nanocellulose is an emerging sustainable biomaterial with exceptional physicochemical properties. It can be isolated from inexpensive renewable cellulosic biomass and a number of natural plant fibers have been extensively investigated as a source for such isolation. The geometrical dimensions of the prepared cellulose nanocrystals (CNCs) are however, found to vary widely, depending on the source of the cellulosic material and hydrolysis conditions. CNCs are biocompatible and biodegradable which exhibit very low cytotoxicity thus, offering a wide range of opportunities for biomedical applications. By surface modification of nanocellulose, various functional materials with tunable properties can also be developed. Over the past two decades, CNCs have garnered a significant interest as biobased reinforcing nanofiller material. This mini review will provide an overview into the production methods, sources of cellulosic fibers, surface modification strategies and drug delivery applications of the chemically or mechanically isolated nanocellulose. © 2015 Bentham Science Publishers.

Mondal R.,Assam University | Ghosh S.K.,Assam University
Mitochondrial DNA | Year: 2013

Northeast India has one of the world's highest incidences of oral cancer and 90% of them are related to tobacco. We examined the complete mitochondrial genome to determine hot spot mutations in oral cancer. The complete mitochondrial genome was sequenced using PGM™ from 10 patients matched blood and tumour tissue. Overall, 26 somatic mutations were found of which nine mutations in d-loop and 17 mutations in the coding region. The mutations at nucleotide positions 16294, 16325 and 16463 in d-loop and 4136, 13542 and 13869 in coding region are probably an indication to be a hot spot mutation in oral cancer. The knowledge about role, patterns and timing of mitochondrial mutations may serve to be facilitating clinical applications and hot spot mutations may be helpful in assessing cancer risk in tumour. © 2013 Informa UK, Ltd.

Ghosh S.K.,Assam University
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2010

A comparative study has been made on the synthetic strategy, particle morphology and surface charge of the aqueous dispersion gold nanoparticles stabilized electrostatically by 4-(dimethylamino)pyridine (DMAP) and trisodium citrate. The information from UV-vis spectroscopy, transmission electron microscopy and zeta potential measurements substantiated the result. To explore the real-time applications of these two interesting systems, solubility and stability of these two types of stabilized particles and the nature and extent of the interaction of the stabilizing ligand shell with the surface of gold nanoparticles have been elucidated. The size regime dependence of the citrate-stabilized particles has been rationalized in view of the dependence of surface area on the size of the particles. © 2010 Elsevier B.V.

Duarah C.,Gauhati University | Das A.,Assam University | Singh N.N.,Gauhati University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012

Bimaximal (BM) and tri-bimaximal (TB) mixings of neutrinos are two special cases of lepton mixing matrix, which predict the reactor angle θ 13=0 and the atmospheric angle tan 2θ 23=1. Recent precision measurements and global analysis of oscillation parameters, have confirmed a non-vanishing value of θ 13 as well as deviations of θ 12 and θ 23 from their maximal values predicted by BM or TB mixing. In this work we mainly concentrate on θ 13 and θ 23 to assign θ 13≠0 and tan 2θ 23<1 with the help of charged lepton corrections defined by UPMNS=Ul†Uν. We first consider U ν to be given separately by BM and TB mixing matrices and then find the possible forms of U l such that the elements of PMNS matrix, finally yield θ 13≠0 and tan 2θ 23<1 in agreement with latest observational data. To compute the values of mixing angles we assume the charged lepton correction to be of Cabibbo-Kobayashi-Maskawa (CKM) like. All the mixing matrices involved in the calculation satisfy the unitarity condition to leading order of expansion parameter. We also analyze both the mixing schemes in presence of Dirac CP phase and find expressions for the rephasing invariant quantity J CP which have been discussed in recent literature. © 2012 Elsevier B.V.

Hydrophobic photoluminescent carbon nanodots (CNDs) were fabricated by using citric acid and L-tyrosine precursor molecules through a simple, facile thermal oxidation process in air. These CNDs (less than 4 nm in size) exhibited a characteristic excitation wavelength dependent emission and upconversion emission properties and are insoluble in water, but soluble in organic solvents. FTIR and 1H NMR analyses showed a selective participation of L-tyrosine molecule during the carbonization process at 220 oC without a disturbance of its benzylic protons and aromatic phenyl ring bearing hydroxy group. TEM and XRD studies revealed a quasi-spherical morphology and poor-crystalline nature of CNDs. Because the presence of the hydroxy group of L-tyrosine is dominating at the surface, these CNDs are also soluble in water under basic conditions. The effects of base and silver nanoparticles on the luminescence properties of CNDs were studied and a quenching of fluorescence was observed. These tyrosine-passivated CNDs are applicable for both biologically and commercially. © 2014 Gude.

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