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Fridin M.,Ariel University | Belokopytov M.,Assaf Harofeh Medical Center
Computers in Human Behavior | Year: 2014

This study examined the first-time acceptance of (SAR) by preschool and primary school teachers. A modified Unified Theory of Acceptance and the Use of Technology model was applied using the questionnaires filled out by 18 teachers following interactions with a robot. The participants demonstrated positive reactions and acceptance accompanied by a variety of answers. The lack of consolidated views in the tested population of teachers and the need for an adaptation of the model are suggested. The future intensive research of teacher-acceptance of SAR will avoid the gap between technology and the end-user. © 2013 Elsevier Ltd. All rights reserved. Source

Or L.,Assaf Harofeh Medical Center
Ophthalmic Plastic and Reconstructive Surgery | Year: 2016

PURPOSE:: The purpose of this study is to describe a new complication of a xanthelasma-like reaction which appeared after dermal filler injection in the lower eyelid region. METHODS:: A retrospective case analysis was performed on 7 patients presenting with xanthelasma-like reaction after filler injection to the lower eyelids. RESULTS:: Seven female subjects with no history of xanthelasma presented with xanthelasma-like reaction in the lower eyelids post filler injection. Fillers included hyaluronic acid (2 patients), synthetic calcium hydroxyapatite (4 patients), and polycaprolactone microspheres (one patient). Average time interval between filler injection and development of xanthelasma-like reaction was 12 months (range: 6–18 months). Treatment included steroid injections, 5FU injections, ablative or fractionated CO2 laser, and direct excision. Pathology confirmed the lesion was a true xanthelasma in one patient. In treated patients, there was subtotal resolution after laser. Xanthelasma-like reaction resolved completely after direct excision. Three patients elected to have no treatment. CONCLUSIONS:: Previously there has been one reported case of xanthelasma after filler injection. This case series is the largest to date. Furthermore, this series is notable because xanthelasma-like reactions appeared after injection with 3 different types of fillers. None of the patients had evidence of xanthelasma prefiller injection. The precise mechanism by which filler injection can lead to the formation of xanthelasma-like reaction is unclear. A possible mechanism may be related to binding of low-density lipoprotein and internalization by macrophages. Further investigation is required. Nevertheless, physicians performing filler injections should be aware of this new complication and treatment options. © 2016 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved. Source

Rabin I.,Assaf Harofeh Medical Center
The Israel Medical Association journal : IMAJ | Year: 2011

Gastric stump cancer is often described as a tumor with a poor prognosis and low resectability rates. To compare the pathological characteristics of gastric stump cancer patients with those of patients with proximal gastric cancer. This retrospective study was based on the demographic and pathological data of patients diagnosed with gastric cancer and treated at Assaf Harofeh Medical Center during an 11 year period. The patients were divided into two groups: those undergoing proximal gastrectomy for proximal gastric cancer and those undergoing total gastrectomy for gastric stump cancer. Patients with gastric stump cancer were predominantly male, older (P = 0.202, not significant), and had a lower T stage with less signet-ring type histology, fewer harvested and fewer involved lymph nodes (P = 0.03, statistically significant) and less vascular/lymphatic involvement than patients with proximal gastric cancer. The lower incidence of involved lymph nodes and lymphovascular invasion in gastric stump cancer as compared to proximal gastric cancer in this study may imply that the prognosis of gastric stump cancer may be better than that of proximal gastric cancer. However, to verify this assumption a study comparing patient survival is required. Source

Nasser C.K.,Assaf Harofeh Medical Center
Journal of refractive surgery (Thorofare, N.J. : 1995) | Year: 2012

To assess measurement repeatability of corneal curvature, minimal corneal thickness, and anterior chamber depth obtained with the Sirius imaging system (Costruzioni Strumenti Oftalmici) and to assess its agreement with the Pentacam HR imaging system (Oculus Optikgeräte GmbH). Healthy individuals were prospectively recruited. To assess repeatability, eight consecutive measurements were performed in the right eye of healthy individuals with the Sirius. A single measurement was then performed consecutively with both systems. The anterior and posterior corneal radii (antR and posR, respectively), anterior chamber depth, and minimal corneal thickness were evaluated. Repeatability of Sirius was evaluated by calculating coefficients of variation (CoV). Agreement between Sirius and Pentacam was assessed by calculating 95% limits of agreement (LoA) and plotting Bland-Altman graphs. Forty-five eyes from individuals (21 men, 24 women) aged 20 to 61 years were evaluated. The mean CoV was 0.37% and 1.32% for antR and posR at 3 mm, respectively, and 0.36% and 1.28% for antR and posR at 7 mm, respectively. For anterior chamber depth and minimal corneal thickness, the CoV was 0.56% and 1.69%, respectively. Calculated 95% LoA were -0.1 to 0.12 mm (mean difference: 0.018 mm) and -0.54 to 0.33 mm (mean difference: 0.1 mm) for antR and posR at 3 mm, respectively. For anterior chamber depth, 95% LoA was -0.23 to 0.09 mm (mean difference: 0.068 mm) and -9.61 to 33.44 μm (mean difference: 11.91 μm) for minimal corneal thickness. The Sirius showed good to excellent repeatability for all measured parameters. Agreement analysis suggests that Sirius and Pentacam should not be used interchangeably. Copyright 2012, SLACK Incorporated. Source

Ahmed Z.,University College London | Algom A.A.,Assaf Harofeh Medical Center | Tsuboi Y.,Fukuoka University | Josephs K.A.,Mayo Medical School
Current Opinion in Neurology | Year: 2010

Purpose of review: Neurodegenerative tauopathies, of which progressive supranuclear palsy (PSP) is one of the most common, are clinically heterogeneous, reflecting differences in distribution and biochemical composition of tau pathology. This review highlights the range of clinical and pathologic presentations of PSP and its variants. Recent findings: Progressive supranuclear palsy is a 4R tauopathy with neuronal and glial tau-immunoreactive lesions in neuroanatomically specific nuclei in the basal ganglia, diencephalon, brainstem and cerebellum, with restricted involvement of the neocortex. Hierarchical cluster analyses of clinical and pathologic features of PSP indicate that there are distinct clinicopathologic variants of PSP. In variants of PSP presenting with focal cortical syndromes, such as frontotemporal dementia, corticobasal syndrome and apraxia of speech, there is greater cortical pathology than in typical PSP. In variants of PSP presenting with levodopa-responsive Parkinsonism, as well as pure akinesia and gait failure, there is less cortical pathology and more severe degeneration in the cardinal nuclei-globus pallidus, subthalamic nucleus and substantia nigra-than in typical PSP. Summary: Clinical variants in PSP reflect varying anatomical distribution of tau pathology, but they share histopathologic, biochemical and genetic features with typical PSP. The basis for anatomical selective vulnerability in PSP and its variants remains to be determined. © 2010 Wolters Kluwer Health | Lippincott Williams and Wilkins. Source

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