Bang Lamung, Thailand
Bang Lamung, Thailand

Asian University , formerly Asian University of Science and Technology and founded in 1993, initially with the academic co-operation of Imperial college in London is an international university using English as the medium of instruction for all programs and is located in Chonburi, Thailand, about 25 km from Pattaya. Wikipedia.

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Yeh T.F.,Childrens Hospital and | Chen C.M.,Taipei Medical University | Chen C.M.,Taipei Medical University Hospital | Wu S.Y.,University of Illinois at Chicago | And 5 more authors.
American journal of respiratory and critical care medicine | Year: 2016

RATIONALE: Bronchopulmonary dysplasia (BPD) is an important complication of mechanical ventilation in preterm infants, and no definite therapy can eliminate this complication. Pulmonary inflammation plays a crucial role in its pathogenesis, and glucocorticoid is one potential therapy to prevent BPD.OBJECTIVES: To compare the effect of intratracheal administration of surfactant/budesonide with that of surfactant alone on the incidence of death or BPD.METHODS: A clinical trial was conducted in three tertiary neonatal centers in the United States and Taiwan, in which 265 very-low-birth-weight infants with severe respiratory distress syndrome who required mechanical ventilation and inspired oxygen (fraction of inspired oxygen, ≥50%) within 4 hours of birth were randomly assigned to one of two groups (131 intervention and 134 control). The intervention infants received surfactant (100 mg/kg) and budesonide (0.25 mg/kg), and the control infants received surfactant only (100 mg/kg), until each infant required inspired O2 at less than 30% or was extubated.MEASUREMENTS AND MAIN RESULTS: The intervention group had a significantly lower incidence of BPD or death (55 of 131 [42.0%] vs. 89 of 134 [66%]; risk ratio, 0.58; 95% confidence interval, 0.44-0.77; P < 0.001; number needed to treat, 4.1; 95% confidence interval, 2.8-7.8). The intervention group required significantly fewer doses of surfactant than did the control group. The intervention group had significantly lower interleukin levels (IL-1, IL-6, IL-8) in tracheal aspirates at 12 hours and lower IL-8 at 3-5 and 7-8 days.CONCLUSIONS: In very-low-birth-weight infants with severe respiratory distress syndrome, intratracheal administration of surfactant/budesonide compared with surfactant alone significantly decreased the incidence of BPD or death without immediate adverse effect. Clinical trial registered with (NCT-00883532).

Silapunt R.,King Mongkut's University of Technology Thonburi | Torrungrueng D.,Asian University
Progress in Electromagnetics Research | Year: 2011

Conjugately characteristic-impedance transmission lines (CCITLs) are a class of transmission lines possessing conjugately characteristic impedances (Z±0) for waves propagating in the opposite direction. A typical Z0 uniform transmission line is a special case of CCITLs whose argument of Z±0 is equal to 0°. This paper aims to generalize the CCITL system by demonstrating a theoretical study of CCITLs and their applications in the microwave transistor amplifier design. It is found that the bilinear transformation plays an important role in transforming circles in the reflection coefficient g{cyrillic}0-plane in the Z0 system to the g{cyrillic}-plane in the CCITL system. In addition, Meta- Smith charts, a graphical tool developed for solving problems in the CCITL system, are employed to design matching networks to achieve desired amplifier properties. Results show that stability regions on Meta-Smith charts can be determined, and source and load reflection coefficients can be selected properly to obtain desired operating power gain. In addition, an example shows that Meta-Smith charts offer a simple approach for matching network design using open-circuited single-stub shunt tuners.

Ma P.,State University of New York at Stony Brook | Wang L.-S.,State University of New York at Stony Brook | Guo N.,Asian University
Applied Energy | Year: 2014

A case is made that while it is important to mitigate dissipative losses associated with heat dissipation and mechanical/electrical resistance for engineering efficiency gain, the "architect" of energy efficiency is the conception of best heat extraction frameworks-which determine the realm of possible efficiency. This precept is applied to building energy efficiency here. Following a proposed process assumption-based design method, which was used for determining the required thermal qualities of building thermal autonomy, this paper continues this line of investigation and applies heat extraction approach investigating the extent of building partial homeostasis and the possibility of full homeostasis by using cooling tower in one summer in seven selected U.S. cities. Cooling tower heat extraction is applied parametrically to hydronically activated radiant-surfaces model-buildings. Instead of sizing equipment as a function of design peak hourly temperature as it is done in heat balance design-approach of selecting HVAC equipment, it is shown that the conditions of using cooling tower depend on both "design-peak" daily-mean temperature and the distribution of diurnal range in hourly temperature (i.e., diurnal temperature amplitude). Our study indicates that homeostatic building with natural cooling (by cooling tower alone) is possible only in locations of special meso-scale climatic condition such as Sacramento, CA. In other locations the use of cooling tower alone can only achieve homeostasis partially. © 2014 Elsevier Ltd.

Ma P.,State University of New York at Stony Brook | Wang L.-S.,State University of New York at Stony Brook | Guo N.,Asian University
Applied Energy | Year: 2015

In two earlier papers we proposed a process assumption- based design method, one aim of which is the determination of the thermal requirement of a building by investigating the building functioning as a dynamic thermal system. The principal constraint of that determination is the building indoor temperature range to be no more than 2. °C. In this paper we focus on the thermal requirement of maximum WWR (window-to-wall ratio) allowed by the constraint as a function of envelope U-value and ambient temperature amplitude. Seven US cities are studied to represent a range of ambient temperature amplitudes. As the window part of a building's envelope is a prominent architectural feature of the building, WWR and its allowed maximum in terms of thermal autonomy are the signature/reflection of local ambient temperature amplitude and the variety of envelopes of building stock in each locality. Such signal characteristics are otherwise referred to as regional architecture. © 2015 Elsevier Ltd.

Ma P.,State University of New York at Stony Brook | Wang L.-S.,State University of New York at Stony Brook | Guo N.,Asian University
Applied Energy | Year: 2013

Since Willis Carrier's invention of air conditioning in 1911, we traditionally think about building conditioning in terms of the heating and cooling of a building's indoor air. A better idea is the heating and cooling of a building's mass. The latter has been called the radiant method, of which a most attractive strain is the thermally activated building systems (TABS) proposed by Robert Meierhans in 1990s. In this paper, a resistor-capacitor (RC) model is built in Matlab/Simulink for studying the system requirement of a TABS-equipped building-room. Specifically, what is the requirement in the envelope thermal resistance and activated TABS thermal mass of the room so that it is able to keep the room's indoor operative temperature within the comfort range with its surroundings at neutral mean ambient temperature? Systematic simulations show that at neutral ambient temperature, the room's manageability requires the correct selection of thermal mass at normal value and thermal resistance within minimum envelope resistance range (MERR). With its surroundings at above neutral ambient temperature, the room with the required mass-envelope combination functions robustly, albeit with a slightly larger operative temperature variation. We introduce the term thermally manageable building, defined as buildings that can be managed with off-peak equipment, either mechanical equipment (e.g., a chiller) or (natural energy gradient driven) low-power equipment (e.g., a cooling tower). Simulation results also show that while the mean operative temperature level is maintained by cooling equipment (mechanical or low-power one), the operative temperature variation is primarily a function of a building's thermal mass and a building's envelope thermal resistance and, only to a small extent, a weak function of mean ambient temperature and the diurnal temperature amplitude. © 2012 Elsevier Ltd.

Chang C.-J.,University of Houston | Chao C.-H.,University of Houston | Xia W.,University of Houston | Yang J.-Y.,University of Houston | And 14 more authors.
Nature Cell Biology | Year: 2011

The epithelialg-mesenchymal transition (EMT) has recently been linked to stem cell phenotype. However, the molecular mechanism underlying EMT and regulation of stemness remains elusive. Here, using genomic approaches, we show that tumour suppressor p53 has a role in regulating both EMT and EMT-associated stem cell properties through transcriptional activation of the microRNA miR-200c. p53 transactivates miR-200c through direct binding to the miR-200c promoter. Loss of p53 in mammary epithelial cells leads to decreased expression of miR-200c and activates the EMT programme, accompanied by an increased mammary stem cell population. Re-expressing miR-200c suppresses genes that mediate EMT and stemness properties and thereby reverts the mesenchymal and stem-cell-like phenotype caused by loss of p53 to a differentiated epithelial cell phenotype. Furthermore, loss of p53 correlates with a decrease in the level of miR-200c, but an increase in the expression of EMT and stemness markers, and development of a high tumour grade in a cohort of breast tumours. This study elucidates a role for p53 in regulating EMT-MET (mesenchymal-epithelial transition) and stemness or differentiation plasticity, and reveals a potential therapeutic implication to suppress EMT-associated cancer stem cells through activation of the p53-miR-200c pathway. © 2011 Macmillan Publishers Limited. All rights reserved.

Shankar S.,RMIT University | Jaiswal L.,RMIT University | Aparna R.S.L.,Asian University | Prasad R.G.S.V.,Asian University
Materials Letters | Year: 2014

A cost-effective and eco-friendly method has been developed to form colloidal solutions of gold (AuNPs), silver (AgNPs), and gold-silver-alloy (Au-Ag-NPs) nanoparticles using Lansium domesticum (LD) fruit peel extract as a combined reducing and capping agent for the first time. The synthesized nanoparticles were characterized by various physic-chemical techniques. AgNPs and Au-Ag-NPs demonstrated potential antimicrobial activity. All these nanoparticles showed significant biocompatibility on C2C12 cell line. In addition, cellular and LDH activities supported our biocompatibility results. The outcomes of this study indicate that, these nanoparticles could be effectively utilized in pharmaceutical, biotechnological and biomedical applications. © 2014 Elsevier B.V.

Fox A.G.,Asian University
ASM Proceedings of the International Conference: Trends in Welding Research | Year: 2013

This paper describes a comparative study on the effect of additions of individual amounts of aluminium and titanium to C-Mn steel weld metal and the implications of these additions for weld-metal microstructures and mechanical properties. The experiments involved the evaluation of the metallic component of the weld metal microstructures by optical microscopy and the determination of the overall chemistries and phases present in the non-metallic inclusions in the weld metals by analytical TEM. The inclusion size distributions and volume fractions were also determined by SEM. Inclusions in essentially micro-alloy free weld metals, containing less than 6 ppmw of both Al and Ti, were found to contain small (less than 4.0 wt. %) amounts of Mn(Cu)S and manganese silicates in both glassy and crystalline forms with no Ti oxides and traces of Al 2O3; these inclusions nucleated only about 12% acicular ferrite. Additions of Ti to similar weld metals, containing less than 6 ppmw Al, reduced the sulphide contents of the inclusions and the manganese silicates were initially partially replaced with Mn.Ti2O4 (28 and 120 ppmw Ti) and subsequently with predominant proportions of TiO (410 ppmw Ti). These weld metals contained useful amounts of acicular ferrite (AF) (from 58 to 72%) and had improved strengths and notch toughness. In contrast, additions of Al proved less effective at increasing AF content. Indeed, it wasn't increased significantly until about 250 ppmw Al or more was present in the weld metal so that γ-Al2O3 was formed in the inclusions. In this case between 17 and 22% acicular ferrite was nucleated with some increase in strength and toughness. Copyright © 2013 ASM International® All rights reserved.

Busapathumrong P.,Asian University
Journal of Social Work in Disability and Rehabilitation | Year: 2013

This project explores disaster management in Thailand with a focus on the vulnerability and resilience of women, children, the elderly, and the disabled population and on the impact of disaster on these subpopulations. The 2 main findings deal with the major models of disaster management in Thailand and building resilience for social recovery. The selected 5 major models currently employed in disaster management in Thailand are the (a) model of royal project and international cooperation on disaster preparedness and response, (b) ASEAN Socio-Cultural Blueprint, (c) rights-based approach, (d) welfare mix model, and (e) knowledge management model. © 2013 Copyright Taylor and Francis Group, LLC.

Hawes T.C.,Asian University
Cryo letters | Year: 2014

At temperatures below their temperature of crystallization (Tc), the extracellular body fluids of insects undergo a phase transition from liquid to solid. Insects that survive the transition to equilibrium (complete freezing of the body fluids) are designated as freeze tolerant. Although this phenomenon has been reported and described in many Insecta, current nomenclature and theory does not clearly delineate between the process of transition (freezing) and the final solid phase itself (the frozen state). Thus freeze tolerant insects are currently, by convention, described in terms of the temperature at which the crystallization of their body fluids is initiated, Tc. In fact, the correct descriptor for insects that tolerate freezing is the temperature of equilibrium freezing, Tef. The process of freezing is itself a separate physical event with unique physiological stresses that are associated with ice growth. Correspondingly there are a number of insects whose physiological cryo-limits are very specifically delineated by this transitional envelope. The distinction also has considerable significance for our understanding of insect cryobiology: firstly, because the ability to manage endogenous ice growth is a fundamental segregator of cryotype; and secondly, because our understanding of internal ice management is still largely nascent.

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