Neal E.,Asian Medical Institute
Medical Acupuncture | Year: 2015
The practice of physician acupuncture faces unique challenges in its development and inclusion as a recognized medical specialty. Information contained in early Chinese medical texts offers solutions to some of the divides that separate Chinese Medicine from contemporary biomedicine. Recent advances in classical text research - made possible by the establishment of Chinese language databases - provide new hypotheses of disease pathogenesis and new strategies for treating various acute and chronic illnesses. The Vascular Model of Disease Pathogenesis summarizes some theories of early Chinese medicine into language recognizable by modern science. This theory bridges some of the current disparities between ancient and modern practices and offers a new model of human health, illness, and clinical therapeutics. © Mary Ann Liebert, Inc. 2015.
Agarwal J.,Asian Medical Institute
Indian Journal of Pediatrics | Year: 2013
The lack of information about management of chronic constipation in children amidst general physicians has necessitated this review. A literature search in PubMed was conducted with regard to epidemiology, clinical features, investigation and management of chronic constipation in children. English language studies published over the last 20 y were considered and relevant information was extracted. Constipation is a common problem among children; the commonest cause is functional (95 %). An elaborate history and thorough physical examination are only essential things required to make a diagnosis of functional constipation. Management consists of disimpaction, followed by maintenance therapy with oral laxative, dietary modification and toilet training. A regular follow-up with slow tapering of laxative is the must for effective treatment. Early withdrawal of laxative is the commonest cause of recurrence. © Dr. K C Chaudhuri Foundation 2013.
Randomised clinical trial: The efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis - A double-blind, placebo-controlled study
Thorat V.,Poona Hospital and Research Center |
Reddy N.,Asian Medical Institute |
Bhatia S.,Seth G S Medical College |
Rajkumar J.S.,Lifeline Multispeciality Hospital |
And 3 more authors.
Alimentary Pharmacology and Therapeutics | Year: 2012
Background Pancreatic exocrine insufficiency (PEI) results in maldigestion, leading to abdominal pain, steatorrhoea, malnutrition and weight loss. Aim To assess the efficacy and safety of pancreatin (Creon 40000 MMS) in treating PEI due to chronic pancreatitis (CP). Methods This was a 1-week, double-blind, randomised, placebo-controlled, parallel-group, multicentre study in India. Men and women ≥18 years of age with proven CP and PEI [defined as a coefficient of fat absorption (CFA) ≤80% during run-in phase] were randomised 1:1 to pancreatin or placebo (two capsules orally per main meal, one with snacks). The primary outcome measure was change in CFA from baseline to end of double-blind treatment (analysis of covariance). Results Of 62 patients randomised (34 pancreatin, 28 placebo), 61 completed treatment; one patient in the placebo arm withdrew consent before completion. Patient characteristics were similar in both groups except for the proportion of men (pancreatin 82% vs. placebo 68%). Patients receiving pancreatin had a statistically significant greater improvement in fat absorption from baseline to the end of double-blind treatment compared with those receiving placebo, with a least squares mean change (95% CI) in CFA of 18.5% (15.8-21.2) vs. 4.1% (1.0-7.2), respectively. This resulted in a treatment difference of 14.4% (10.3-18.5); P = 0.001. Patients receiving pancreatin also had a statistically significant greater improvement in nitrogen absorption and greater reductions in mean stool fat, stool frequency and stool weight compared with those receiving placebo. Treatment-emergent adverse events occurred in 12 patients on pancreatin and in seven on placebo; none led to study discontinuation. Conclusions The results provide evidence for the efficacy of pancreatin (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis, and confirm that this formulation is well tolerated, with a good safety profile, at the dose administered. © 2012 Blackwell Publishing Ltd.
Khan T.M.,King Faisal University |
Baig M.R.,Asian Medical Institute
Archives of Medical Science | Year: 2013
Introduction: The current study aims to explore the knowledge, attitude, and perception of hospital pharmacists towards HIV/AIDS and patients living with HIV/AIDS (PLWHA) in the state of Kedah, Malaysia. Material and methods: This was a cross-sectional study conducted among the hospital pharmacists in three government hospitals in Kedah, using a self-administered 43-item questionnaire. Data analysis was done using non-parametric and multinomial regression. Results: A total of 75 respondents participated in this study, resulting in a res ponse rate of 60.8%. The majority were found to be well aware of the causes of HIV/AIDS. However, about 34 (45.3%) believed erroneously that HIV/AIDS cannot be transmitted through tattooing or body piercing. Nearly 25 (33.3%) of the respondents believed that preventing the use of intravenous drugs may not be effective to prevent HIV/AIDS and endorsed social isolation as a measure to prevent HIV/AIDS. The majority (66.6%) had negative attitudes and about 20% held extremely ne - ga tive attitudes. Findings from regression modelling revealed that hospital (-2 log likelihood = 215.182, x2 = 18.060, Df = 8, p = 0.021) and gender (-2 log likelihood = 213.643, x2 = 16.521, Df = 8, p = 0.035) were more likely to affect the attitudes of respondents. Conclusions: Overall, more than one third of the respondents were found to have negative attitudes towards PLWHA. Gender, job experience, and hospitals with more HIV/AIDS patient visits were the main factors affecting attitudes.
Matsuda Z.,Asian Medical Institute
Uirusu | Year: 2013
Recent rapid developments in Asian and African countries bring an opportunity of cross-species transmission of pathogens through unprecedented contacts between people and wild animals. Furthermore, increase of global exchanges of people and products facilitates a rapid spread of infectious diseases worldwide. China has an enormous population with diverse ethnic groups within its wide territory; furthermore, it is experiencing very rapid urbanization. These conditions make China a potential epicenter of emerging infectious diseases. One good example is the SARS incidence in 2003. Therefore, it is essential to include China in a network of research groups of infectious diseases. Here we summarize the ongoing collaborations between the Institute of Medical Science, the University of Tokyo, and its Chinese counterparts.