Asian Institute of Oncology

Mumbai, India

Asian Institute of Oncology

Mumbai, India

Time filter

Source Type

Agarwal B.,University of Pennsylvania | Das P.,Children's Hospital of Philadelphia | Naresh K.N.,Hammersmith Hospital | Borges A.M.,Asian Institute of Oncology
Journal of Clinical Pathology | Year: 2011

Objectives: To study angiogenesis in metastasis of unknown primary (MUP) to support the authors'hypothesis that MUPs are of a low angiogenic phenotype and are able to undergo metastasis in spite of an unknown primary. Patients and methods: A retrospective analysis was performed on paraffin blocks obtained from 50 cases of MUP and 52 cases of metastasis of known primary (MKP) from 1 January 2000 to December 2003. A prospective analysis was performed on fresh tissues from 22 cases of MUP and 26 cases of MKP. Immunohistochemical staining for VEGF was performed on the paraffin blocks. The fresh frozen tissue was analysed by RT-PCR and Western blotting for VEGF isoforms (VEGF121, VEGF165, VEGF189) and VEGF protein, respectively. Results: Immunohistochemistry showed that MUPs had a higher percentage of lower scores of VEGF expression than MKPs. MKPs had increased scores of VEGF expression. RT-PCR analysis showed that MKPs had increased expression of VEGF121 and VEGF165 isoforms as compared with MUPs. MKPs showed a higher VEGF protein expression than MUPs. Conclusion: The study shows that metastases of squamous carcinoma from unknown primary have decreased VEGF expression at the immunohistochemical and protein level. They also display decreased expression of the VEGF121 and VEGF165 isoforms. Hence, these tumours are of a low angiogenic phenotype. They are able to develop a metastatic phenotype and grow at the metastatic site, since angiogenesis is redundant for lymph-node metastasis.


Shetty O.A.,Tata Memorial Center | Naresh K.N.,Hammersmith Hospital | Banavali S.D.,Tata Memorial Hospital | Shet T.,Tata Memorial Center | And 5 more authors.
Pediatric Blood and Cancer | Year: 2012

Background: The prevalence of human papillomavirus (HPV) infection in India is high. HPV infection is known to cause cervical cancer and has also been implicated in the pathogenesis of retinoblastoma (RB), a common intraocular malignant tumor of childhood which can be familial or sporadic. Despite the high incidence of RB in India, its familial form is rare. Hence this study was undertaken to investigate whether high-risk HPV types 16 and 18 are involved in the development of RB. Methods: Formalin fixed paraffin embedded RB tissues (n=76) including prospective cases with corresponding maternal cervical smears (n=10) were analyzed for the presence of HPV DNA sequences. Expression of the cell cycle regulatory proteins viz; p105, p107, p30, p16, E2F-1, E2F-4, and MiB-1 was studied by immunohistochemistry (IHC) (n=34). Results: A total of 53 out of 76 (69.7%) cases were positive for HPV, of these 3 cases were positive for HPV-16, 23 for HPV-18, and 27 for both HPV-16 and -18. Of the prospective cases (n=10) studied, five cases along with the corresponding maternal cervical cytology smear had identical HPV status. HPV-16 positive tumors were classified as well differentiated (P=0.013). Nuclear expression of pRB2/p130 showed significant association with HPV-16 infection (P=0.04) or dual infection of HPV-16/-18 (P=0.02). Conclusions: Our study lends support to the hypothesis that infection of HPV-16/-18 may play an important role in the development of nonfamilial form of RB in children in India. © 2011 Wiley Periodicals, Inc.


Lyerly H.K.,Duke University | Fawzy M.R.,Research Triangle Institute | Aziz Z.,Allama Iqbal Medical College | Nair R.,Tata Medical Center | And 9 more authors.
Oncologist | Year: 2015

Background. Cancer incidence and mortality is increasing in the developing world. Inequities between low-, middle-, and high-income countries affect disease burden and the infrastructure needs in response to cancer. We surveyed earlycareer oncologists attending workshops in clinical research in three countries with emerging economies about theirperception of the evolving cancer burden. Methods. A cross-sectional survey questionnaire was distributed at clinical trial concept development workshops held in Beijing, Lahore, Karachi, and Mumbai at major hospitals to acquire information regarding home-country health conditions and needs. Results. A total of 100 respondents participated in the workshops held atmajor hospitals in the region (India529, China5 25, Pakistan542, and other54). Expected consensus onmany issues (e.g., emergence of cancer as a significant health issue) was balanced with significant variation in priorities, opportunities, and challenges. Chinese respondents prioritized improvements in cancer-specific care and palliative care, Indian respondents favored improved cancer detection and advancing research in cancer care, and Pakistani respondents prioritized awareness of cancer and improvements in disease detectionandcancercare research. For all,themostfrequently cited opportunity was help in improving professional cancer education and training. Conclusion. Predominantly early-career oncologists attending clinical research workshops (in China, India, and Pakistan) identified needs for increasing clinical cancer research, professional education, and public awareness of cancer. Decision makers supporting efforts to reduce the burden of cancer worldwide will need to factor the specific needs and aspirations of health care providers in their country in prioritizing health policies and budgets. © AlphaMed Press 2015.


Sengar A.R.,Dr Bam Hospital | Kulkarni J.N.,Asian Institute of Oncology
Journal of Gynecologic Oncology | Year: 2010

A 26-year-old girl was referred to us in December 2008 with progressive pelvic mass while on chemotherapy. In May 2008, she presented with large adnexal mass and high alpha-fetoprotein (AFR 265.7 ng/mL; normal range, 0 to 10). She underwent laparoscopic right salpingo-oophorectomy with staging. Since histology was immature teratoma grade I, FIGO stage 1 she was kept on surveillance. In September 2008, she developed recurrent pelvic mass with AFP levels of 2,400 ng/mL. Three courses of chemotherapy (bleomycin-etoposide-cisplatin) were given. Post-chemotherapy AFP normalized but tumor size increased. CT-scan (abdomen-pelvis) showed a large pelvic mass with calcification specks; infiltrating the sigmoid colon and abdominal wall. With provisional diagnosis of growing teratoma syndrome she had exploratory laparotomy with excision of pelvic mass along with sigmoid colon, excision of right pelvic and subcutaneous deposits, omentectomy and sigmoid anastomosis. Left ovary, left tube and uterus appeared normal and were preserved. Histology of all masses showed mature teratoma, no immature elements. At six months follow up she is disease free and has resumed menstruation. Growing teratoma syndrome is a clinico-pathological presentation during/post-chemotherapy in malignant ovarian germ cell tumor where mature teratoma grows and requires complete surgical excision. Our case highlights the safety and adequacy concerns of laparoscopic management of malignant ovarian tumor. Literature review suggests good prospects of resumption of menses, child bearing and five year survival in case of growing teratoma syndrome.


Sengar A.R.,Dr Babasaheb Ambedkar Hospital | Tilve A.G.,Dr Babasaheb Ambedkar Hospital | Kulkarni J.N.,Asian Institute of Oncology | Bharat R.,Tata Memorial Hospital
Journal of Cancer Research and Therapeutics | Year: 2015

A 45-year-old P3L3, referred to us with abdominopelvic mass for further management. Vaginal examination was suggestive of uterine mass. Magnetic resonance imaging. (MRI) of abdomen.pelvis disclosed a uterine mass with equivocal invasion of the fat plane with the sigmoid colon. Coelomic antigen. (CA) 125 was 120.2 U/ml. (normal range, 0-35 U/ml). On exploratory laparotomy entire pelvic cavity was filled with a mass that was seen arising from the uterus and involving the sigmoid colon. Hence, a total abdominal hysterectomy with bilateral salpingo-oopphorectomy. (TAH BSO) was performed, along with resection anastomosis of the rectosigmoid and excision of omental and pelvic peritoneal nodules. Histopathology and immunohistochemical analysis, including S100-P positivity confirmed diagnosis of a malignant peripheral nerve sheath tumor. (MPNST), with tumor deposits in the right parametrium, omentum, sigmoid colon, and pelvic peritoneum. This case is presented in view of its rarity and associated diagnostic and therapeutic implications. © 2015 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.


Bushan K.,Asian Institute of Oncology Mumbai | Sharma S.,Asian Institute of Oncology | Verma H.,Asian Institute of Oncology
Indian Journal of Surgical Oncology | Year: 2013

Thymic tumors represent 0.2-1.5 % of all malignancies with an incidence of 0.15 per 100,000 population. Thymic tumors are most common tumors of the anterior mediastinum accounting for 20 % of all mediastinal tumors and 50 % of all anterior mediastinal tumors. Over 90 % of all thymic tumors occur in anterior mediastinum, remainder occurring in neck or other mediastinal areas especially aortopulmonary window and retro cardiac area which are common sites for ectopic thymic tissues and possible explanation for failure in some cases of simple thymectomy to improve Myasthenia Gravis(MG). The aim of this review is to discuss histologic classification, diagnostic features, evaluation, management and prognosis of thymic tumors. © 2013 Indian Association of Surgical Oncology.


Bushan K.,Asian Institute of Oncology | Sharma S.,Asian Institute of Oncology
Indian Journal of Cancer | Year: 2015

The aim of this article is to review randomized and non-randomized trials and meta-analysis comparing neoadjuvant chemotherapy (NAC) plus surgery versus surgery alone in resectable esophageal cancers. The article examines the value of NAC as a standard of care in the era of multimodality treatment with availability of different therapeutic options. The emphasis is on assessment of benefit of NAC in terms of survival (long and short term) rate of RO resection in resectable esophageal cancers of any histopathologic type. The in-hospital post-operative morbidity and mortality in NAC group, chemotherapeutic drug regimens and their response rates and optimal number of cycles to be used will also be addressed.


PubMed | Asian Institute of Oncology
Type: Journal Article | Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology | Year: 2016

11571 Background: Evidence suggests that breast cancer patients with ER/PR/HER2 negative disease present in a more advanced and aggressive manner. The purpose of this study was to assess the presentation trends of breast cancer patients with regards to ER/PR/HER2 status in our Indian population.We analysed retrospective data of 131 breast cancer patients presenting to our institute between January and December 2007. The patients were staged according to AJCC criteria and were divided into 3 categories: stage I/II, stage III and stage IV. ER, PR and HER2 status was then compared for the 3 categories.Of the 131 breast cancer patients, 77 (59%) presented with stage I/II disease, 45 (34%) with stage III disease and 9 (7%) with stage IV disease. 28 (36%) patients with stage I/II disease were ER/PR/HER2 negative, 11 (25%) with stage III disease were ER/PR/HER2 negative and 2 (22%) with stage IV disease were ER/PR/HER2 negative. Overall 41 (31%) patients were found to be ER/PR/HER2 negative, of which 28 (68%) belonged to stage I/II, 11 (27%) to stage III and 2 (5%) to stage IV disease.From our data we conclude that presence of ER/PR/HER2 negativity does not necessarily correlate with more advanced disease at presentation in our Indian population. No significant financial relationships to disclose.


PubMed | Asian Institute of Oncology
Type: Journal Article | Journal: Indian journal of cancer | Year: 2016

The aim of this article is to review randomized and non-randomized trials and meta-analysis comparing neoadjuvant chemotherapy (NAC) plus surgery versus surgery alone in resectable esophageal cancers. The article examines the value of NAC as a standard of care in the era of multimodality treatment with availability of different therapeutic options. The emphasis is on assessment of benefit of NAC in terms of survival (long and short term) rate of RO resection in resectable esophageal cancers of any histopathologic type. The in-hospital post-operative morbidity and mortality in NAC group, chemotherapeutic drug regimens and their response rates and optimal number of cycles to be used will also be addressed.


PubMed | SBH Government Medical College, Government Cancer Hospital and Asian Institute of Oncology
Type: | Journal: Case reports in surgery | Year: 2016

Esophageal leiomyoma is a relatively rare tumor of esophagus but it is the most common benign neoplasm of the esophagus. Small esophageal leiomyoma can be observed but larger ones and those producing symptoms should be excised. As observed for other esophageal tumors, dysphagia is its main symptom. Traditionally, open thoracotomy and enucleation are its main treatment but in the last few years video assisted thoracoscopic surgical (VATS) enucleation is gaining recognition with proven advantages of minimally invasive surgery. Herein we present our experience with patient presenting with cough rather than dysphagia as a main symptom, who was diagnosed to be having giant esophageal leiomyoma. VATS guided enucleation was accomplished successfully. Size of lesion was 16 4 3cm. Postoperative recovery was uneventful and patient is not having any signs of recurrence, after three years during follow-up period.

Loading Asian Institute of Oncology collaborators
Loading Asian Institute of Oncology collaborators