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Raval J.P.,Ashok and Rita Patel Institute of Integrated Study and Research | Akhaja T.N.,Ashok and Rita Patel Institute of Integrated Study and Research | Jaspara D.M.,Ashok and Rita Patel Institute of Integrated Study and Research | Myangar K.N.,Ashok and Rita Patel Institute of Integrated Study and Research | Patel N.H.,EMCURE Pharmaceuticals United States INC
Journal of Saudi Chemical Society | Year: 2014

In the present investigation, a series of 2(4-pyridyl)-5[(aryl/heteroarylamino)-1-oxoethyl]thio-1,3,4-oxadiazole were synthesized using isonicotinohydrazide and substituted aryl/heteroaryl amines using pyridine as solvent. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the synthesized compounds, compounds 2(4-pyridyl)-5((2-nitrophenylamino)-1-oxoethyl)thio-1,3,4-oxadiazole (5e), 2(4-pyridyl)-5((4-nitrophenylamino)-1-oxoethyl)thio-1,3,4-oxadiazole (5g) and 2(4-pyridyl)-5((2-pyrrolylamino)-1-oxoethyl)thio-1,3,4-oxadiazole (5k) produced highest efficacy and exhibited. >90% inhibition at a concentration of 0.0077, 0.0052 and 0.0089. μM, respectively. All the new compounds were pharmacologically evaluated for their in vitro Antimicrobial activity. © 2011.

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