Time filter

Source Type

Jagani C.L.,Sardar Patel University | Sojitra N.A.,Sardar Patel University | Vanparia S.F.,Sardar Patel University | Patel T.S.,Sardar Patel University | And 2 more authors.
Journal of Saudi Chemical Society | Year: 2012

The present paper describes an optimized reaction condition for the microwave promoted synthesis of newer 3-thiazole substituted 2-styryl-4(3. H)-quinazolinone derivatives, which in turn were prepared in good yield by the treatment of various 2-styryl benzoxazinone derivatives with various 2-aminothiazoles using co-solvent under microwave irradiation. All the compounds were characterized by various spectroscopic techniques and analytical methods. All newly synthesized compounds have been screened for their in vitro antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus megaterium, Bacillus subtilis, and Aspergillus niger. © 2011.


Jagani C.L.,Sardar Patel University | Sojitra N.A.,Sardar Patel University | Vanparia S.F.,Sardar Patel University | Patel T.S.,Sardar Patel University | And 2 more authors.
Arkivoc | Year: 2011

An optimization of Grimmel's method under microwave irradiation is reported here for the first time to synthesize 4-amino-N-(4-oxo-2-substituted-4H- quinazolin-3-yl)benzenesulfonamide derivatives. The method was successfully applied for the synthesis of 2-alkyl and 2-aryl substituted derivatives. However, unexpected results were obtained when the same protocol was applied for 2-styryl-substituted quinazolinones. 2-Styrylquinazolinone derivatives were then synthesized via benzoxazinones under microwave irradiation. Subsequently, the effect of various bases (e.g. Et3N, NMM, DMAP, DIPEA) on the efficiency of cyclization to quinazolinone was investigated. The use of microwave irradiation allows significant rate enhancements and better yields compared to conventional conditions. © ARKAT-USA, Inc.


Ishnava K.B.,Ashok and Rita Patel Institute of Integrated Studies | Chauhan J.B.,Ashok and Rita Patel Institute of Integrated Studies | Garg A.A.,Ashok and Rita Patel Institute of Integrated Studies | Thakkar A.M.,Ashok and Rita Patel Institute of Integrated Studies
Saudi Journal of Biological Sciences | Year: 2012

In vitro antibacterial potential of the chloroform, ethyl acetate, hexane, methanol and aqueous extracts of Calotropis gigantia (L.) R. Br. was evaluated by using five cariogenic bacteria, Actinomyces viscosus, Lactobacillus acidophilus, Lactobacillus casei, Streptococcus mitis and Streptococcus mutans. Agar well diffusion method and minimum inhibitory concentration (MIC) were used for this purpose. The chloroform extracted fraction of latex showed inhibitory effect against S. mutans and L. acidophilus with MIC value of 0.032 and 0.52. mg/mL, respectively. Qualitative investigation on structure elucidation of bioactive compound using IR, NMR and GC-MS techniques revealed the presence of methyl nonanoate, a saturated fatty acid. © 2011.

Loading Ashok and Rita Patel Institute of Integrated Studies collaborators
Loading Ashok and Rita Patel Institute of Integrated Studies collaborators