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Riverview, MI, United States

Goddard S.,Ash Stevens Inc.
Process Safety Progress | Year: 2012

Herein, we present the steps a small pharmaceutical research and development company is taking to prepare for process safety management (PSM). Although not regulated by PSM at the present time, the corporate growth plan is such that PSM will be a requirement within the next 2-5 years. When looking at the safety management systems in use by many major companies, safety personnel at small companies can become overwhelmed by the daunting task before them. Preparation is key for a small company that must use available resources efficiently in order to accomplish day to day activities. © 2012 American Institute of Chemical Engineers (AIChE). Source


Kiser E.J.,Ash Stevens Inc. | Magano J.,Pfizer | Shine R.J.,Pfizer | Chen M.H.,Wuhan Institute of Technology
Organic Process Research and Development | Year: 2012

A scalable method for the preparation of oxindole 8, a key intermediate en route to a serine palmitoyl transferase inhibitor, compound 1, is presented. A three-step, chromatography-free route has been designed that takes advantage of Buchwald's palladium-catalyzed C-H functionalization to cyclize an α-chloroacetanilide to form the five-membered ring. This process has been successfully carried out in our kilogram laboratory facility on 10-kg scale in 76% yield. © 2011 American Chemical Society. Source


Goddard S.,Ash Stevens Inc.
Global Congress on Process Safety 2012 - Topical Conference at the 2012 AIChE Spring Meeting and 8th Global Congress on Process Safety | Year: 2012

Herein we present the steps a small pharmaceutical research and development company is taking to prepare for Process Safety Management (PSM). Although not regulated by PSM at the present time, the corporate growth plan is such that PSM will be a requirement within the next 2 to 5 years. When looking at the safety management systems in use by many major companies, safety personnel at small companies can become overwhelmed by the daunting task before them. Preparation is key for a small company that must use available resources efficiently in order to accomplish day to day activities. © 2012 Ash Stevens Inc. Source


Roberts S.W.,Amgen | Shaw S.M.,Amgen | Shaw S.M.,Ash Stevens Inc. | Milne J.E.,Amgen | And 4 more authors.
Organic Process Research and Development | Year: 2012

The Ritter reaction utilizing tert-butyl acetate as the tert-butyl cation source was investigated by in situ FTIR and calorimetry under various reaction conditions. It was established that, when a batch mode reaction in acetic acid was performed, minimal isobutylene was evolved into the headspace, thereby avoiding pressurization of the reaction vessel. The safety of these conditions is due to the equilibrium of isobutylene and acetic acid with tert-butyl acetate. In addition, the observation of acetic anhydride provided insight into the role of acetic acid in the mechanistic pathway. © 2012 American Chemical Society. Source


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Trademark
Ash Stevens Inc. | Date: 2007-03-20

Chemical additives for use in the manufacture of pharmaceuticals. Chemical synthesis services for third parties.

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