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Abhā, Saudi Arabia

Shatoor A.S.,King Khalid University | Soliman H.,King Khalid University | Al-Hashem F.,King Khalid University | Gamal B.E.-.,King Khalid University | And 3 more authors.
Thrombosis Research | Year: 2012

Objective: This study was designed to investigate the possible antiplatelet effect of aqueous whole-plant C. aronia syn: Azarolus (L) extract using Wistar albino rats as a model. Materials and methods: Forty-two male albino Wistar rats weighing 200 to 250 g were divided into seven groups with six rats in each group. Group 1 served as the control and received equal volumes of distilled water. Groups 2-6 served as the experimental groups and were given C. aronia extract at doses of 100, 200, 500, 1,000, and 2,000 mg/kg, while group 7 served as a positive control and was given aspirin (25 mg/kg). All the doses were administered orally once a day and the treatment was continued for seven days. In all groups, at the end of the experimental procedure, blood samples were obtained for platelet function measurements, including PFA-100, thromboxane B2 levels, platelet count, and haematocrit. The bleeding time was determined using a modified tail cutting method described previously. Results: The aqueous C. aronia syn. Azarolus (L) extract significantly altered the bleeding time and the closure time, as determined by the PFA-100 and thromboxane B2 levels, suggesting significant platelet function inhibition. These effects were observed with C. aronia doses between 100 - 500 mg/kg, which yielded thromboxane B2 levels of 1,000 mg/kg, whereas the higher dose (2,000 mg/kg) produced opposite effects on these parameters. Conclusion: C. aronia syn. Azarolus (L) aqueous extract has antiplatelet effects in Wistar albino rats. © 2012 Elsevier Ltd. All rights reserved. Source

Al-Zaydani I.A.,Aseer Central Hospital | Joseph M.R.P.,King Khalid University | Suheel A.M.,King Khalid University | Al-Hakami A.M.,King Khalid University | Hamid M.E.,King Khalid University
Annals of Saudi Medicine | Year: 2015

Tilletiopsis minor, a blastoconidia-forming yeast, was isolated from a 4-year-old boy suffering from severe pneumonia. Chest x-rays revealed the progression of widespread and multiple nodular lesions, nonsymmetrical interstitial and airspace infiltrates, and consolidations. Creamy yellow, irregular, wrinkled yeastlike organisms were isolated from the pleural fluid specimens when cultured on Sabouraud dextrose agar for 5 days and incubated at 30°C. Microscopically, the organisms showed broad, irregular filaments with blastoconidia but no budding cells. Manual bench tests and automated phenotypic analyses failed to recognize the organism. This unique and rare organism (AB7-11; DSM 29469) was identified using the sequence analysis of the internal transcribed spacer region of the nuclear ribosomal DNA. It showed a precise alignment with the type strains of T minor. Subsequent to this diagnosis, and the earlier nonresponse to vancomycin and meropenem, the patient was put on liposomal amphotericin. However, the condition continued to deteriorate, and then, intravenous voriconazole was added to control the infection. Finally, the patient's condition improved, and he was discharged in good condition after 1 month of stay in the hospital. © 2015 Annals of Saudi Medicine. Source

Al-Amri A.M.,King College | Mirza A.G.,Aseer Central Hospital | Al-Hakami A.M.,King College
Middle East African Journal of Ophthalmology | Year: 2016

Purpose: To evaluate the safety and efficacy of tacrolimus 0.1% ointment for the treatment of refractory vernal keratoconjunctivitis (VKC). Materials and Methods: This prospective, nonrandomized case series enrolled 20 patients (40 eyes) with severe VKC, who were treated with tacrolimus 0.1% ointment. The mean age of the patients was 18.25 ± 4.2 years (range, 9-31 years). Each patient completed a follow-up period of at least 24 months. The main outcome measure was the clinical response to treatment. Results: after starting treatment with topical tacrolimus. Treatment was gradually reduced, with increasing intervals between applications. VKC recurred in all patients who attempted to discontinue treatment. No additional medications were required and no significant changes in visual acuity or refraction were documented. Five patients discontinued treatment due to a severe burning sensation and were excluded from the study. Conclusions: Tacrolimus, 0.1% ointment, is a safe and effective treatment for VKC refractory to standard treatment and may be used as a substitute for steroid treatments used to controlled disease activity. However, adverse effects could cause poor patient compliance. © 2016 Middle East African Journal of Ophthalmology. Source

Al-Binali A.M.,King Khalid University | Mahfouz A.A.,King Khalid University | Al-Fif S.,King Khalid University | Naser S.M.,Aseer Central Hospital | Al-Gelban K.S.,King Khalid University
Eastern Mediterranean Health Journal | Year: 2010

Mothers of children with bronchial asthma consecutively admitted to Aseer central hospital, Saudi Arabia (n = 171), were interviewed using a questionnaire based on the Chicago Community Asthma Survey to study their knowledge and behaviours concerning bronchial asthma. The least known information among mothers was the complications of bronchial asthma. Breathing exercises during asthma attacks were the least practised behaviour. In a multivariate analysis, significant risk factors for poor knowledge and behaviours among mothers were female sex of the child, illiterate mother and young age of mother (< 30 years). More education is needed to help the mothers of asthmatic children to acquire the necessary knowledge and practices to care for their children. Source

Bawahab M.A.,King Khalid University | Abd El Maksoud W.M.,Aseer Central Hospital | Al Amri F.S.,Aseer Central Hospital | Ali H.F.,Aseer Central Hospital | Al Salman A.N.,Aseer Central Hospital
Bahrain Medical Bulletin | Year: 2013

Background: Cholecystectomy for gallbladder stone disease is a common surgical procedure. Gallbladder carcinoma is a rare malignancy with poor prognosis, which has been linked in some studies to pre-existing gall stone disease. The current practice is to send all gallbladder specimens after cholecystectomy for histopathological examination. This adds additional workload on the pathologists. Objective: To determine the necessity of routine histopathological examination of gallbladder specimens following simple cholecystectomy. Setting: Aseer Central Hospital, Abha, Saudi Arabia. Design: Retrospective cohort study. Method: Patients who had cholecystectomy for gallstone disease from April 2010 to March 2012 were included. Operative notes, histopathological reports and final diagnoses were reviewed. Result: The study included 803 patients who had simple cholecystectomy. Three of these patients were found to have gallbladder carcinoma, two females and one male. Dense adhesions were encountered in all malignant cases necessitating conversion from laparoscopic to open cholecystectomy in one case. Macroscopic examination revealed a thickened gallbladder in all three patients; two patients had mucosal papillary lesions and one patient had polypoidal projection and mucosal ulcerations. These findings were confirmed by the pathologist. On microscopic examination, two patients had adenocarcinoma while one patient had neuroendocrine tumor. Conclusion: Selective approach for sending gallbladder specimens after cholecystectomy seems justifiable with no compromise on detection of incidental gallbladder cancer. This approach would lead to a reduction of workload on the pathologist. Source

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