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Amrutkar P.P.,Rubicon Research Pvt. Ltd. | Chaudhari S.V.,Asc College
International Journal of Pharma and Bio Sciences | Year: 2012

The objective of the present study is to develop colon targeted drug delivery system by using polysaccharide as a carrier. Matrix tablets containing various excipients and polysaccharide were prepared by wet granulation technique using different binder systems. The matrix tablets were evaluated by different IPQC tests, content uniformity, matrix index and in vitro drug release study as per IP 1996 method. Drug index profile in simulated gastric and intestinal fluid was evaluation parameter for selecting the best formulation. Drug release profile in simulated gastric, intestinal fluid from the dissolution studies was taken for selecting the best formulation. The matrix tablet containing dextrin as a carrier and ethyl cellulose as a binder found to be suitable for targeting paracetamol for local action in the colon. Same matrix tablets released fewer amounts (8-11%) of drug in simulated gastric fluid. Matrix tablets containing dextrin released 95-98 % of paracetamol in simulated colonic fluid with 4 % human fecal matter solution.


Shirole G.D.,Asc College | Shirole G.D.,Ssgm College | Kadnor V.A.,Acs College | Tambe A.S.,Asc College | Shelke S.N.,Ssgm College
Research on Chemical Intermediates | Year: 2016

Abstract: We present a facile and environmentally benign protocol for synthesis of variously substituted imidazole derivatives via multicomponent condensation of benzil, primary aromatic amine, substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehyde, and ammonium acetate in presence of 1-butyl-3-methyl-1-imidazolium tetrafluoroborate [BMIM][BF4] as catalyst under conventional reflux as well as microwave irradiation condition. The one-pot synthesis, facile solvent-free condition, and good isolated yield illustrate the utility of this green approach. The structural features are derived using analytical tools including fourier transform infrared (FTIR), Liquid chromatography-mass spectrometry (LCMS), and 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. Graphical Abstract: [Figure not available: see fulltext.] © 2016 Springer Science+Business Media Dordrecht


Patil S.R.,Asc College | Borse A.U.,North Maharashtra University | Hundiwale D.G.,North Maharashtra University
Rasayan Journal of Chemistry | Year: 2011

Density (ρ), Excess Molar volume and Apparent Molar volume are reported for binary mixtures of Ethanol, Propan-2-ol and 2-Methyl Propan-2-ol with Propan-2-amine over entire range of mole fractions at 298.15 and 308.15 K and atmospheric pressure. Excess molar volume (VE) and apparent molar volume (V+) have been calculated. These values were fitted with Redlich-Kister type polynomial equation. © 2011 RASAYAN. All rights reserved.


Shirole G.,Asc College | Kadnor V.,Ssgm College | Gaikwad S.,Ssgm College | Kshirsagar N.,Ssgm College | And 2 more authors.
Research on Chemical Intermediates | Year: 2016

Abstract: The synthesis of propargyl amine derivatives was carried out via multicomponent reaction of substituted 1,3-diphenyl pyrazole aldehyde, phenyl acetylene, and morpholine in the presence of iron oxide-supported copper oxide nanocatalyst (Nanocat-Fe-CuO) with good yields. The Nanocat-Fe-CuO was easily separated from the products and reused to catalyze the reaction again with good yield. In the absence of catalyst reaction was not proceeding to any extent. The formation of compounds was confirmed on the basis of their IR, 1H-NMR, 13C-NMR, and mass spectral techniques. Graphical Abstract: The synthesis of propargyl amine derivatives was carried out via multicomponent reaction of substituted 1,3-diphenyl pyrazole aldehyde, phenyl acetylene, and morpholine in presence of iron oxide-supported copper oxide nanocatalyst (Nanocat-Fe-CuO) with good yields. The Nanocat-Fe-CuO was easily separated from the products and reused to catalyze the reaction again with good yield. In the absence of a catalyst reaction did not proceed to any extent.[Figure not available: see fulltext.] © 2015, Springer Science+Business Media Dordrecht.


Panat A.V.,Asc College | Kulkarni D.A.,Sanjeevani Hospital | Ghooi R.B.,Cipla
Indian Journal of Human Genetics | Year: 2013

Objectives: The objective of this study is to determine the inheritance pattern of type-2 diabetes and make stratification for the general population risk. Materials and Methods: A questionnaire was developed for o btaining the family history. Analysis of the data was carried out by using student and Chi-square tests and for stratification; the guidelines of Scheuner et al. were followed. Results: The pattern of inheritance is the male sex specific (χ2 =13.44). The mean age of onset of diabetes in parents was 58.61 ± 2.94 and in offspring 46.75 ± 2.54. In all 47.22 ± 11.53% families were found in high risk and 31.94 ± 10.77% in the moderate risk category. In female diabetics, the onset was in the age range of 41-60 years. Conclusion: We found a high-risk of diabetes and familial clustering in successive generations of Brahmins with prominent male sex specificity. In females onset of diabetes was coinciding with the period around menopause.


Patil S.R.,Asc College | Deshpande U.G.,Pratap College | Hiray A.R.,Msg College
Rasayan Journal of Chemistry | Year: 2010

Viscosity(η),Density(ρ) and Ultrasonic velocities(U) are reported for binary mixtures of 1-Hexanol and 1-Heptanol with Nitrobenzene over entire range of mole fraction at 303.15 and 313.15 K and atmospheric pressure The viscosity deviation(Δη) Excess molar volume(VE) and isentropic compressibility(Ks) have been calculated. These values were fitted with Redlich-Kister type polynomial equation.


Shinde S.K.,Shivaji University | Thombare J.V.,Shivaji University | Lohar G.M.,Shivaji University | Barad D.J.,Shivaji University | And 2 more authors.
2013 International Conference on Energy Efficient Technologies for Sustainability, ICEETS 2013 | Year: 2013

Thin films of Cd0.7Fe0.3Se have been prepared on stainless steel and fluorine doped tin oxide (FTO) coated glass substrates using electrodeposition technique. Double distilled water containing precursors of Cd, Fe and Se are used with ethylene diamine tetra-acetic acid (EDTA) disodium salt as a complexing agent to obtain good quality deposits by controlling the rate of reactions. The different preparative parameters like concentration of bath, deposition time, pH of the bath and Fe content in the bath have been optimized by photoelectrochemical (PEC) technique in order to get good quality thin films. Different techniques have been used to characterize electrodeposited Cd0.7Fe0.3Se thin films. The X-ray diffraction (XRD) analysis reveals that the films Cd0.7Fe0.3Se are polycrystalline in nature with crystallite size of 282 Å for the films deposited with optimized preparative parameters. Scanning electron microscopy (SEM) study reveals that all grains uniformly distributed over the surface of stainless steel substrate indicates well defined growth of polycrystalline Cd0.7Fe0.3Se material. Optical absorption shows the direct band gap energy of 1.84 eV. Photoelectrochemical (PEC) solar cell study shows the films of Cd0.7Fe0.3Se are more photosensitive. © 2013 IEEE.


Patil L.A.,P.A. College | Pathan I.G.,Asc College
Journal of Nano- and Electronic Physics | Year: 2011

Nanocrystalline pure and CuO doped ZnO thin films were prepared using spray pyrolysis technique. The zinc nitrate (0.1 M) and copper chloride (0.1 M) were used as starting precursor. These films were characterized by XRD, SEM and EDAX to observe structural, microstructural properties and elemental analysis respectively. It is observed that the average grain size was found to decrease from 190 to 90 nm, as the doping wt % of copper chloride in zinc nitrate solution goes on increasing. The sensing performances of pure and doped films were tested. The sensitivity goes on increasing with decreases in grain size (increase of copper chloride in zinc nitate solution). The maximum sensitivity of S 35 at 400 °C was found for films prepared from 10 wt % of copper chloride. © 2011 SumDU.


Mahajan U.S.,ASC College | Godinde R.R.,ASC College | Mandhare P.N.,ASC College
Synthetic Communications | Year: 2011

Amidoximes are reduced into amidine using triethyl silane and PdCl 2 in acetic acid. Copyright © 2011 Taylor & Francis Group, LLC.


PubMed | Asc College
Type: Journal Article | Journal: Indian journal of human genetics | Year: 2013

The objective of this study is to determine the inheritance pattern of type-2 diabetes and make stratification for the general population risk.A questionnaire was developed for o btaining the family history. Analysis of the data was carried out by using student and Chi-square tests and for stratification; the guidelines of Scheuner et al. were followed.The pattern of inheritance is the male sex specific ( =13.44). The mean age of onset of diabetes in parents was 58.61 2.94 and in offspring 46.75 2.54. In all 47.22 11.53% families were found in high risk and 31.94 10.77% in the moderate risk category. In female diabetics, the onset was in the age range of 41-60 years.We found a high-risk of diabetes and familial clustering in successive generations of Brahmins with prominent male sex specificity. In females onset of diabetes was coinciding with the period around menopause.

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