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Wilmore, KY, United States

Asbury University, formerly Asbury College, is a Christian liberal arts institution located in Wilmore, Kentucky, United States. Although it is a nondenominational school, the college's foundation stems from a Wesleyan-Holiness tradition. The school offers 50 majors across 17 departments. Primarily a four-year college, Asbury was ranked in the third tier of liberal arts colleges by U.S. News & World Report in 2008. Asbury University's freshman retention rate is above 85 percent. Approximately 34 percent of incoming freshmen are in the top 10 percent of their high school classes, and more than 80 percent of current faculty are full-time.The campus of Asbury Theological Seminary, which became a separate institution in 1940, is located across the street from Asbury University.Asbury University is a member of the Christian College Consortium and the Council for Christian Colleges and Universities.In the fall of 2012, Asbury University had a total enrollment of 1,764: 1,325 traditional undergraduate students, 203 adult degree completion students, and 236 graduate students. Wikipedia.


Stoltzfus K.M.,LCC International University | Cecil D.,Asbury University
Substance Use and Misuse | Year: 2013

This article explores the lived experiences of individuals who have participated in faith-based substance user rehabilitation programs in the Russian Federation. The Russian Federation has high rates of alcohol and opioid dependence and a dearth of professional treatment options. In the post-Soviet period, Evangelical Christian groups have developed substance user rehabilitation programs to attempt to address substance use and its related problems. Data were collected during 2010 via focus group interviews with participants in three Evangelical rehabilitation programs in the Volga region of the Russian Federation. Themes emerging from the qualitative data analysis process were classified into three broad categories: Typical Day, Personal Background/Decision to Enter Rehabilitation, and Helpful Aspects of Rehabilitation Process. © 2013 Informa Healthcare USA, Inc.


Pai V.P.,University of Cincinnati | Pai V.P.,Tufts University | Hernandez L.L.,University of Cincinnati | Hernandez L.L.,University of Wisconsin - Madison | And 2 more authors.
BioMed Research International | Year: 2015

Autocrine-paracrine activity of serotonin (5-hydroxytryptamine, 5-HT) is a crucial homeostatic parameter in mammary gland development during lactation and involution. Published studies suggested that the 5-HTreceptor type was important for mediating several effects of 5-HT in the mammary epithelium. Here, using 5-HTreceptor-null (HT7KO) mice we attempt to understand the role of this receptor in mediating 5-HT actions within the mammary gland. We demonstrate for the first time that HT7KO dams are inefficient at sustaining their pups. Histologically, the HT7KO mammary epithelium shows a significant deviation from the normal secretory epithelium in morphological architecture, reduced secretory vesicles, and numerous multinucleated epithelial cells with atypically displaced nuclei, during lactation. Mammary epithelial cells in HT7KO dams also display an inability to transition from lactation to involution as normally seen by transition from a columnar to a squamous cell configuration, along with alveolar cell apoptosis and cell shedding. Our results show that 5-HTis required for multiple actions of 5-HT in the mammary glands including core functions that contribute to changes in cell shape and cell turnover, as well as specialized secretory functions. Understanding these actions may provide new interventions to improve lactation performance and treat diseases such as mastitis and breast cancer. © 2015 Vaibhav P. Pai et al.


Veliz-Cuba A.,University of Nebraska - Lincoln | Arthur J.,North Carolina State University | Hochstetler L.,Asbury University | Klomps V.,Northwestern College | Korpi E.,University of Wisconsin - River Falls
Bulletin of Mathematical Biology | Year: 2012

For many biological systems that have been modeled using continuous and discrete models, it has been shown that such models have similar dynamical properties. In this paper, we prove that this happens in more general cases. We show that under some conditions there is a bijection between the steady states of continuous and discrete models arising from biological systems. Our results also provide a novel method to analyze certain classes of nonlinear models using discrete mathematics. © 2012 Society for Mathematical Biology.


Anigbogu C.N.,University of Lagos | Anigbogu C.N.,University of Kentucky | Speakman R.O.,University of Kentucky | Silcox D.L.,University of Kentucky | And 11 more authors.
Autonomic Neuroscience: Basic and Clinical | Year: 2012

We recorded arterial pressure (BP) and heart rate (HR) in type-1 diabetic rats vs. controls for > 6. months. Diabetic rats (DIAB) were maintained on insulin from the day glucose >250. mg/dl ("Day 0"). Weight was similar between groups until ~. 3. weeks before Day 0 when the weight in DIAB transiently lagged the controls (CONT); this difference was maintained throughout the study, but both groups otherwise gained weight in parallel. Plasma glucose attained 371 ± 109 (SD) mg/dl by day 1 in DIAB. Mean BP was similar across groups, and declined through the initial 4-6. months in both the CONT (at -0.06 ± 0.04. mm. Hg/day) and in the DIAB (at -0.14 ± 0.21. mm. Hg/day; NS vs. CONT). HR in the CONT (Month 1: 341 ± 13. bpm) exceeded DIAB (325 ± 25. bpm) through ~. 6. months after Day 0, and also decreased progressively over this period in CONT (-0.19 ± 0.14. bpm/day) and DIAB (-0.29 ± 0.23. bpm/day; NS vs. CONT) before leveling. The BP power within 0.35-0.45. Hz changed during the 90. min before vs. after the transition from dark to light, and light to dark; there were no between group differences. The slope of the log-log linear portion of the BP power spectrum between 1.0/h and 1/min was similar across groups, and increased in both from month 1 to month 6. Regulatory mechanisms maintain similar profiles in BP and HR in diabetic vs. control animals through the initial half year of the disease. © 2012 Elsevier B.V.


Brammell B.F.,University of Kentucky | Brammell B.F.,Asbury University | Price D.J.,Lexington Fayette Urban County Government | Elskus A.A.,University of Kentucky | Elskus A.A.,University of Maine, United States
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | Year: 2013

Organisms chronically exposed to organic pollutants such as polychlorinated biphenyls (PCBs) can develop resistance to these chemicals, a condition associated with reduced inducibility of the biomarker enzyme cytochrome P450 1A (CYP1A). This study addresses the CYP1A response of members of the families Ictaluridae and Centrarchidae, two fish families found throughout much of the United States. We measured CYP1A expression, PCB body burdens, and conducted CYP1A challenge experiments in species from these families residing in the Town Branch/Mud River system (Logan County, KY, USA), a stream system historically contaminated with high levels of PCBs. Despite PCB concentrations in muscle tissue typically associated with elevated CYP1A (16.7 to 75.2 μg PCB/g wet edible flesh), resident fish in the contaminated Town Branch/Mud River sites (yellow bullhead [Ameiurus natalis], green sunfish [Lepomis cyanellus], and spotted bass [Micropterus punctulatus]) had hepatic CYP1A activity levels similar to, rather than higher than, those in reference fish, suggesting reduced sensitivity to CYP1A induction. Lack of CYP1A expression following direct contaminant exposure has often been associated with resistance to those contaminants. To determine if CYP1A in resident populations was resistant to induction by PCBs, we exposed resident fish to a single, intraperitoneal injection with a potent CYP1A inducer, 3,4,3′,4′-tetrachlorobiphenyl (PCB 77). PCB 77 treatment significantly induced hepatic CYP1A activity and protein in yellow bullhead from reference, but not contaminated, sites and had no effect on CYP1A in green sunfish from either site. The low CYP1A expression levels in resident fish with elevated PCB body burdens, together with the failure of PCB injection to induce CYP1A in certain populations, indicate an acclimatory CYP1A response in yellow bullheads and likely an inherently resistant CYP1A in green sunfish. This work demonstrates for the first time acclimation of CYP1A to PCBs in a species within the family Ictaluridae and provides further support for our previous work indicating an apparent inherent lack of CYP1A sensitivity to chlorinated inducers in Centrarchids. These traits may explain, at least in part, the common association of these families with degraded habitats and indicate Lepomis members are likely to be excellent candidates for exploring the mechanistic basis of 'inherent' CYP1A resistance. This study also underlines to the need for thorough characterization of the CYP1A responsivity of a population and/or species prior to using CYP1A as a reliable biomonitoring tool. © 2012 Elsevier Inc.

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