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Trademark
Asai Germanium Research Institute Co. | Date: 2015-11-22

Dietary and nutritional supplements.


Trademark
Asai Germanium Research Institute Co. | Date: 2001-04-20

Organic germanium compound. Cosmetics containing organic germanium compound.


Trademark
Asai Germanium Research Institute Co. | Date: 1991-02-19

PHARMACEUTICAL PREPARATIONS CONTAINING ORGANIC GERMANIUM COMPOUND FOR USE AS BIOLOGICAL RESPONSE MODIFIERS, ANTITUMOR AGENTS, INTERFERON INDUCTORS, ANTI-HYPERTENSION AGENTS AND IN THE PREVENTION AND/OR TREATMENT OF COLD SYNDROME IN PNEUMOCONIOSIS, BONE DISEASE, CYTOMEGALOVIRUS AND AIDS.


Yamaguchi H.,Tohoku University | Shimada Y.,Asai Germanium Research Institute Co. | Shimada Y.,Iwate University | Takeda T.,Asai Germanium Research Institute Co. | And 2 more authors.
Analytical Chemistry | Year: 2015

Poly trans-[(2-carboxyethyl)germasesquioxane] (IUPAC name) is the most common water-soluble organic germanium compound. This compound is known as bis(carboxyethyl)germaniumsesquioxide and it is commonly called Ge-132; it is hydrolyzed to 3-(trihydroxygermyl)propanoic acid (THGPA) in water. We have developed a method for the quantification of THGPA in rat plasma, using a novel extraction method based on a reversible chemical conversion. THGPA in plasma is converted to 3-(trichlorogermyl)propanoic acid (TCGPA) under acidic conditions using concentrated hydrochloride, which is followed by extraction with chloroform. TCGPA is then converted back to THGPA through hydrolysis. The extraction recovery of this method is approximately 100%. Moreover, we synthesized deuterated Ge-132, which was used as an internal standard in our experiments. This method covers a linearity range of 0.01-5 μg/mL for concentrations of THGPA in plasma. The intra-day and inter-day precisions of the analysis are about 4.1%, and the accuracy is within ±2.6% at THGPA concentrations of 0.025, 0.25, and 2.5 μg/mL. The total run time is 5 min. Our method was successfully applied to a pharmacokinetic investigation following oral administration of Ge-132. © 2015 American Chemical Society.


Nakamura T.,Asai Germanium Research Institute Co. | Shimada Y.,Asai Germanium Research Institute Co. | Shimada Y.,Iwate University | Takeda T.,Asai Germanium Research Institute Co. | And 3 more authors.
Future Medicinal Chemistry | Year: 2015

In mammals, adrenaline and ATP are life-essential vicinal diol and cis-diol functional groups. Here, we show that interactions between a safe organogermanium compound and these cis-diol compounds have the potential to regulate physiological functions. In addition, we represent a possible new druggable target for controlling the action of cis-diol compounds. Results: We analyzed a single crystal structure of organogermanium 3-(trihydroxygermyl)propanoic acid (THGPA), a hydrolysate of safe Ge-132, in complex with catecholamine (adrenaline and noradrenaline), and evaluated the affinity between several cis-diol compounds and THGPA by NMR. An in vitro study using normal human epidermal keratinocytes was performed to investigate the inhibition of cis-diol compound-stimulated receptors by THGPA. At high concentration, THGPA inhibited the calcium influx caused by adrenaline and ATP. Conclusion: This study demonstrates that THGPA can modify cis-diol-mediated cell-to-cell signaling. © 2015 Future Science Ltd.

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