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Balamurugan K.,Annamalai University | Pabbati A.,Annamalai University | Qayum A.J.A.A.,Annamalai University | Madhana Gopal K.,Arupadaivedu Medical College and Hospital | Meganathan M.,Arupadaivedu Medical College and Hospital
Journal of Chemical and Pharmaceutical Sciences | Year: 2010

The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The methanolic extract of Tribulus terrestris Linn (Zygophyllaceae) fruits was investigated for its hepatoprotective effect on paracetamol (2g/kg/b.wt/p.o) suspended in 1% CMC induced acute liver damage in Wistar albino rats. Hepato protection activity was measured by using biochemical parameters such as serum glutamate oxalate transaminase and serum Glutamate Pyruvate Transaminase (SGOT and SGPT), alkaline phosphatase (ALP), bilirubin, total protein and histopathology was also studied. The methanol extract of Tribulus terrestris (METT) at the dose of (500 mg/kg/p.o) produced significant hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin and proteins. The effects of methanol extract of Tribulus terrestris were comparable to that of standard drug silymarin. These results suggest that methanol extract of Tribulus terrestris have potential therapeutic value in the treatment of some liver disorders.


Balamurugan K.,Annamalai University | Kalaichelvan V.K.,Annamalai University | Savkar T.A.,Annamalai University | Anuradha G.,Annamalai University | And 4 more authors.
Biosciences Biotechnology Research Asia | Year: 2010

The development of new fertility regulating drugs from medicinal plants is an attractive preposition. In the present study an attempt has been made to analyze the possible modulatory influence of methanolic extract of Saccharum officinarum on biochemical constituents (viz. glycogen, sialic acid, cholesterol, acid phosphatase and alkaline phosphatase profile which may play an important role in implantation and foetal development) and histopathology. Administration of methanolic extract of Saccharum officinarum(500mg/kg b.wt/p.o) from day 21st resulted in a statistically significant decline (p<0.01) in the acid phosphatase, alkaline phosphatase activity and glycogen content (p<0.001) when compared with control pregnant rats while the activity of cholesterol is increased as compared to the controls on day21st. Therefore, it can be suggested that the changes in the biochemical constituents of uterus may be responsible, for the anticontraceptive / anti-implantational effect of methanolic extract of Saccharum officinarum in the treated female rats.


Balamurugan K.,Annamalai University | Pabbati A.,Annamalai University | Madhana Gopal K.,Arupadaivedu Medical College and Hospital | Meganathan M.,Arupadaivedu Medical College and Hospital | Manavalan R.,Annamalai University
Journal of Chemical and Pharmaceutical Sciences | Year: 2010

In the present study, antifertility activity, contraceptive activity of methanolic extract of Saccharum officinarum Linn was evaluated. The methanolic extract of Saccharum officinarum showed significant antifertility activity and contraceptive activity. Pretreatment with methanolic extract showed significant inhibition of number of implant site at a dose of 500 mg/kg. There was no change in ovulation, hence the antifertility activity observed in the present study with Saccharum officinarum can be attributed largely to its anti-implantation, blastocidal, antizygotic & abortificant activity.


Meganathan M.,Arupadaivedu Medical College and Hospital | Gopal K.M.,Arupadaivedu Medical College and Hospital | Sasikala P.,Arupadaivedu Medical College and Hospital | Mohan J.,Arupadaivedu Medical College and Hospital | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

In the present studies hepatoprotective activity of omega-3-fatty acids against paracetamol induced hepatic damage in albino rats was observed. Hepatic injury was induced by administering 2g/Kg body wt. p.o. of paracetamol, omega-3-fatty acid at dose levels of 100 mg/Kg/day and 300 mg/Kg/day were administered for albino rats altered and proved to be hepatoprotective and antioxidant action by increasing the levels of Superoxide Dismutase (SOD), Glutathione (GSH), Catalase (CAT). Wet weight of the liver and histopathological studies further confirmed the hepatoprotective and antioxidant activity of omega-3-Fatty acids when compared with paracetamol treated control groups. The result obtained were compared with silymarin (25 mg/Kg body wt. p.o.), the standard drug. In conclusion omega-3-Fatty acids at (300 mg/Kg/day) showed significant p<0.001 hepatoprotective and antioxidant activity similar to that standard drug, silymarin.


Gopal K.M.,Arupadaivedu Medical College and Hospital | Meganathan M.,Arupadaivedu Medical College and Hospital | Mohan J.,Arupadaivedu Medical College and Hospital | Sasikala P.,Arupadaivedu Medical College and Hospital | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

In the present study, the protective effect of fish oil treatment on the fatty acid composition in isoproterenol (IPH)-induced myocardial infarction was studied in male albino Wistar rats. Rats were injected with Isoproterenol, IPH (8.5 mg/Kg, s.c) twice at an interval of 24hrs to induce myocardial infarction. Fish oil was administered orally at 5% v/w for 30 days after which serum and heart tissue were assayed for clinical marker enzymes in the tissue & in determination of biochemical parameters and the remaining tissue was subjected for histopathological studies.Biochemical assessment of myocardial infarction was done by measuring the activities of lipid peroxides(LPO), reduced glutathione (GSH), glutathione peroxidase(GPX), glutathione-S-transferase(GST), superoxide dismutase (SOD), Catalase(CAT), creatine kinase (CK) and serum enzymes which were significantly elevated in the rats administered with IPH. The fish oil treatment for a period of 30 days decreased the levels of cardiac markers (creatinine kinase and biochemical parameters) and reversed the biochemical lesions induced by IPH. Our study suggests that supplement of fish oil protects myocardium against oxidative stress through its antioxidant defence mechanism and anti thrombotic activity and thereby restores the structural and functional integrity of myocardium.


Gowdhaman N.,Arupadaivedu Medical College and Hospital | Adikesavan B.,Government of Puducherry | Madhana Gopal K.,Arupadaivedu Medical College and Hospital | Meganathan M.,Arupadaivedu Medical College and Hospital | And 4 more authors.
World Journal of Medical Sciences | Year: 2011

The current study was focused to find out the relation of pulmonary function (PFT)in female with Rheumatoid arthritis (RA).The study was carried on 100 females with RA in the age group 20-60 years, who fulfill the Revised American Rheumatism Association Criteria (1988). Patients with respiratory illness, smoking habits, treated with methotrexate were excluded from this study. Patients were well examined for height, weight, pulse rate, respiratory rate and blood pressure. These patients were assessed for pulmonary function-Forced vital capacity (FVC) and Maximum Voluntary Ventilation (MVV) in "SPIROLAB II". The results showed that there was negative correlation between duration of disease and the percentage of FVC and MVV. From the study it was concluded that the incidence of pulmonary dysfunction (both obstructive and restrictive pattern) in female patients with RA and it must be pertinent to do Pulmonary Function Test to detect and monitor changes in lung function in subjects with Rheumatoid Arthritis. © IDOSI Publications, 2011.


Sasikala P.,Arupadaivedu Medical College and Hospital | Sulochana S.,Arupadaivedu Medical College and Hospital | Rajan T.,Arupadaivedu Medical College and Hospital | Mohan J.,Arupadaivedu Medical College and Hospital | Melani Rajendran S.,Sri Ramachandra University
World Journal of Medical Sciences | Year: 2013

The variations in origin of renal arteries are very common. The present study was focused to study renal artery and accessory renal artery in correlation with CT Angiography which provides the incidence and characteristics of variations of the renal arteries in cadavers and in patients who underwent angiography for donor nephrectomy. The origin and termination of the renal artery along with incidence, origin, course and termination of accessory renal arteries were studied in detail by dissection and CT angiography. Axial images alone are not sufficient for the evaluation of renal artery because they often have a tortuous and variable course. Additional views provided by CT angiography allow for display of the renal arteries in multiple planes and projections. © IDOSI Publications, 2013.

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