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Reston, VA, United States

Carle A.B.,ARTEL Inc
American Laboratory | Year: 2015

Sorenson Genomics of Salt Lake City focuses on DNA testing, with its expertise in quality, high throughput testing that spans several diverse business units and highly accredited laboratories. The company's Identigene division offers direct-to-consumer paternity and relationship DNA testing, while the Sorenson Forensics division provides DNA-related services to law enforcement for a range of needs. Patient samples for pharmacogenetic and STD testing and tumor biopsies are processed by the company's clinical laboratories. Source

Hentz N.G.,North Carolina State University | Knaide T.R.,ARTEL Inc
Journal of Laboratory Automation | Year: 2014

This study illustrates how optimization of both liquid-handling accuracy and precision is critical to assay performance. The study was designed to examine (1) liquid-handling performance and (2) the effect of liquid-handling variability on two types of in vitro biochemical assays by making small but deliberate changes to assay volume delivery. Specifically, protein binding (streptavidin) and enzyme (α-galactosidase) assays were investigated by determining the effect of assay volume for each assay component. The concomitant effect of the liquid-handling variability was then measured via inhibitor potency and assay performance characteristics such as Z-factor, signal-to-background, and variability. It was found that small changes in assay component volumes were indeed measurable by potency (IC50) but not necessarily by assay variability (Z-factor). In fact, this study demonstrates how a miscalibrated liquid handler can lead to erroneous data. © 2013 Society for Laboratory Automation and Screening. Source

An apparatus used to calibrate microtiter plate readers. The apparatus includes one or more structures having two exterior surfaces wherein one of the exterior surfaces is coated with a coating selected to establish on that surface a reflection loss that mimics reflection loss at an air-liquid interface, and the other of the two exterior surfaces is coated with a coating selected to establish a reflection loss on that surface that mimics the reflection loss at a bottom surface of a microtiter plate. The apparatus may be a single layer, a multi-layered composition or a container. The apparatus is an artifact that may be used to calibrate a plate reader by mimicking a solution-filled microtiter plate. The artifact may be used for a plurality of liquids, including water. The artifact produces reflection losses more closely mirroring reflection losses expected for a liquid-filled microtiter plate well.

The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.


ARTEL Inc | Date: 2016-05-17

Scientific instruments, namely, air dispensing syringes, a sealing gasket, pressure sensors and computer software, sold as a unit, for measuring volumes, not for medical use.

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