Art Photonics GmbH

Berlin, Germany

Art Photonics GmbH

Berlin, Germany
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Bibikova O.,University of Oulu | Bibikova O.,University of Ulm | Bibikova O.,Art Photonics GmbH | Bibikova O.,Chernyshevsky Saratov State University | And 8 more authors.
Analyst | Year: 2017

We report the preparation and characterization of plasmonic chip-based systems comprising self-assembled gold nanostars at silicon substrates that enable concomitantly enhanced Raman (surface enhanced Raman spectroscopy; SERS) and mid-infrared (surface enhanced infrared reflection or absorption spectroscopy; SEIRA) spectral signatures. The high-aspect-ratio structure of gold nanostars provides an increased number of hot spots at their surface, which results in an electric field enhancement around the nanomaterial. Gold nanostars were immobilized at a silicon substrate via a thin gold layer, and α-ω-dimercapto polyethylene glycol (SH-PEG-SH) linkers. The Raman and IR spectra of crystal violet (CV) revealed a noticeable enhancement of the analyte vibrational signal intensity in SERS and SEIRA studies resulting from the presence of the nanostars. Enhancement factors of 2.5 × 103 and 2.3 × 103 were calculated in SERS considering the CV bands at 1374.9 cm-1 and 1181 cm-1, respectively; for SEIRA, an enhancement factor of 5.36 was achieved considering the CV band at 1585 cm-1. This journal is © The Royal Society of Chemistry.

Eccleston R.,Cologne University of Applied Sciences | Wolf C.,Cologne University of Applied Sciences | Balsam M.,Cologne University of Applied Sciences | Schulte F.,art photonics GmbH | And 2 more authors.
Chemical Engineering and Technology | Year: 2016

To develop an online probe that is not only sufficiently robust, but also able to measure crucial process variables in biogas plants is a tough challenge. Therefore, a mid-infrared (MIR) spectroscopic attenuated total reflection (ATR) probe and robust probe fitting were established. A fully automated probe control, calibration after probe cleaning, and analysis of the absorption spectra using machine learning were implemented in order to reduce maintenance of the probe to a minimum. The relevant wavelengths in the MIR spectrum for organic acids, total alkalinity, and ammonium nitrogen concentration were identified. Finally, intensive lab testing was carried out, followed by operation of the complete online measurement system at an industrial biogas plant. In order to improve signal strength and sensitivity, microelectronic mechanical system (MEMS)-based Fabry-Pérot interferometers were also investigated. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Artyushenko V.,Art Photonics GmbH | Schulte F.,Art Photonics GmbH | Zabarylo U.,Art Photonics GmbH | Berlien H.-P.,Lasermedizin Evangelische Elisabeth Klinik | And 9 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2015

Cancer is one of the leading causes for morbidity and mortality worldwide. Therefore, efforts are concentrated on cancer detection in an early stage to enhance survival rates for cancer patients. A certain intraoperative navigation in the tumor border zone is also an essential task to lower the mortality rate after surgical treatment. Molecular spectroscopy methods proved to be powerful tools to differentiate cancerous and healthy tissue. Within our project comparison of different vibration spectroscopy methods were tested to select the better one or to reach synergy from their combination. One key aspect was in special fiber probe development for each technique. Using fiber optic probes in Raman, MIR and NIR spectroscopy is a very powerful method for non-invasive in vivo applications. Miniaturization of Raman probes was achieved by deposition of dielectric filters directly onto the silica fiber end surfaces. Raman, NIR and MIR spectroscopy were used to analyze samples from kidney tumors. The differentiation between cancer and healthy samples was successfully obtained by multivariate data analysis. © 2015 SPIE.

Bogomolov A.,Art Photonics GmbH | Bogomolov A.,Samara State Technical University | Ageev V.,Art Photonics GmbH | Zabarylo U.,Art Photonics GmbH | And 10 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2016

Optical spectroscopic technologies are increasingly used for cancer diagnostics. Feasibility of differentiation between malignant and healthy samples of human kidney using Fluorescence, Raman, MIR and NIR spectroscopy has been recently reported. In the present work, a simplification of NIR spectroscopy method has been studied. Traditional high-resolution NIR spectrometry was replaced by an optical sensor based on a set of light-emitting diodes at selected wavelengths as light sources and a photodiode. Two prototypes of the sensor have been developed and tested using 14 in-vitro samples of seven kidney tumor patients. Statistical evaluation of results using principal component analysis and partial least-squares discriminant analysis has been performed. Despite only partial discrimination between tumor and healthy tissue achieved by the presented new technique, the results evidence benefits of LED-based near-infrared sensing used for oncological diagnostics. Publisher's Note: This paper, originally published on 4 March, 2016, was replaced with a corrected/revised version on 7 April, 2016. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Library Customer Service for assistance. © 2016 SPIE.

Bogomolov A.,J and M Analytik AG | Bogomolov A.,Samara State Technical University | Hessling M.,Ulm University of Applied Sciences | Wenzel U.,Ulm University of Applied Sciences | And 7 more authors.
Sensors and Actuators, B: Chemical | Year: 2015

Three prototypes of mid-infrared (MIR) spectrometric sensor systems for simultaneous monitoring of ethanol and carbohydrates (in the present case glucose and fructose) in the course of biotechnological processes have been constructed based on recent developments in pyroelectric detection and fiber photonics. The sensors utilized were a grating spectrometer or a Fabry-Pérot interferometer adjusted for the detection of analytes' characteristic absorbance bands in the spectral region of "fingerprints" between 1050 and 950cm-1. The measurements were performed with an attenuated total reflection (ATR) probe connected to the spectrometer by a polycrystalline infrared fiber (PIR). Two probes with different ATR elements were tested: with a diamond crystal (for both spectrometers) and with a detachable PIR loop head (for grating spectrometer). The sensor performances were assessed and compared using partial least-squares (PLS) regression modeling and prediction statistics for two designed sample sets of binary ethanol-glucose and glucose-fructose aqueous solutions. The models based on the FT-IR spectroscopic analysis of the same designed samples using a diamond ATR probe (a "gold standard" method) were used as a benchmark. The system based on a grating spectrometer connected to an ATR probe with a PIR loop head was additionally tested under the process conditions of Saccharomyces cerevisiae fermentation. The resulting root mean-square errors of prediction were 4.74 and 13.33g/L, for ethanol and glucose models, respectively. Simultaneously, NIR spectroscopy in the range 1100-2100nm was used both for the analysis of designed samples and for the fermentation process monitoring. In the latter case a biomass content prediction model has been built along with those for ethanol and glucose. All tested full-spectroscopic and sensor-based methods of analysis have been compared and their practical applications discussed. © 2015 Elsevier B.V.

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