Joinville-le-Pont, France
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Blat S.,French National Institute for Agricultural Research | Vincent S.,UEB ENS Rennes M2S | Lefeuvre L.,UEB ENS Rennes M2S | Lemoine-Morel S.,UEB ENS Rennes M2S | And 4 more authors.
Obesity | Year: 2015

Objective The pandemic of obesity in Western countries is mainly due to the high-fat, high-energy diet prevailing there. Obesity-associated metabolic disorders are the consequence of fat mass increase leading to altered adipokine secretion, hyperlipemia, oxidant stress, low-grade inflammation, and eventually glucose intolerance. Yet not all people consuming a Western diet become obese, and the question is raised whether these people are also at risk of developing metabolic disorders. Methods Glucose tolerance, lipid profile, and oxidant and inflammation status were investigated longitudinally in lean Göttingen minipigs receiving for 16 weeks either a normal diet (ND), a Western diet (WD), or a Western diet supplemented with a whey protein isolate (WPI) rich in α-lactalbumin known to improve glucose tolerance. ND and WD were supplied isoenergetically. Results Lean minipigs fed WD displayed glucose intolerance and altered lipid profile after 6 weeks of diet but no inflammation or oxidative stress. Supplementation with WPI alleviated glucose intolerance by improving insulin secretion, but not lipid profile. Conclusions Western diet consumption is deleterious for glucose tolerance even in the absence of fat mass accretion, and dyslipemia is a major determinant for this metabolic dysfunction. Stimulating insulin secretion with a WPI is an effective strategy to improve glucose tolerance. © 2014 The Obesity Society.


Protein Hydrolysate Ingredients Market Will Increase at a CAGR of 6.2% During 2016-2024 Future Market Insights has announced the addition of the "Protein Hydrolysate Ingredients Market: Global Industry Analysis and Opportunity Assessment 2016-2024" report to their offering. Valley Cottage, NY, February 24, 2017 --( With respect to their forecast report, Future Market Insights predicts that the global market for protein hydrolysate ingredients, which is presently valued at an estimated US$ 3.1 billion, will expand at a robust CAGR of 6.2% to reach US$ 5.1 billion revenues by 2024-end. Outright Preference to Milk Protein Hydrolysates In 2016, nearly 85% of the global protein hydrolysate ingredients revenues were accounted by milk ingredients, attesting the fact that more consumers in the world prefer consuming protein hydrolysates in the form of casein, whey or other milk ingredients. The demand for meat-based protein hydrolysate ingredients will remain lower owing to a comparatively sluggish assimilation of proteins after consuming products derived from such ingredients. Meanwhile, global revenues raked in from sales of whey protein hydrolysate ingredients will be expanding at the highest CAGR of 6.7%, reaching nearly US$ 3 billion market value by the end of 2024. Over the forecast period, approximately 36,000 MT of casein protein hydrolysate ingredients will be consumed globally. Request For Sample@ http://www.futuremarketinsights.com/reports/sample/rep-gb-1062 Higher Demand for Powdered Protein Hydrolysates Over two-third of the global protein hydrolysate ingredients market value, estimated in 2016, was accounted by sales of powder products. The demand for powder products will remain high throughout the forecast period on the grounds of soaring consumption of nutrient powders, powdered baby food products and powdered fitness supplement products across the globe. However, liquid products containing protein hydrolysate ingredients will witness an impressive growth in revenues, registering a 6.3% CAGR by 2024. And, global consumption of protein hydrolysate ingredients in the form of nutrient bars will account for sales of nearly 17,000 MT during the projected period. Infant Formula – Lucrative Application for Protein Hydrolysate Ingredients Over the next decade, the application of protein hydrolysates is likely to foray into the intricate biotechnology industry as several studies of hydrolysates are rendering them as a supplement for cell culture and tissue cultivation. But, production of infant formulas will remain the key application of protein hydrolysate ingredients through 2024. Reaching an estimated US$ 3.5 billion market value by 2024-end, infant formulas will outpace the sports & slimming food segment at a substantial rate. In fact, the use of protein hydrolysate ingredients in production of clinical nutrition products will amass revenues that will be much higher than those harvested through sports and slimming food applications, during the forecast period. Send An Enquiry@ http://www.futuremarketinsights.com/askus/rep-gb-1062 According to the report, titled “Protein Hydrolysate Ingredients Market: Global Industry Analysis & Opportunity Assessment, 2016-2024,” Future Market Insights estimates that North America and Europe will collectively dominate the global protein hydrolysate ingredients market by procuring more than 60% revenue share by 2024. Leading European dairy product manufacturers such as Armor Proteines (France), Glanbia Ingredients (Ireland), Carbery Group Limited (Ireland), and Arla Foods Ingredients Group (Denmark) are observed as some of the key players in the global protein hydrolysate ingredients market. North America’s protein hydrolysate ingredients market is expected to attain robust growth on the account of presence of prominent protein hydrolysate manufacturers such as Abbot Laboratories, PGP International, Groupe Danone, Davisco Foods International, Inc., Kerry Group, and the Hilmar Cheese Company. The protein hydrolysate ingredients market in Asia-Pacific (APAC) region, on the other hand, will incur fastest growth in terms of revenues and exhibit expansion at 7.7% CAGR over the forecast period. Browse Full Report@ http://www.futuremarketinsights.com/reports/protein-hydrolysate-ingredient-market Valley Cottage, NY, February 24, 2017 --( PR.com )-- On the account of rising occurrences of sports-related physical injuries in the world, the need for rapid recovery will continue to be prioritised in the years to come. Presence of protein hydrolysate ingredients in sports medicine, nutritional supplements as well as baby food products will continue to gain traction in order to avert health risks caused to children and adults due to muscle strain-related injuries. A recent study developed by Future Market Insights has estimated that in 2016, over 100,000 MT of protein hydrolysate ingredients were sold through sales of such products. By the end of 2024, the global protein hydrolysate ingredients consumption is projected to reach 135,609 MT in volumes.With respect to their forecast report, Future Market Insights predicts that the global market for protein hydrolysate ingredients, which is presently valued at an estimated US$ 3.1 billion, will expand at a robust CAGR of 6.2% to reach US$ 5.1 billion revenues by 2024-end.Outright Preference to Milk Protein HydrolysatesIn 2016, nearly 85% of the global protein hydrolysate ingredients revenues were accounted by milk ingredients, attesting the fact that more consumers in the world prefer consuming protein hydrolysates in the form of casein, whey or other milk ingredients. The demand for meat-based protein hydrolysate ingredients will remain lower owing to a comparatively sluggish assimilation of proteins after consuming products derived from such ingredients. Meanwhile, global revenues raked in from sales of whey protein hydrolysate ingredients will be expanding at the highest CAGR of 6.7%, reaching nearly US$ 3 billion market value by the end of 2024. Over the forecast period, approximately 36,000 MT of casein protein hydrolysate ingredients will be consumed globally.Request For Sample@ http://www.futuremarketinsights.com/reports/sample/rep-gb-1062Higher Demand for Powdered Protein HydrolysatesOver two-third of the global protein hydrolysate ingredients market value, estimated in 2016, was accounted by sales of powder products. The demand for powder products will remain high throughout the forecast period on the grounds of soaring consumption of nutrient powders, powdered baby food products and powdered fitness supplement products across the globe. However, liquid products containing protein hydrolysate ingredients will witness an impressive growth in revenues, registering a 6.3% CAGR by 2024. And, global consumption of protein hydrolysate ingredients in the form of nutrient bars will account for sales of nearly 17,000 MT during the projected period.Infant Formula – Lucrative Application for Protein Hydrolysate IngredientsOver the next decade, the application of protein hydrolysates is likely to foray into the intricate biotechnology industry as several studies of hydrolysates are rendering them as a supplement for cell culture and tissue cultivation. But, production of infant formulas will remain the key application of protein hydrolysate ingredients through 2024. Reaching an estimated US$ 3.5 billion market value by 2024-end, infant formulas will outpace the sports & slimming food segment at a substantial rate. In fact, the use of protein hydrolysate ingredients in production of clinical nutrition products will amass revenues that will be much higher than those harvested through sports and slimming food applications, during the forecast period.Send An Enquiry@ http://www.futuremarketinsights.com/askus/rep-gb-1062According to the report, titled “Protein Hydrolysate Ingredients Market: Global Industry Analysis & Opportunity Assessment, 2016-2024,” Future Market Insights estimates that North America and Europe will collectively dominate the global protein hydrolysate ingredients market by procuring more than 60% revenue share by 2024. Leading European dairy product manufacturers such as Armor Proteines (France), Glanbia Ingredients (Ireland), Carbery Group Limited (Ireland), and Arla Foods Ingredients Group (Denmark) are observed as some of the key players in the global protein hydrolysate ingredients market.North America’s protein hydrolysate ingredients market is expected to attain robust growth on the account of presence of prominent protein hydrolysate manufacturers such as Abbot Laboratories, PGP International, Groupe Danone, Davisco Foods International, Inc., Kerry Group, and the Hilmar Cheese Company. The protein hydrolysate ingredients market in Asia-Pacific (APAC) region, on the other hand, will incur fastest growth in terms of revenues and exhibit expansion at 7.7% CAGR over the forecast period.Browse Full Report@ http://www.futuremarketinsights.com/reports/protein-hydrolysate-ingredient-market Click here to view the list of recent Press Releases from Future Market Insights


Protein Hydrolysate Ingredients Market Expected to Grow at a CAGR of 6.2% During 2016-2024 Future Market Insights has announced the addition of the “Protein Hydrolysate Ingredients Market: Global Industry Analysis and Opportunity Assessment 2016-2024" report to their offering. Valley Cottage, NY, February 26, 2017 --( With respect to their forecast report, Future Market Insights predicts that the global market for protein hydrolysate ingredients, which is presently valued at an estimated US$ 3.1 billion, will expand at a robust CAGR of 6.2% to reach US$ 5.1 billion revenues by 2024-end. Outright Preference to Milk Protein Hydrolysates In 2016, nearly 85% of the global protein hydrolysate ingredients revenues were accounted by milk ingredients, attesting the fact that more consumers in the world prefer consuming protein hydrolysates in the form of casein, whey or other milk ingredients. The demand for meat-based protein hydrolysate ingredients will remain lower owing to a comparatively sluggish assimilation of proteins after consuming products derived from such ingredients. Meanwhile, global revenues raked in from sales of whey protein hydrolysate ingredients will be expanding at the highest CAGR of 6.7%, reaching nearly US$ 3 billion market value by the end of 2024. Over the forecast period, approximately 36,000 MT of casein protein hydrolysate ingredients will be consumed globally. Request For Sample@ http://www.futuremarketinsights.com/reports/sample/rep-gb-1062 Higher Demand for Powdered Protein Hydrolysates Over two-third of the global protein hydrolysate ingredients market value, estimated in 2016, was accounted by sales of powder products. The demand for powder products will remain high throughout the forecast period on the grounds of soaring consumption of nutrient powders, powdered baby food products and powdered fitness supplement products across the globe. However, liquid products containing protein hydrolysate ingredients will witness an impressive growth in revenues, registering a 6.3% CAGR by 2024. And, global consumption of protein hydrolysate ingredients in the form of nutrient bars will account for sales of nearly 17,000 MT during the projected period. Infant Formula – Lucrative Application for Protein Hydrolysate Ingredients Over the next decade, the application of protein hydrolysates is likely to foray into the intricate biotechnology industry as several studies of hydrolysates are rendering them as a supplement for cell culture and tissue cultivation. But, production of infant formulas will remain the key application of protein hydrolysate ingredients through 2024. Reaching an estimated US$ 3.5 billion market value by 2024-end, infant formulas will outpace the sports & slimming food segment at a substantial rate. In fact, the use of protein hydrolysate ingredients in production of clinical nutrition products will amass revenues that will be much higher than those harvested through sports and slimming food applications, during the forecast period. Send An Enquiry@ http://www.futuremarketinsights.com/askus/rep-gb-1062 According to the report, titled “Protein Hydrolysate Ingredients Market: Global Industry Analysis & Opportunity Assessment, 2016-2024,” Future Market Insights estimates that North America and Europe will collectively dominate the global protein hydrolysate ingredients market by procuring more than 60% revenue share by 2024. Leading European dairy product manufacturers such as Armor Proteines (France), Glanbia Ingredients (Ireland), Carbery Group Limited (Ireland), and Arla Foods Ingredients Group (Denmark) are observed as some of the key players in the global protein hydrolysate ingredients market. North America’s protein hydrolysate ingredients market is expected to attain robust growth on the account of presence of prominent protein hydrolysate manufacturers such as Abbot Laboratories, PGP International, Groupe Danone, Davisco Foods International, Inc., Kerry Group, and the Hilmar Cheese Company. The protein hydrolysate ingredients market in Asia-Pacific (APAC) region, on the other hand, will incur fastest growth in terms of revenues and exhibit expansion at 7.7% CAGR over the forecast period. Browse Full Report@ http://www.futuremarketinsights.com/reports/protein-hydrolysate-ingredient-market Valley Cottage, NY, February 26, 2017 --( PR.com )-- On the account of rising occurrences of sports-related physical injuries in the world, the need for rapid recovery will continue to be prioritised in the years to come. Presence of protein hydrolysate ingredients in sports medicine, nutritional supplements as well as baby food products will continue to gain traction in order to avert health risks caused to children and adults due to muscle strain-related injuries. A recent study developed by Future Market Insights has estimated that in 2016, over 100,000 MT of protein hydrolysate ingredients were sold through sales of such products. By the end of 2024, the global protein hydrolysate ingredients consumption is projected to reach 135,609 MT in volumes.With respect to their forecast report, Future Market Insights predicts that the global market for protein hydrolysate ingredients, which is presently valued at an estimated US$ 3.1 billion, will expand at a robust CAGR of 6.2% to reach US$ 5.1 billion revenues by 2024-end.Outright Preference to Milk Protein HydrolysatesIn 2016, nearly 85% of the global protein hydrolysate ingredients revenues were accounted by milk ingredients, attesting the fact that more consumers in the world prefer consuming protein hydrolysates in the form of casein, whey or other milk ingredients. The demand for meat-based protein hydrolysate ingredients will remain lower owing to a comparatively sluggish assimilation of proteins after consuming products derived from such ingredients. Meanwhile, global revenues raked in from sales of whey protein hydrolysate ingredients will be expanding at the highest CAGR of 6.7%, reaching nearly US$ 3 billion market value by the end of 2024. Over the forecast period, approximately 36,000 MT of casein protein hydrolysate ingredients will be consumed globally.Request For Sample@ http://www.futuremarketinsights.com/reports/sample/rep-gb-1062Higher Demand for Powdered Protein HydrolysatesOver two-third of the global protein hydrolysate ingredients market value, estimated in 2016, was accounted by sales of powder products. The demand for powder products will remain high throughout the forecast period on the grounds of soaring consumption of nutrient powders, powdered baby food products and powdered fitness supplement products across the globe. However, liquid products containing protein hydrolysate ingredients will witness an impressive growth in revenues, registering a 6.3% CAGR by 2024. And, global consumption of protein hydrolysate ingredients in the form of nutrient bars will account for sales of nearly 17,000 MT during the projected period.Infant Formula – Lucrative Application for Protein Hydrolysate IngredientsOver the next decade, the application of protein hydrolysates is likely to foray into the intricate biotechnology industry as several studies of hydrolysates are rendering them as a supplement for cell culture and tissue cultivation. But, production of infant formulas will remain the key application of protein hydrolysate ingredients through 2024. Reaching an estimated US$ 3.5 billion market value by 2024-end, infant formulas will outpace the sports & slimming food segment at a substantial rate. In fact, the use of protein hydrolysate ingredients in production of clinical nutrition products will amass revenues that will be much higher than those harvested through sports and slimming food applications, during the forecast period.Send An Enquiry@ http://www.futuremarketinsights.com/askus/rep-gb-1062According to the report, titled “Protein Hydrolysate Ingredients Market: Global Industry Analysis & Opportunity Assessment, 2016-2024,” Future Market Insights estimates that North America and Europe will collectively dominate the global protein hydrolysate ingredients market by procuring more than 60% revenue share by 2024. Leading European dairy product manufacturers such as Armor Proteines (France), Glanbia Ingredients (Ireland), Carbery Group Limited (Ireland), and Arla Foods Ingredients Group (Denmark) are observed as some of the key players in the global protein hydrolysate ingredients market.North America’s protein hydrolysate ingredients market is expected to attain robust growth on the account of presence of prominent protein hydrolysate manufacturers such as Abbot Laboratories, PGP International, Groupe Danone, Davisco Foods International, Inc., Kerry Group, and the Hilmar Cheese Company. The protein hydrolysate ingredients market in Asia-Pacific (APAC) region, on the other hand, will incur fastest growth in terms of revenues and exhibit expansion at 7.7% CAGR over the forecast period.Browse Full Report@ http://www.futuremarketinsights.com/reports/protein-hydrolysate-ingredient-market Click here to view the list of recent Press Releases from Future Market Insights


Forster R.,CiToxLAB France | Bourtourault M.,Armor Proteines | Chung Y.J.,Nestlé | Silvano J.,CiToxLAB France | And 5 more authors.
Regulatory Toxicology and Pharmacology | Year: 2014

TM0601p is a whey protein isolate derived from cow milk, containing a concentrated amount of transforming growth factor β2 (TGF-β2), and is intended for nutritional use in infants and adults. In vivo and in vitro studies have been performed to evaluate the safety of this product. In a 13-week toxicity study, treatment of adult Sprague-Dawley rats by gavage at up to 2000. mg/kg/day did not result in any significant findings other than minor non-adverse changes in urinary parameters in females. The no-observed-adverse-effect level (NOAEL) was established as 2000. mg/kg/day. In a juvenile toxicity study, rat pups received 600. mg/kg/day by gavage from postnatal day (PND) 7 to PND 49. Transient lower bodyweight gain in the pre-weaning period was attributed to gastrointestinal effects of the viscous test material; following weaning, bodyweight gain was comparable to the vehicle controls. Reduced eosinophil counts and changes in urinary parameters (females) were recorded in treated pups at PND 49, and higher thymus weights were recorded in males only at the end of the recovery period (Day 77). None of the findings were considered adverse. There were no other significant findings and the NOAEL was established as 600. mg/kg/day. No evidence of genotoxicity was seen in the bacterial reverse mutation test or the in vitro micronucleus test. Overall the results obtained present a reassuring safety profile for TM0601p. © 2014 Elsevier Inc.


Malet A.,Agro ParisTech | Bournaud E.,Agro ParisTech | Lan A.,Agro ParisTech | Mikogami T.,Armor Proteines | And 2 more authors.
Bone | Year: 2011

We have previously shown that bovine lactoferrin (bLF) supplementation can have a beneficial effect on postmenopausal bone loss by modulating bone formation and resorption. A direct effect of bLF on bone metabolism is support by its presence in mice blood. Moreover we know that LF plays a key role in innate immunity and recent studies have shown its ability to modulate adaptive immunity. In particular bLF ingestion prevents recruitment and activation of immune cells at inflammatory sites. We propose that LF through its ability to modulate maturation and differentiation of leucocytes can participate to abolish the deregulation induced by estrogen deficiency on T cells. This study evaluated the effects of bovine lactoferrin on immune function in ovariectomized mice. We investigated whether bLF ingestion could prevent bone loss via modulation of immune function. Three-month-old female C3H mice were either ovariectomized or sham-operated and fed for 1, 2 or 4. months with a control diet (AIN-93M) or the same diet including 10. g bLF/kg diet. Bone mineral density was determined using a Lunar Piximus densitometer. The immune parameters were assessed by flow cytometry. In addition, Real-Time PCR was performed to quantify TNFα expression and plasma cytokines were measured at 4. months with Luminex. Ovariectomy induced significant changes on bone parameters and increased recruitment of macrophages, dendritic cells, and B and T cells associated with T lymphocyte activation in bone marrow. Compared to the control diet, ingestion of bLF-enriched diet for 2. months prevented T cell activation and restored dendritic and B cell populations in the bone micro-environment in ovariectomized mice. Furthermore, TNFα expression in bone was decreased by bLF supplementation after 2 and 4. months. Similarly, a decreased plasma level of TNFα was observed concomitantly to an increase of IL-10 level. In conclusion, these experiments suggest that bLF can mediate the prevention of lymphocyte activation and cytokine release in the bone micro-environment. Dietary bLF supplementation could have a beneficial effect on postmenopausal bone loss by modulating immune function. © 2011 Elsevier Inc.

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