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Patent
ARMO BioSciences | Date: 2017-08-30

Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.


Oft M.,ARMO BioSciences
Blood | Year: 2013

In this issue of Blood, Neven et al report that a third of the patients with interleukin-10 receptor (IL-10R) deficiency develop B-cell lymphomas in the first decade of their life. The lymphomas uniformly contained amplifications of c-rel, activation of inflammatory nuclear factor kB (NF-kB) target genes, and a defective intratumoral CD81 T-cell tumor immunosurveillance. © 2013 by The American Society of Hematology.


Patent
ARMO BioSciences | Date: 2016-05-26

Methods of modulating immune responses in subjects having oncology- and immune-related diseases, disorders and conditions by the administration of an IL-10 agent, including pegylated IL-10.


Patent
ARMO BioSciences | Date: 2015-01-09

Methods for determining dosing parameters associated with subcutaneous administration of IL-10 useful for the treatment and/or prevention of a cholesterol-related disease, disorder or condition, and pharmaceutical compositions associated therewith, are provided herein. Certain embodiments are directed to means for establishing a therapeutic range of an IL-10 agent in a subject. In some embodiments, particular parameters (e.g., hematological parameters) are monitored to provide an indication of the upper limit of the therapeutic range such that any untoward adverse effects are avoided.


Patent
ARMO BioSciences | Date: 2014-09-16

The present invention relates to the use of a peptide, or derivative thereof of general formula X_(1)X_(2)X_(3)-Thr-X_(4)-Lys-X_(5)-Arg-X_(6 )for promoting accelerated wound healing with reduced scarring. X_(1 )is Ala or Gly; X_(2 )is Tyr or Phe; X_(3), X_(4 )and X_(5 )are independently selected from the group comprising Met, Ile, Leu and Val; and X_(6 )is selected from the group comprising Asp, Gln and Glu.


Patent
ARMO BioSciences | Date: 2014-04-15

Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.


Patent
ARMO BioSciences | Date: 2014-08-26

Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided, More particularly, the present disclosure relates to optimized dosing parameters to achieve and maintain efficacy in the treatment and/or prevention of metabolic diseases, disorders and conditions in a subject, while minimizing the adverse effects associated therewith. Particular embodiments are directed to the treatment and/or prevention of abnormally high levels of cholesterol and/or manifestation(s) of hypercholesterolemia in as subject.


Patent
ARMO BioSciences | Date: 2014-11-07

Methods of treating subjects having diseases, disorders, or conditions, including cancer and immune- and inflammatory-related disorders, via the administration of IL-10 in combination with one or more additional agents, and methods and models associated therewith, are provided.


Patent
ARMO BioSciences | Date: 2014-04-23

Interleukin-10 muteins and other interleukin-10-related molecules are described, as well as methods of identifying interleukin-10 muteins and other interleukin-10-related molecules. Also described herein are modifications of the foregoing, which modifications may enhance a property (e.g., half-life) of the muteins or other molecules compared to human interleukin-10. Particular interleukin-10 muteins and related molecules have comparable immunogenicity to human interleukin-10 and/or bioactivity at least comparable to human interleukin-10. Pharmaceutical compositions and methods of use are also described herein.


Patent
ARMO BioSciences | Date: 2014-06-13

The present invention relates to methods and other technologies that may be used to determine whether compositions (e.g., pharmaceutical compositions) comprising interleukin-10 molecules (e.g., pegylated interleukin-10) meet particular product-related specifications prior to being administered to a subject for the treatment and/or prevention of the diseases, disorders and conditions, and/or the symptoms thereof, described herein.

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