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Yerevan, Armenia

The National Academy of science of the Republic of Armenia is the primary body that conducts research and coordinates activities in the fields of science and social science in Armenia. Wikipedia.

Mayilyan K.R.,Armenian National Academy of Sciences
Protein and Cell | Year: 2012

The complement system is a key component of innate immunity. More than 45 genes encoding the proteins of complement components or their isotypes and subunits, receptors, and regulators have been discovered. These genes are distributed throughout different chromosomes, with 19 genes comprising three significant complement gene clusters in the human genome. Genetic deficiency of any early component of the classical pathway (C1q, C1r/s, C2, C4, and C3) is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response. Deficiencies of mannan-binding lectin (MBL) and the early components of the alternative (factor D, properdin) and terminal pathways (from C3 onward components: C5, C6, C7, C8, C9) increase susceptibility to infections and their recurrence. While the association of MBL deficiency with a number of autoimmune and infectious disorders has been well established, the effects of the deficiency of other lectin pathway components (ficolins, MASPs) have been less extensively investigated due to our incomplete knowledge of the genetic background of such deficiencies and the functional activity of those components. For complement regulators and receptors, the consequences of their genetic deficiency vary depending on their specific involvement in the regulatory or signalling steps within the complement cascade and beyond. This article reviews current knowledge and concepts about the genetic load of complement component deficiencies and their association with diseases. An integrative presentation of genetic data with the latest updates provides a background to further investigations of the disease association investigations of the complement system from the perspective of systems biology and systems genetics. © 2012 Higher Education Press and Springer-Verlag Berlin Heidelberg. Source

Kurtikyan T.S.,Armenian National Academy of Sciences | Ford P.C.,University of California at Santa Barbara
Chemical Communications | Year: 2010

The oxy-globin models Fe(Por)(NH3)(O2), prepared by sequential reactions of O2 (18O2) and NH 3 with thin porous layers of FeII(Por), react with NO (15NO) at 80-100 K to form only the low-spin nitrato complexes Fe(Por)(NH3)(η1-ONO2), thus implying that peroxynitrite intermediates, if formed, must undergo very facile isomerization to the nitrato analog. © 2010 The Royal Society of Chemistry. Source

Fleck M.,University of Vienna | Petrosyan A.M.,Armenian National Academy of Sciences
Journal of Crystal Growth | Year: 2010

In the crystallographic literature, there is an ever-increasing number of publications on crystals that are referred to as 'new non-linear optical materials', many of them reporting salts of amino acids. However, the term NLO material is used improperly in most cases. In fact, the establishment of any crystal species as such a material requires several experimental and computational procedures, which are seldom satisfied when characterizing a supposedly new species. Here, some frequent hazards and problems are addressed and observations of papers reporting amino acid compounds as supposedly new NLO materials are made. © 2010 Elsevier B.V. All rights reserved. Source

Gasparyan V.K.,Armenian National Academy of Sciences
Colloids and Surfaces B: Biointerfaces | Year: 2010

Immunoagglutination properties of silver nanoparticles sensitized with antibodies to human IgG for determination of IgG were studied. Effects of various pH on sensitization and consequent immunoagglutination process were investigated. It was shown that the best results were obtained when sensitization and immunoagglutination were conducted at isoelectric point of IgG molecule. It was demonstrated that immunoassay with colloidal silver nanoparticles provides the detection of antigen in wide range of concentrations. © 2010 Elsevier B.V. Source

Ishkhanyan A.M.,Armenian National Academy of Sciences
EPL | Year: 2015

We present the exact solution of the stationary Schrödinger equation for the potential V0/√x. Each of the two fundamental solutions that compose the general solution of the problem is given by a combination with non-constant coefficients of two confluent hypergeometric functions of a shifted argument. Alternatively, the solution is written through the first derivative of a tri-confluent Heun function. Apart from the quasi-polynomial solutions provided by the energy specification En = E1 n-2/3, we discuss the bound-state wave functions vanishing both at infinity and in the origin. The exact spectrum equation involves two Hermite functions of non-integer order which are not polynomials. An accurate approximation for the spectrum providing a relative error less than 10-3 is En = E1 (n-1/2π)-2/3. Each of the wave functions of bound states in general involves a combination with non-constant coefficients of two confluent hypergeometric and two non-integer order Hermite functions of a scaled and shifted coordinate. © EPLA, 2015. Source

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