Armed Police Medical College

Tianjin, China

Armed Police Medical College

Tianjin, China

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Zhou W.,Armed Police Medical College | Chen L.,Armed Police Medical College | Zhang M.,Armed Police Medical College
Chinese Journal of Rehabilitation Medicine | Year: 2011

Objective: To establish a rat treadmill exercises model and to investigate the activity changes of total antioxidant capacity (T-AOC), catalase (CAT) and hydroxyl free radical (OH-) in rat brain after treadmill exercises training of different intensity. Method: Eighty male SD rats were randomly divided into four groups: normal control group, aerobic exercises group (incremental load exercise), anaerobic exercises group (high-speed intermittent training) and alterntive-training group aerobic and anaerobic alternative training. The activity of T-AOC, CAT and the inhibition ability of OH - were measured after every training period. Result: The inhibition ability of OH ' of rat brain in aerobic exercise group was lower than that in the other groups (P<0.05). However, after six-week training, there was no significant difference between four groups. Activity of CAT rat brain in alternative-training group was higher than that in the other three groups (P<0.05), and it was low in anaerobic group (P<0.01). The T-AOC of rat brain in aerobic exercise group was higher compared with normal control group (P<0.01). Conclusion: Oxidative damages of aerobic exercise were heavier than the other groups. But with the extension of training period, the antioxidant capacity increased. It suggested that after moderate aerobic exercises for a long term organism's antioxidant activity would be enhanced.


Yu L.,Armed Police Medical College | Zhou W.,Armed Police Medical College | Chen L.,Armed Police Medical College
Chinese Journal of Rehabilitation Medicine | Year: 2011

Objective: To observe the changes of activities of total-superoxide dismutase (T-SOD), manganese-superoxide dismutase (Mn-SOD) and copper zinc-superoxide dismutase (CuZn-SOD) in rat's brain via constructing motion models of aerobic exercise, anaerobic exercise as well as aerobic and anaerobic alternative treadmill exercise training. Method: Aerobic exercise group was constructed by progressive load exercise, anaerobic exercise group treated with high-speed interval training, alternative exercise group treated with aerobic exercise and anaerobic exercise alternatively(24 rats in each group, training for 6 weeks). Meanwhile, normal control group was established(8 rats). After every 2 weeks training 8 rats were sacrificed in each group. Activities of T-SOD, Mn-SOD and CuZn-SOD in rat's brain were measured. Result: Content of T-SOD in rat's brain in anaerobic exercise group was less than that in normal control group after training two weeks (P<0.05). However, with extension of training periods, the level of T-SOD increased gradually (P<0.05). After two weeks training activities of T-SOD and Mn-SOD in rat's brain in alternative training group were the highest(P<0.05), then it decreased following extension of training periods. There was no significant difference of activities of CuZn-SOD in rat's brain among exercise groups and normal control group (P> 0.05). Conclusion: Anaerobic exercise for a certain period can increase the activity of T-SOD in rat's brain. Alternative training for two weeks may be the best for increasing the activities of T-SOD and Mn-SOD in rat's brain. This experiment suggested that exercise would not markedly influence the activity of CuZn-SOD in rat's brain.


Gu Y.,Tianjin Medical University | Ban X.,Armed Police Medical College | Xu S.,Armed Police Medical College | Cui Y.,Armed Police Medical College | And 2 more authors.
Chinese Journal of Clinical Oncology | Year: 2010

Objective: To investigate the effect of the L-selectin, integrin αL and integrin β2 expressions on the multiple-organ metastasis of breast cancer of TA2 mice. Methods: The pathologic character of spontaneous breast cancer with multiple-organ metastasis (high metastasis, Group A) and without distant metastasis (low metastasis, Group B) were observed by macroscopy and H&E staining sections. The level of the L-selectin, integrin αL and integrin β2 expressions in Group A, Group B and the metastatic tumors of Group A were detected using the immunohistochemical method. The level of the mRNA of L-selectin, integrin αL and integrin β2 relative expressions in the prmary tumors of Group A and Group B were detected by Real-time PCR method. Results: Hemorrhage and necrosis were visibly seen in all the primary tumors of the Group A which were poorly differentiated or undifferentiated. Pulmonary, hepatic and splenic metastases, and angiogenetic mimicry were observed in these tumors. The average positive cell percentage of integrin αL and L-selectin in primary tumors of Group A and Group B were 24.81% vs. 10.47% and 39.81% vs. 16.75%, respectively. The expressions of the proteins were significantly higher in Group A than in Group B (Z=-2.31, -2.14, respectively; P<0.05), while there was no significant difference in the expression of integrin β2 between the two groups. In Group A, the average levels of L-selectin expression were 39.81%, 39.07%, 62.09% and 55.51% in the primary tumors, and the pulmonary, hepatic and splenic metastatic tumors, respectively, among which the average expression of L-selectin was significantly higher in liver metastatic tumor than in primary tumor (Z=-2.24, P=0.025), while there was no markedly difference in the expression of integrin αL and integrin β2 between the primary and metastastic tumor. The levels of L-selectin and integrin αL mRNA relative expression were significantly higher in the primary tumros of Group A than in those of Group B (Z=-3.32, -3.47; P<0.01). Conclusion: L-selectin, integrin αL and integrin β2 could be expressed by spontaneous breast cancer cells of TA2 mice and the expression of L-selectin might be related to liver metastasis.


Mu H.,Armed Police Medical College | Shen C.,Armed Police Medical College | Zou Z.,Armed Police Medical College | Zheng A.,Armed Police Medical College | Liang K.,Armed Police Medical College
Chinese Journal of Clinical Oncology | Year: 2011

Objective: To evaluate the antitumor efficacy and impact of concomitant treatment with Gefitinib combined with Gamma Stereotactic Radiosurgery (SRS) and whole-brain radiotherapy (WBRT) in patients with brain metastases from NSCLC. Methods: Twenty-three NSCLC patients with brain metastases were reviewed retrospectively. All of them were treated with concomitant treatment of gefitinib, SRS and WBRT. The efficacy, toxicity, and survival were investigated. Results: In terms of intracranial lesions, the objective response rate (ORR) and the disease control rate (DCR) were 78.3% (18/23) and 91.3% (21/23), respectively. As for systemic disease, ORR and DCR were 21.7% (5/23) and 73.9% (17/23), respectively. The median time to disease progression (TDP) was 8.3 months, whereas the median overall survival (OS) time was 12.8 months. Univariate analysis showed that the KPS score, tumor volume, histological type, and RPA class were predictive factors for TDP (P = 0.000, 0.038, 0.048, and 0.000). The KPS score, tumor volume, and RPA class were predictive factors for OS of the patients (P = 0.000, 0.002, 0.004). The most common toxicities were rash and diarrhea, but all were well-tolerated. Conclusion: The current experimental data suggested that gefitinib concomitant with SRS and WBRT was very effective and safe for patients with brain metastases from NSCLC. The patients with better KPS score, RPA class, smaller tumor volume, and adenocarcinoma may have better survival rates.

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