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Ge H.-X.,Peking University | Wang Y.-J.,Peking University | Ning L.-H.,Armed Police Corps Hospital of Shanxi Province | Zhao Q.-Y.,Changping Hospital of Integrated Chinese and Western Medicine | And 2 more authors.
Journal of Medical Imaging and Health Informatics | Year: 2015

Objective: The study was to investigate the risk factors for coagulopathy and countermeasures during cefoperazone sodium and sulbactam sodium (CPZ-SBT) injection, which could provide scientific reference for the safety of clinical rational drug use. Methods: In our study, 79 patients that have been diagnosed with pneumonia were treated with CPZ-SBT and retrospectively investigated for duration of one year. Records of these patients were reviewed for age, sex, underlying disease, albumin, alanine transaminase, total bilirubin, prothrombin time (PT), nutritional approach, prognosis, hospitalization duration, additional antibiotics and hemorrhage. Results: PT prolongation occurred in 30 out of 79 patients (38.0%). The rate of PT prolongation was significantly higher in the patients with total parenteral nutrition than enteral nutrition (62% vs. 38%, P = 0.009). It was more common in patients receiving antibiotics combinations than single CPZ-SBT (44.3% vs. 16.7%, P = 0.034). In addition, synergistic effect appeared in patients with total parenteral nutrition and combined with antibiotics (P = 0.003). Positive stool occult test and positive gastric juice occult test were significantly different (25.3% vs. 12.1%, P = 0.001; 29.1% vs. 8.9%, P = 0.002, respectively). PT was prolonged for 6.6 ± 3.6 days after initiation of CPZ-SBT injection, and rapidly returned to normal in all patients treated with vitamin K1 after 1.4 ± 0.9 days. Conclusion: PT prolongation was susceptible to parenteral nutrition and share antibiotics for the patients treated with CPZ-SBT. The coagulopathy could be reversed by an intramuscular injection of 10 mg/d vitamin K1. We recommend daily intramuscular injection vitamin K1 for these patients. Copyright © 2015 American Scientific Publishers All rights reserved.

Han X.,456th Hospital of Jinan Military Command | Yang S.,Armed Police Corps Hospital of Shanxi Province | Zheng J.,The General Hospital
International Journal of Clinical and Experimental Pathology | Year: 2014

This study aimed to explore the clinicopathological characteristics and differential diagnosis of primary neuroendocrine tumor (G1) of the testis. In this paper, we analyze the clinical, histomorphological and immunohistochemical findings, treatment and prognosis of a patient with primary neuroendocrine tumor of the testis, and discuss the relevant literature. A 52-year-old man presented with a painless testicular swelling since 6 months. Histopathological examination showed that the tumor cells were arranged in island and beam patterns. The tumor cells were uniform, polygonal and had moderately eosinophilic cytoplasm and fine granular nuclear chromatin. Immunohistochemical staining showed that the tumor cells were positive for cytokeratin, CD56, synaptophysin and chromogranin A, and negative for inhibin, placental alkaline phosphatase and alpha-fetoprotein. Primary neuroendocrine tumor of the testis is a rare tumor with characteristic imaging features. Its accurate diagnosis depends on the morphological and immunohistochemical findings. These tumors should be differentiated from metastatic neuroendocrine carcinomas, teratomas with carcinoid, seminomas, Sertoli cell tumors and granulosa cell tumors. The treatment of most primary neuroendocrine tumors involves surgical resection combined with other therapies and usually results in a good prognosis.

An R.,PLA Fourth Military Medical University | Zhao L.,PLA Fourth Military Medical University | Xi C.,Baoji City Peoples Hospital | Li H.,PLA Fourth Military Medical University | And 4 more authors.
Basic research in cardiology | Year: 2016

Myocardial dysfunction is an important manifestation of sepsis. Previous studies suggest that melatonin is protective against sepsis. In addition, activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway has been reported to be beneficial in sepsis. However, the role of PI3K/Akt signaling in the protective effect of melatonin against sepsis-induced myocardial dysfunction remains unclear. Here, LY294002, a PI3K inhibitor, was used to investigate the role of PI3K/Akt signaling in mediating the effects of melatonin on sepsis-induced myocardial injury. Cecal ligation and puncture (CLP) surgery was used to establish a rat model of sepsis. Melatonin was administrated to rats intraperitoneally (30 mg/kg). The survival rate, measures of myocardial injury and cardiac performance, serum lactate dehydrogenase level, inflammatory cytokine levels, oxidative stress level, and the extent of myocardial apoptosis were assessed. The results suggest that melatonin administration after CLP surgery improved survival rates and cardiac function, attenuated myocardial injury and apoptosis, and decreased the serum lactate dehydrogenase level. Melatonin decreased the production of the inflammatory cytokines TNF-α, IL-1β, and HMGB1, increased anti-oxidant enzyme activity, and decreased the expression of markers of oxidative damage. Levels of phosphorylated Akt (p-Akt), unphosphorylated Akt (Akt), Bcl-2, and Bax were measured by Western blot. Melatonin increased p-Akt levels, which suggests Akt pathway activation. Melatonin induced higher Bcl-2 expression and lower Bax expression, suggesting inhibition of apoptosis. All protective effects of melatonin were abolished by LY294002, the PI3K inhibitor. In conclusion, our results demonstrate that melatonin mitigates myocardial injury in sepsis via PI3K/Akt signaling activation.

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