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Yang S.,Armed Police Corps Hospital of Shanxi Province | Zheng J.,The General Hospital
International Journal of Clinical and Experimental Pathology

This study aimed to explore the clinicopathological characteristics and differential diagnosis of primary neuroendocrine tumor (G1) of the testis. In this paper, we analyze the clinical, histomorphological and immunohistochemical findings, treatment and prognosis of a patient with primary neuroendocrine tumor of the testis, and discuss the relevant literature. A 52-year-old man presented with a painless testicular swelling since 6 months. Histopathological examination showed that the tumor cells were arranged in island and beam patterns. The tumor cells were uniform, polygonal and had moderately eosinophilic cytoplasm and fine granular nuclear chromatin. Immunohistochemical staining showed that the tumor cells were positive for cytokeratin, CD56, synaptophysin and chromogranin A, and negative for inhibin, placental alkaline phosphatase and alpha-fetoprotein. Primary neuroendocrine tumor of the testis is a rare tumor with characteristic imaging features. Its accurate diagnosis depends on the morphological and immunohistochemical findings. These tumors should be differentiated from metastatic neuroendocrine carcinomas, teratomas with carcinoid, seminomas, Sertoli cell tumors and granulosa cell tumors. The treatment of most primary neuroendocrine tumors involves surgical resection combined with other therapies and usually results in a good prognosis. Source

Ge H.-X.,Peking University | Wang Y.-J.,Peking University | Ning L.-H.,Armed Police Corps Hospital of Shanxi Province | Zhao Q.-Y.,Changping Hospital of Integrated Chinese and Western Medicine | And 2 more authors.
Journal of Medical Imaging and Health Informatics

Objective: The study was to investigate the risk factors for coagulopathy and countermeasures during cefoperazone sodium and sulbactam sodium (CPZ-SBT) injection, which could provide scientific reference for the safety of clinical rational drug use. Methods: In our study, 79 patients that have been diagnosed with pneumonia were treated with CPZ-SBT and retrospectively investigated for duration of one year. Records of these patients were reviewed for age, sex, underlying disease, albumin, alanine transaminase, total bilirubin, prothrombin time (PT), nutritional approach, prognosis, hospitalization duration, additional antibiotics and hemorrhage. Results: PT prolongation occurred in 30 out of 79 patients (38.0%). The rate of PT prolongation was significantly higher in the patients with total parenteral nutrition than enteral nutrition (62% vs. 38%, P = 0.009). It was more common in patients receiving antibiotics combinations than single CPZ-SBT (44.3% vs. 16.7%, P = 0.034). In addition, synergistic effect appeared in patients with total parenteral nutrition and combined with antibiotics (P = 0.003). Positive stool occult test and positive gastric juice occult test were significantly different (25.3% vs. 12.1%, P = 0.001; 29.1% vs. 8.9%, P = 0.002, respectively). PT was prolonged for 6.6 ± 3.6 days after initiation of CPZ-SBT injection, and rapidly returned to normal in all patients treated with vitamin K1 after 1.4 ± 0.9 days. Conclusion: PT prolongation was susceptible to parenteral nutrition and share antibiotics for the patients treated with CPZ-SBT. The coagulopathy could be reversed by an intramuscular injection of 10 mg/d vitamin K1. We recommend daily intramuscular injection vitamin K1 for these patients. Copyright © 2015 American Scientific Publishers All rights reserved. Source

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