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Dashottar S.,Armed Forces Medical College AFMC | Singh A.K.,Army Hospital R and RDelhi | Suhag V.,Army Hospital R and RDelhi | Sunita,Base Hospital | Singh R.,Anaesthesia
Journal of Cardiovascular Disease Research | Year: 2015

Pulmonary artery aneurysm is rare condition in neonates which usually presents with compression on the surrounding vital structures. By definition, an aneurysm is focal dilatation of a blood vessel that involves all three layers of vessel wall. Pulmonary artery aneurysm is defined as focal or fusiform dilatation of the PA beyond its maximum normal caliber. Early recognition and treatment are important for reducing morbidity and preventing mortality. The patients of PAA can be absolutely asymptomatic clinically and may be detected on radiograph or computed tomography or echocardiography. They may present as chest pain, dysnoea, or hemoptysis. It requires multidisciplinary approach for the diagnosis and treatment. It is very important to diagnose and manage the PAA as early as possible due to its high morbidity and mortality. Hence CTA is most important for the accurate evaluation of the PAA for its prompt diagnosis and treatment to reduce the risk of morbidity and mortality. Management of the PAA is surgical as well as medical depending upon the risk factors. The conservative management of PAA is serial follow up and periodic assessment of PAA. This is first case report of congenital aneurysm of pulmonary artery causing extrinsic compression over the left main bronchus leading to collapse. The case was successfully managed with surgical translocation of RPA in front of Ascending aorta, angioplasty of MPA & LPA and repair of the ASD; thereby relieving the compression over the left main bronchus and future complications. Source


Behera C.,All India Institute of Medical Sciences | Rautji R.,Armed Forces Medical College AFMC | Sikary A.K.,All India Institute of Medical Sciences | Kumar R.,All India Institute of Medical Sciences | And 3 more authors.
Medicine, Science and the Law | Year: 2015

Filicide-suicide is a special category of homicide-suicide event where the victim(s) are children and the perpetrator is one of the parents or both. It is not extensively documented or adequately defined in literature. In developed countries, shooting is a common method of homicide and suicide. Uses of knives, blunt objects, strangulation, poisoning and drowning are other methods frequently employed by the perpetrator. Homicide by hanging in filicide-suicide is rarely reported in forensic literature. We present a rare case of filicide-suicide, where the mother killed both her children by hanging them one by one from a ceiling fan in the same room and later committed suicide by hanging in another room. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. Source


Dey M.,Armed Forces Medical College AFMC | Sharma S.,All India Institute of Medical Sciences | Aggarwal S.,All India Institute of Medical Sciences
North American Journal of Medical Sciences | Year: 2013

Aneuploidies are a major cause of perinatal morbidity and mortality. Therefore, it is the most common indication for invasive prenatal diagnosis. Initially, screening for aneuploidies started with maternal age risk estimation. Later on, serum testing for biochemical markers and ultrasound markers were added. Women detected to be at high-risk for aneuploidies were offered invasive testing. New research is now focusing on non-invasive prenatal testing using cell-free fetal DNA in maternal circulation. The advantage of this technique is the ability to reduce the risk of miscarriage associated with invasive diagnostic procedures. However, this new technique has its own set of technical limitations and ethical issues at present and careful consideration is required before broad implementation. Source


Rangan N.M.,Military Dental Center | Sahoo N.K.,Armed Forces Medical College AFMC | Tomar K.,NIDS | Chattopadhyay P.K.,ADC R and R
Journal of Oral and Maxillofacial Surgery | Year: 2014

Introduction: The patients with cranial deformity suffer from headache, dizziness, irritability, loss of concentration, depression, anxiety, intolerance to noise and vibration and neuromotor weakness. It is therefore essential to restore the calvarium. Material and Method: This study was conducted in the Department of Oral and Maxillofacial Surgery, Armed Forces Medical College, Pune between Oct 2010 and Mar 2012. The study population was selected from the outpatient department and from the referred cases. The aim was to study the uptake of split thickness calvarial graft in the management of residual cranial defect. After applying the inclusion and exclusion criterions, ten cases were selected with residual cranial deformity, operated for cranioplasty using split thickness calvarial graft and evaluated. Conclusion: It was concluded that cranioplasty using autogenous split thickness calvarial graft for restoring cranial defects is a useful technique and this procedure allows the surgeon to reconstruct a moderate-to-large cranial defect, without breaching the inner cortical plate. © The Association of Oral and Maxillofacial Surgeons of India 2015. Source


Saraswathy S.,Guru Gobind Singh Indraprastha University | Sahai K.,Armed Forces Medical College AFMC | Krishnan M.,Institute of Nuclear Medicine and Allied Sciences | Mendiratta S.L.,North DMC Medical College | And 2 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Objective: To quantify cell free fetal DNA (cffDNA) with fetal specific epigenetic marker, hypermethylated RASSF1A, in maternal plasma of normal pregnant women from 20 weeks of gestation and to assess its relationship with maternal age, height, pre-pregnancy weight and body mass index (BMI). Methods: Hundred normal pregnant women within the gestational age of 21–40 weeks were randomly selected and grouped into five (n = 20). Group 1: 21–24, Group 2: 25–28, Group 3: 29–32, Group 4: 33–36 and Group 5: 37–40 weeks. Maternal plasma DNA was extracted, digested with methylation-sensitive restriction enzyme, BstUI and the fetal specific DNA (cffDNA) was quantified by Real-time polymerase chain reaction (qRT-PCR). Results: The mean hypermethylated RASSF1A concentrations in different gestational groups were Group 1: 30.1 ± 14.9, Group 2: 52.6 ± 22.18, Group 3: 93.2 ± 19.08, Group 4: 172.8 ± 26.81 and Group 5: 337.8 ± 52.9 copies/ml. Pearson’s correlation analysis showed highly significant positive correlation between cffDNA and gestational age (r = 0.899, p < 0.001). BMI was also found to be positively related to cffDNA (r = 0.217, p < 0.05). However, it did not show any correlation with maternal age, height and pre-pregnancy weight. Conclusions: The gestational age-dependent increase of hypermethylated RASSF1A; the fetal specific epigenetic marker in maternal plasma was demonstrated, in an Indian study group of normal pregnant women. Findings would form the basis of future studies involving pregnancy complications that would aid in the early diagnosis of placental pathologies with hypermethylated RASSF1A. © 2016 Informa UK Limited, trading as Taylor & Francis Group. Source

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