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Seongnam, South Korea

Hwang Y.H.,Armed Forces Capital Hospital | Yoo C.,Korea University | Kim Y.Y.,Korea University
Journal of Glaucoma | Year: 2012

PURPOSE: The purpose of the study was to investigate the effects of myopic optic disc tilt and rotation on peripapillary retinal nerve fiber layer (RNFL) thickness characteristics measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). METHODS: A total of 93 right eyes from 93 healthy young male individuals with myopia underwent ophthalmic examinations, including refractive error, axial length, and optic disc area measurements. The superior/inferior peak locations, RNFL thickness, and horizontal/vertical optic disc tilt were evaluated using the Cirrus HD OCT. The optic disc rotation was assessed by the angle between the long axis of the optic disc and the vertical meridian. The patients were divided into the tilted group and the non-tilted group; the tilted group was further divided into the rotated group and the nonrotated group. RESULTS: The eyes in the tilted group (n=47) had a greater axial length and thicker temporal RNFL and more temporally positioned superior/inferior peak locations than the non-tilted group (n=46) (all P <0.05). Among the eyes in the tilted group, the eyes in the rotated group (n=23) had a thicker temporal RNFL and a more temporally positioned superior peak location than the eyes in the nonrotated group (n=24) (all P <0.05). CONCLUSIONS: The eyes with a myopic temporal optic disc tilt and counterclockwise rotation had a thicker temporal RNFL and more temporally positioned superior peak location. The characteristics of the RNFL thickness in eyes with myopic optic disc tilt and rotation should be considered when interpreting the RNFL thickness measured by the Cirrus HD OCT. Copyright © 2012 by Lippincott Williams & Wilkins.


Hwang Y.H.,Armed Forces Capital Hospital | Yoo C.,Korea University | Kim Y.Y.,Korea University
Journal of Glaucoma | Year: 2012

Purpose: To investigate the correlation between myopic optic disc tilt and the characteristics of peripapillary retinal nerve fiber layer (RNFL) thickness measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT; Carl Zeiss Meditec, Dublin, CA). Methods: A total of 255 eyes of 255 healthy young male participants with various degrees of refractive errors (mean spherical equivalent, -3.17±2.40 D; range, -11.00 to 0.00 D) underwent ophthalmic examinations, including refractive error, axial length, and optic disc area measurement. The degree of horizontal/vertical optic disc tilt was evaluated by cross-sectional images obtained by the Cirrus HD OCT. The average, superior, nasal, inferior, and temporal quadrant thickness and superior/inferior peak locations of the peripapillary RNFL were also measured with the Cirrus HD OCT. Results: On the univariate analysis, eyes with more temporally tilted optic discs (horizontal tilt) had higher myopia, greater axial length, a thinner average, superior, nasal, and inferior RNFL, thicker temporal RNFL, and more temporally positioned superior/inferior peak locations (all P values <0.001). The degree of inferior optic disc tilt (vertical tilt) was associated with high myopia and a more temporally positioned inferior peak location (all P values <0.05). On multivariate analysis, eyes with more temporally tilted optic discs had a thicker temporal RNFL and more temporally positioned superior/inferior peak locations. Conclusions: The characteristics of the peripapillary RNFL thickness were associated with the degree of myopic optic disc tilt, especially in the temporal area. The degree of myopic optic disc tilt should be considered when interpreting the RNFL thickness measured by the Cirrus HD OCT. © 2012 by Lippincott Williams & Wilkins.


Chung D.R.,Sungkyunkwan University | Huh K.,Armed Forces Capital Hospital
Expert Review of Anti-Infective Therapy | Year: 2015

Postinfluenza bacterial pneumonia is a leading cause of influenza-associated death, and Staphylococcus aureus and Streptococcus pneumoniae have been important pathogens that have caused pneumonia since the influenza pandemic in 1919. Emergence of novel influenza A (H1N1) pdm09 and the concomitant global spread of community-associated methicillin-resistant S. aureus (CA-MRSA) have led to increasing prevalence of CA-MRSA pneumonia following influenza infection. Such an epidemiologic change poses a therapeutic challenge due to a high risk of inappropriate empiric antimicrobial therapy and poor clinical outcomes. Early diagnosis and initiation of appropriate antimicrobial therapy for post-influenza bacterial pneumonia have become even more important in the era of CA-MRSA. Therefore, novel molecular diagnostic techniques should be applied to more readily diagnose MRSA pneumonia. © 2015 Informa UK, Ltd.


Cho Y.,Armed Forces Capital Hospital
Clinics in orthopedic surgery | Year: 2011

The purpose of this study is to evaluate the disease-free survival (DFS) and overall survival (OS) of patients with stage IIB osteosarcoma at a single institution for 20 years and to compare the results according to the chemotherapy protocols. From Jan 1988 to Nov 2008, 167 patients with osteosarcoma were treated at our hospital and among them, 117 patients (67 males and 50 females) with stage IIB osteosarcoma were evaluable. Their mean age was 22.6 years (range, 8 months to 71 years). Seventy-eight cases underwent the modified T10 (M-T10) protocol (group 1), 23 cases underwent the T20 protocol (group 2) and 16 cases underwent the T12 protocol (group 3). The DFS and OS were calculated and compared according to the chemotherapy protocols. At a mean follow-up of 78.9 months, 63 patients were continuously disease-free (63/117), 6 patients were alive after having metastatic lesions, 7 patients died of other cause and 41 patients died of their disease. The 5- and 10-year OS rates were 60.2% and 44.8%, respectively and the 5- and 10-year DFS rates were 53.5% and 41.4%, respectively. There was no significant difference of the OS and DFS between the chemotherapy protocols (p = 0.692, p = 0.113). At present, we achieved success rates close to the internationally accepted DFS and OS. We were able to achieve the higher survival rates using the M-T10 protocol over the 20 years. However, there was no significant difference of results between the chemotherapy protocols. We think the M-T10 protocol will achieve more favorable results in the near future.


Hwang Y.H.,Armed Forces Capital Hospital | Lee J.Y.,Korea University | Kim Y.Y.,Korea University
British Journal of Ophthalmology | Year: 2011

Background/aims: To evaluate the effect of head tilt on retinal nerve fibre layer (RNFL) and macular thickness measured by the Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). Methods: A total of 30 right eyes from 30 healthy young subjects underwent RNFL and macular thickness measurements with the Cirrus HD OCT. The measurements were performed at a baseline head position and at right and left head tilt positions. The differences in RNFL and macular thickness between the baseline head position and the positions with head tilt were analysed. Results: The right and left head tilt induced counter-clockwise (mean 8.27°) and clockwise (mean 8.47°) rotation of the optic disc. The right head tilt caused superior-temporal RNFL thickening, inferior-temporal RNFL thinning, superior outer macular thickening and inferior outer macular thinning (all p values <0.05). The left head tilt induced superior-temporal RNFL thinning, inferior-temporal RNFL thickening, superior outer macular thinning, nasal outer macular thickening and inferior outer macular thickening (all p values <0.05). Conclusions: RNFL and macular thickness measured with the Cirrus HD OCT was affected by head tilt. Artefacts caused by head tilt should be considered in the analysis of the Cirrus HD OCT measurements.

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