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Le Touquet – Paris-Plage, France

Nevoux J.,University Paris - Sud | Nevoux J.,French Institute of Health and Medical Research | Loundon N.,University Paris - Sud | Loundon N.,French Institute of Health and Medical Research | And 7 more authors.
International Journal of Pediatric Otorhinolaryngology

Background: Numerous complications have been described following cochlear implantation. Most of them are post-operative and benign, but some are intra-operative and can be more difficult to manage. Methods: Case report of a pediatric case of misplaced cochlear electrode in the carotid canal and literature review. Results and conclusions: Post-operative CT-scan allowed the diagnosis. The misplaced cochlear implant in the carotid canal was successfully removed and a successful re-implantation followed immediately. Anatomy of the interval between the cochlea and the carotid canal is reviewed, together with information regarding the neural telemetry response.In each case, specific anatomical landmarks must be identified to perform the cochleostomy in the right position. If not, or if surgery proves itself difficult, the surgeon should intra-operatively control the position of the electrode. © 2010 Elsevier Ireland Ltd. Source

Visez N.,CNRS Atmospheric and Combustion Chemistry Laboratory | Chassard G.,CNRS Atmospheric and Combustion Chemistry Laboratory | Azarkan N.,CNRS Atmospheric and Combustion Chemistry Laboratory | Naas O.,Ziane Achour University of Djelfa | And 5 more authors.
Journal of Aerosol Science

Mechanical rupture of pollen grains after a mechanical shock against a solid surface was tested as a new approach to one of the mechanisms related to the release of allergen loaded particles from pollen. Birch pollen was aerosolized and sent into an impactor to mimic a shock against a surface (trees, soil, walls, etc.) at wind speeds of atmospheric-relevance. Small particles in the range of 1-2.5. μm were released subsequently to pollen impaction. The number of particles released increased with the velocity of impaction and with the water content of pollen. Damaged grains were observed by transmission electron microscopy and released particles are most likely cytoplasmic granules. This mechanism of pollen rupture and/or discharge may be of great importance in urban environment and may significantly contribute to thunderstorm-related allergic asthma and other associated pollen subparticles IgE mediated diseases. © 2015 Elsevier Ltd. Source

Harterink E.,Armand Trousseau Children Hospital | Harterink E.,University Utrecht | Leboulanger N.,Armand Trousseau Children Hospital | Kotti S.,Unite de Recherche Clinique de LEst Parisien | And 2 more authors.
Otology and Neurotology

OBJECTIVES: To assess the anatomic and functional outcome of underlay cartilage myringoplasty in children with cleft palate, at different postoperative periods compared with a patients-matched control group STUDY DESIGN: Case control study, tertiary referral center. METHODS: An otologic database was used to select children with cleft palate and perforated tympanic membrane who underwent myringoplasty between 1995 and 2012. These subjects were matched with control patients, without cleft palate, using the following criteria: age, size of perforation, status of contralateral ear, and status of middle ear mucosa. Charts were reviewed for the following: patients characteristics, preoperative findings, surgical data, postoperative anatomic and functional outcomes, and reinterventions. The postoperative findings were divided into 5 different periods. RESULTS: A group of 32 cleft palate patients as well as 32 control patients were included in this study, with a mean follow up of 63.6 ± 41 months. There were no differences between the groups in anatomic success as it was achieved in 84% in both groups. No differences were seen in functional outcome when compared with each different postoperative period. Using the last available audiogram, the postoperative mean air conduction and the air-bone gap were significantly worse in the cleft group compared with the control group, respectively, 26.1 ± 13.7 dB versus 18.4 ± 10.1 dB, p = 0.042; and 16.5 ± 9.4 dB and 11.3 ± 6.4 dB, p = 0.046. Additionally, the functional success was significantly worse in the cleft group; 58% versus 87% in the control group (OR, 5.5 [95% CI, 1.22-24.81], p = 0.027). CONCLUSION: Children with cleft palate can benefit from cartilage underlay myringoplasty in terms of closure of tympanic membrane, although there is a worse functional outcome. Copyright © 2014 Otology & Neurotology, Inc. Source

Brazdova A.,Armand Trousseau Children Hospital | Senechal H.,Armand Trousseau Children Hospital | Peltre G.,Armand Trousseau Children Hospital | Zidkova J.,Institute of Chemical Technology Prague | And 5 more authors.
Jordan Journal of Biological Sciences

Active immune mechanism in the female reproductive tract may produce high levels of anti-seminal/sperm antibodies. Generated antibodies in the process of isoimmunization seem to be associated with female immune infertility. The aim of our study consists in the profiling of specific serum immunoglobulin classes and subclasses in infertile women. We focus on the distribution of serum seminal/sperm-specific antibodies in order to find those apparently related to female isoimmunization. Immunoglobulins G1-4, A1,2, M and E were measured by ELISA in serum from 30 infertile and 10 fertile females. Anti-seminal/sperm IgG1 and IgG4 fractions were predominantly detected. Anti-seminal IgG1 and IgG4 were observed approximately in the 2:1 ratio, anti-sperm fraction in the 1:2 ratio. Strikingly, the approximate ratio between IgG1 and IgG2 was 3:1 in seminal specific and 2:1 in sperm specific antibodies. Surprisingly, IgG3 antibodies were nearly negative for both antigen fractions, seminal and sperm. Concerning our results, the proportionality does exist between seminal and sperm antibody fractions. Based on the poorly detectable levels of semen specific IgE, M, A1,2, G3, the markers of pathologic female isoimmunization appear to be the serum IgG1 and IgG4. These preliminary findings may contribute to a detailed patient diagnosis and an improved therapy. Source

Denoyelle F.,Armand Trousseau Children Hospital | Denoyelle F.,French Institute of Health and Medical Research | Leboulanger N.,Armand Trousseau Children Hospital | Leboulanger N.,French Institute of Health and Medical Research | And 9 more authors.
Otology and Neurotology

OBJECTIVE: To report preliminary results of a new closed-skin, transcutaneous bone conduction device (BCD) in 6 children with high-grade ear atresia SETTINGS: Tertiary care center; prospective study; we evaluated the gain with masking of the contralateral ear and the benefit of hearing rehabilitation with the transcutaneous BCD in noise: speech-in-noise tests, conducted in real life condition (with contralateral ear unmasked and fitted with a hearing device if done before implantation), with and without BCD, with determination of the speech reception threshold (SRT). Children and parent's satisfaction was assessed. RESULTS: Patients' ages ranged from 6 to 9 years. All had high-grade ear atresia with a preoperative mean pure-tone average (PTA) loss of 71.46 ± 6.59 dB on air conduction and 14 ± 4.98 dB on bone conduction. At M6, all children used the implant 5 to 12 hours daily (mean, 10) without pain or cutaneous complications. At M6, the mean air conduction PTA with transcutaneous BCD was 28.45 ± 1.68 dB, the mean gain 43 ± 6.96 dB, and the mean SRT gain 33.33 ± 10.75 dB. Using speech-in-noise tests in real-life conditions, the mean SRT was statistically improved with the transcutaneous BCD (-8 ± 2.83 dB, p = 0.0313). Both children and parents reported being satisfied or very satisfied. CONCLUSION: These preliminary results show satisfactory functional gain, cutaneous tolerance, and patients' satisfaction with the new transcutaneous BCD. Copyright © 2013 Otology & Neurotology, Inc. Source

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