arj University

Saudi Arabia

arj University

Saudi Arabia
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Attia M.,HLT consultant for The Engineering Company | Attia M.,Luxor Technologies Inc. | Almazyad A.,arj University | Almazyad A.,King Saud University | And 3 more authors.
IAENG International Journal of Computer Science | Year: 2011

This paper discusses the positive impact of soft vector quantization on the performance ofmachine-learning systems that include one or more vector quantization modules. The most impactful gains here are avoiding over-fitting and boosting the robustness of such systems in the presence of considerable parasitic variance; e.g. noise, in the runtime inputs.The paper then introduces a soft vector quantization scheme with inverse power-function distributions, and analytically derives an upper bound of its relative quantization noise energy to that of typical (hard-deciding) vector quantization. This relative noise is expressed as a closed-form function of the power in order to allow the selection of its optimal values of that compromise both a soft enough vector quantization with a stable performance via small enough relative quantization noise.Finally, we present empirical evidence obtained via experimenting with two versions of the best reported OCR system for cursive scripts - that happened to deploy discrete HMMs - one version with hard vector quantization and the other with our herein presented soft quantization. Test samples of real-life scanned Arabic text pages are used to challenge both versions; hence the recognition error margins are compared.

Ouban A.,Saba University | Ouban A.,arj University | Hamdan H.,Truman Medical Center | Hakam A.,H. Lee Moffitt Cancer Center and Research Institute | Ahmed A.A.,Childrens Mercy Hospitals and Clinics
International Journal of Surgical Pathology | Year: 2012

Claudins are the main sealing proteins of the intercellular tight junctions and play an important role in cancer cell progression and dissemination. This study examined and compared the expression of claudin-1 by immunohistochemistry in 60 squamous cell carcinomas of different tissue types and normal 33 controls, arranged in 2 tissue microarray slides. A score was generated to classify claudin-1 expression into negative, low, medium, and high. Most squamous cell carcinomas (91.67%) showed positive membranous staining. Medium to high claudin-1 expression was prevalent in carcinomas from the head-neck, skin, and genitourinary regions and was less frequent in other locations. An inverse correlation was noted between claudin-1 expression and tumor grade in tumors of the genitourinary and breast-gynecologic regions. Of the normal organs, significant claudin-1 expression was present mainly in the skin whereas other epithelial tissues had only minimal to low expression levels. Claudin-1 expression in squamous cell carcinoma varies in organ-specific manner reflecting influence of local factors and different mechanisms of claudin-1 expression. Knowledge of this fact is important in planning biologic therapy targeting claudin-1. © 2012 The Author(s).

Alafeefy A.M.,arj University | El-Azab A.S.,King Saud University | Mohamed M.A.,arj University | Bakhat M.A.,arj University | Abdel-Hamid S.G.,arj University
Journal of Saudi Chemical Society | Year: 2011

A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c]quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported. © 2011 King Saud University.

PubMed | arj University
Type: Evaluation Studies | Journal: Journal of enzyme inhibition and medicinal chemistry | Year: 2012

Twenty-two quinazoline derivatives have been synthesised and examined for their anti-tumour activity against three tumour cell lines, namely human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human hepatoma cell line (HepG2). Twelve of the tested compounds have shown promising anti-tumour activity with an IC(50) range of 5.0-9.7 g/mL. Regarding the spectrum of activity, five compounds exhibited interesting anti-proliferative properties against the three tested cell lines comparable to the reference drug (dasatinib).

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