Aristotle University of Thessaloniki
Thessaloniki, Greece

The Aristotle University of Thessaloniki is among the oldest and most prestigious higher education institutions of Greece. It is the largest university in Greece and in the Balkans. It is named after the philosopher Aristotle, who was born in Stageira, about 55 km east of Thessaloniki. Its campus covers 230,000 square metres in the centre of Thessaloniki, with additional educational and administrative facilities elsewhere.More than 95,000 students study at the Aristotle University, 86,000 in undergraduate programmes and 9,000 in postgraduate programmes. The Teaching and Research Staff number 2,248 people , the Scientific Teaching Staff number 84 and the Special Laboratory Teaching Staff 275 people. They are supported by 309 members of the Special Technical Laboratory for teaching services and the 1028 administrative staff.The language of instruction is Greek, although there are programs in foreign languages and courses for international students, which are carried out in English, French, German, and Italian. Wikipedia.

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Aristotle University of Thessaloniki and PAVLIDIS & Partners Co. | Date: 2017-02-01

Method for snail extract acquisition, more particularly of Cornu aspersum, comprising at least two steps, being remarkable in that a first step for obtaining the extract consists of a non stressful snail extract acquisition, wherein a batch of snails is selected which are brought to move by crawling on a set of surface means, particularly glass plates, under a set of predetermined conditions including moisture, temperature and duration, yielding a quantity of clear pedal mucus, which is removed from said surface means and placed into receptacles. It is followed by a further step consisting of drying with a subsequent resuspension step of the produced snail extract, resp. of a centrifugation of said snail extract.

Bikiaris D.N.,Aristotle University of Thessaloniki
Expert Opinion on Drug Delivery | Year: 2011

Introduction: The absorption of poorly water-soluble drugs, when presented in the crystalline state to the gastrointestinal tract, is typically dissolution rate-limited, and according to BCS these drugs belong mainly to class II. Both dissolution kinetics and solubility are particle size dependent. Nowadays, various techniques are available to the pharmaceutical industry for dissolution rate enhancement of such drugs. Among such techniques, nanosuspensions and drug formulation in solid dispersions are those with the highest interest. Areas covered: This review discusses strategies undertaken over the last 10 years, which have been applied for the dissolution enhancement of poorly water-soluble drugs; such processes include melt mixing, electrospinning, microwave irradiation and the use of inorganic nanoparticles. Expert opinion: Many problems in this field still need to be solved, mainly the use of toxic solvents, and for this reason the use of innovative new procedures and materials will increase over the coming years. Melt mixing remains extremely promising for the preparation of SDs and will probably become the most used method in the future for the preparation of solid drug dispersions. © 2011 Informa UK, Ltd.

Flaskos J.,Aristotle University of Thessaloniki
Toxicology Letters | Year: 2012

Several extensively used organophosphorus ester (OP) insecticides are phosphorothionates. The oxon metabolites of phosphorothionates have long been known to be responsible for the acute cholinergic neurotoxicity associated with OP poisoning. In addition, there is now sufficient evidence to suggest that the oxon metabolites may also be directly responsible for the particular neurotoxicity that phosphorothionate insecticides, and especially chlorpyrifos (CP) and diazinon (DZ), are known to inflict on the developing organism. In vitro data reveal that the oxons, which are present at increased levels in the developing brain, have the ability to directly disrupt, at toxicologically relevant doses, separately a number of neurodevelopmental processes, including those of neuronal proliferation, neuronal differentiation, gliogenesis and apoptosis. In most cases, the effects of the oxons are very potent. Inhibition of neuronal and glial cell differentiation by the oxons in particular is up to 1000-times stronger than that caused by their parent phosphorothionates. The neurodevelopmental toxicity of the oxons is not related to the inhibition of the enzymatic activity of acetylcholinesterase (AChE), but may be due to direct oxon interference with the morphogenic activity that AChE normally shows during neurodevelopment. Other possible direct targets of the oxons include neurodevelopmentally important cell signaling molecules and cytoskeletal proteins which have been found to be affected by the oxons and to which covalent binding of the oxons has been recently shown. Future studies should aim at confirming the developmental neurotoxic capacity of the oxons under in vivo conditions and they must also be extended to include OP parent insecticides with a P. O moiety. © 2011 Elsevier Ireland Ltd.

Introduction: In recent years, the number of active pharmaceutical ingredients with high therapeutic impact, but very low water solubility, has increased significantly. Thus, a great challenge for pharmaceutical technology is to create new formulations and efficient drug-delivery systems to overcome these dissolution problems. Areas covered: Drug formulation in solid dispersions (SDs) is one of the most commonly used techniques for the dissolution rate enhancement of poorly water-soluble drugs. Generally, SDs can be defined as a dispersion of active ingredients in molecular, amorphous and/or microcrystalline forms into an inert carrier. This review covers literature which states that the dissolution enhancement of SDs is based on the fact that drugs in the nanoscale range, or in amorphous phase, dissolve faster and to a greater extent than micronized drug particles. This is in accordance to the NoyesWhitney equation, while the wetting properties of the used polymer may also play an important role. Expert opinion: The main factors why SD-based pharmaceutical products on the market are steadily increasing over the last few years are: the recent progress in various methods used for the preparation of SDs, the effect of evolved interactions in physical state of the drug and formulation stability during storage, the characterization of the physical state of the drug and the mechanism of dissolution rate enhancement. © 2011 Informa UK, Ltd.

Papa A.,Aristotle University of Thessaloniki
Antiviral Research | Year: 2012

Dobrava-Belgrade virus (DOBV) is an Old World hantavirus that causes hemorrhagic fever with renal syndrome in humans. With a case fatality rate up to 12%, DOBV infection is the most life-threatening hantavirus disease in Europe. The virus was initially identified in the Balkans, but the discovery of new endemic foci have expanded its recognized geographic range. The recent description of novel genetic variants with different degrees of pathogenicity have complicated its taxonomic analysis. The original rodent host of DOBV is Apodemus flavicollis, however additional Apodemus species, such Apodemus agrarius and Apodemus ponticus, have been found to serve as hosts of the various DOBV genotypes. The complex evolution and genetic diversity of the virus are still under investigation. The present review aims to provide an update on the phylogeny of DOBV and the epidemiology of infection in rodents and humans; to describe the clinical characteristics of the disease; to present current knowledge about laboratory diagnosis, treatment and prevention; discuss the current state of the art in antiviral drug and vaccine development. © 2012 Elsevier B.V..

Geronikaki A.,Aristotle University of Thessaloniki
Current topics in medicinal chemistry | Year: 2013

The last two decades are characterized by major increases in the incidence of systemic fungal infections caused by the yeast Candida albicans, particularly in immunocompromised patients. On the other hand it was observed the increased number of pathogenic microorganisms with multiple resistance to drugs. Also there is a big variety of drugs for the treatment of candidiasis, only two drugs are used for the treatment of infections from Aspergillus fumigatus. Taking into account that the long term therapy with azoles results in resistance a critical need exists for new antifungal agents with fewer side effecgts to treat these life-threatening fungal infections. This review will cover the advances in research of biological activity of different compounds from different chemical classes with focus on their antifungal properties.

Hatzimouratidis K.,Aristotle University of Thessaloniki
European urology | Year: 2010

Erectile dysfunction (ED) and premature ejaculation (PE) are the two most prevalent male sexual dysfunctions. To present the updated version of 2009 European Association of Urology (EAU) guidelines on ED and PE. A systematic review of the recent literature on the epidemiology, diagnosis, and treatment of ED and PE was performed. Levels of evidence and grades of recommendation were assigned. ED is highly prevalent, and 5-20% of men have moderate to severe ED. ED shares common risk factors with cardiovascular disease. Diagnosis is based on medical and sexual history, including validated questionnaires. Physical examination and laboratory testing must be tailored to the patient's complaints and risk factors. Treatment is based on phosphodiesterase type 5 inhibitors (PDE5-Is), including sildenafil, tadalafil, and vardenafil. PDE5-Is have high efficacy and safety rates, even in difficult-to-treat populations such as patients with diabetes mellitus. Treatment options for patients who do not respond to PDE5-Is or for whom PDE5-Is are contraindicated include intracavernous injections, intraurethral alprostadil, vacuum constriction devices, or implantation of a penile prosthesis. PE has prevalence rates of 20-30%. PE may be classified as lifelong (primary) or acquired (secondary). Diagnosis is based on medical and sexual history assessing intravaginal ejaculatory latency time, perceived control, distress, and interpersonal difficulty related to the ejaculatory dysfunction. Physical examination and laboratory testing may be needed in selected patients only. Pharmacotherapy is the basis of treatment in lifelong PE, including daily dosing of selective serotonin reuptake inhibitors and topical anaesthetics. Dapoxetine is the only drug approved for the on-demand treatment of PE in Europe. Behavioural techniques may be efficacious as a monotherapy or in combination with pharmacotherapy. Recurrence is likely to occur after treatment withdrawal. These EAU guidelines summarise the present information on ED and PE. The extended version of the guidelines is available at the EAU Web site ( Copyright © 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Topouzis F.,Aristotle University of Thessaloniki
American journal of ophthalmology | Year: 2013

To investigate the association of open-angle glaucoma (OAG), primary open-angle glaucoma (POAG), and pseudoexfoliative glaucoma (PEXG) with ocular perfusion pressure status (ocular perfusion pressure with or without antihypertensive treatment). Cross-sectional, population-based study. A total of 2554 randomly selected, ≥ 60-year old subjects participated in the Thessaloniki Eye Study. Only clinic-visit participants (n = 2261), who had uniformly collected data, were included in the analyses. A logistic regression model was run for OAG in all clinic-visit participants; covariates included age, sex, diastolic ocular perfusion pressure, antihypertensive treatment, intraocular pressure (IOP), IOP-lowering treatment, pseudoexfoliation, and vascular factors identified as risk factors for glaucoma in a previous analysis. Similar logistic regression models were run separately for POAG and PEXG. In addition, logistic regression models were run for OAG, POAG, and PEXG in subjects with and without antihypertensive treatment. Also, logistic regression models were run to assess the role of systolic ocular perfusion pressure in OAG, POAG, and PEXG. Among clinic-visits, 1212 subjects (53.7%) were using antihypertensive treatment. An association of borderline significance was found between low diastolic ocular perfusion pressure and POAG (OR = 0.84 per 10 mm Hg, 95% CI = 0.70-1.01, P = .059). The effect of antihypertensive treatment on POAG was not statistically significant (OR = 1.20, 95% CI = 0.75-1.91, P = .45). In subgroup analyses, diastolic ocular perfusion pressure was significantly associated with POAG in subjects using antihypertensive treatment (OR = 0.78 per 10 mm Hg, 95% CI = 0.62-0.97, P = .028). No association was found between diastolic ocular perfusion pressure and PEXG, regardless of the use of antihypertensive treatment. No associations were found between systolic ocular perfusion pressure and OAG, POAG, or PEXG, regardless of the use of antihypertensive treatment. Low diastolic ocular perfusion pressure may be associated with increased risk for POAG. This association was confirmed in subjects treated for systemic hypertension in subgroup analysis. This may support the hypothesis that the concept of ocular perfusion pressure status may be more relevant to glaucoma pathogenesis than ocular perfusion pressure alone. Copyright © 2013 Elsevier Inc. All rights reserved.

The invention concerns an ultra-sensitive and accurate electrical impedance spectroscopy technique for the detection and characterization of bubbles in liquids that is required in numerous industrial processes as well as in the humans blood circulation during Decompression Sickness. The method is based on measuring non-invasively the electrical impedance variation of two-phase mixtures: liquid as conductive phase, resp. gas as non-conductive phase, applying an AC excitation signal of the proper frequency value identified by preliminary frequency scanning. The system takes advantage of innovative signal acquisition (hardware) device, and digital signal processing (software) methods and manages to detect accurately for the first time even the presence of a few bubbles corresponding to extremely low volumetric gas fraction values, up to < 0,1%. Also, the high measurement sensitivity of 0,001% in conjunction with advanced signal processing provides valuable qualitative and quantitative information on bubble size characteristics and allows for correlating bubble size to the spectral content of acquired signals.

Aristotle University of Thessaloniki | Date: 2016-05-11

The present invention relates to anti-counterfeiting and authentication digital marking, including marking conveyed through multiple types of signatures, notably to a method for applying on metallic products different layers corresponding to different signature types. It also relates to a system capable of exciting automatically and with high security the data mark in order to retrieve, overlay and transmit a number of plural-bit messages with steganographic properties. A first type of signature corresponds to an optically captured image data which is only visible under a non-visible spectrum illumination; a second type also to an optically captured image data which is only visible under a different second non-visible spectrum illumination; and a third type to an optically captured image data of magneto-optical filter which is only detectable under a controlled variable magnetic excitation.

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