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San Jose, CA, United States

Patent
Ariosa Diagnostics, Inc. | Date: 2014-02-10

This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.


Patent
Ariosa Diagnostics, Inc. | Date: 2015-12-07

The present invention provides multiplexed sequential ligation-based analysis of genetic variants in a mixed sample, including copy number variations and single nucleotide polymorphisms. The invention employs the techniques of sequential ligation and amplification.


The present invention provides methods for determining the fraction of fetal DNA in a maternal sample using massively parallel shotgun sequencing techniques and statistical probability calculations. The invention utilizes a novel method of identifying polymorphisms through the sequencing process that align to designated regions in the genome. By identifying a statistically significant number of such polymorphisms in multiple designated regions across the genome the fetal fraction, or estimation thereof, can be determined. In certain aspects, the observed distribution of polymorphisms in the genome of a maternal sample can be compared to a fetal proportion reference to estimate the fetal fraction in the sample.


Patent
Ariosa Diagnostics, Inc. | Date: 2015-09-14

The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.


Patent
Ariosa Diagnostics, Inc. | Date: 2014-02-10

This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.

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