Matsuoka K.,Area for Molecular Function |
Yamaguchi H.,Area for Molecular Function |
Koyama T.,Area for Molecular Function |
Hatano K.,Area for Molecular Function |
Terunuma D.,Area for Molecular Function
Tetrahedron Letters | Year: 2010
Synthetic construction of fucosyl chitobiose [GlcNAcβ1→4(Fucα1→3)GlcNAc] as an allergy-associated carbohydrate epitope was accomplished from three building blocks. The trisaccharidic unit was further transformed into a carbohydrate monomer and polymerization of the glycomonomer proceeded smoothly to provide a series of glycopolymers having various carbohydrate densities. In addition to the organic syntheses, biological evaluations of the glycomonomer and the polymers were carried out and sugar-clustering effects were observed. © 2010 Elsevier Ltd. All rights reserved.