Han F.,are Pharmaceutical Randnter |
Lin S.,are Pharmaceutical Randnter |
Liu P.,are Pharmaceutical Randnter |
Tao J.,are Pharmaceutical Randnter |
And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014
Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway by PI3K/mTOR dual inhibitors provides a promising new approach to the treatment of cancers. In this Letter, we identified structurally novel and potent PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives. Their synthesis and structure-activity relationships are reported. © 2014 Elsevier Ltd. All rights reserved.